Further Observations on the Mechanism by Which Androgens and Growth Hormone Influence Erythropoiesis*

Meineke, Howard A.; Crafts, Roger C.

doi:10.1111/j.1749-6632.1968.tb15165.x

Cited by 31 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rapid increase in plasma EPO suggests a direct stimulating action of GH on EPO secretion. GH stimulated erythropoiesis in nephrectomized and hypophysectomized rats (25) and in rat bone marrow perfused with GH (26). Furthermore, GH directly stimulated the proliferation of erythroid progenitor cells in vitro (12).…”

Section: Discussionmentioning

confidence: 99%

Stimulation of erythropoietin secretion by continuous subcutaneous infusion of recombinant human GH in anemic patients with chronic renal failure

Sohmiya

Ishikawa

Kato

1998

European Journal of Endocrinology

View full text Add to dashboard Cite

We have investigated the effect of human GH on erythropoietin (EPO) secretion in eight anemic patients with chronic renal failure (CRF) (three males and ®ve females, aged from 46 to 83 years). Recombinant human GH was infused subcutaneously at a¯ow rate of 2 mg/kg body weight per 0.1 ml/h for 72 h using a portable infusion pump. Blood samples were obtained immediately before and 2, 4,6,12,24,36, 48, 60, 72, 84, 96, 108, 120 and 168 h after the start of GH infusion. Storage urine samples were obtained before and 24, 48 and 72 h after the start of the infusion. The mean (6 S.E.M.) basal plasma GH levels increased from 1.9 6 0.3 to 18.8 6 0.7 mg/l during the GH infusion. Plasma IGF-I levels increased 12 h after the start of GH treatment and the mean peak values of 403.6 6 38.5 mg/l were obtained at 72 h. Plasma EPO levels increased 6 h after the start of GH infusion, and the peak values of 38.4 6 11.6 IU/l were obtained at 96 h (P < 0.05 vs basal values 24.5 6 7.2 IU/l). Reticulocyte counts increased from 28.7 6 5.2´10 3 /ml to 40.3 6 8.0´10 3 /ml at 108 h, 43.6 6 9.2´10 3 /ml at 120 h and 41.7 6 7.7´10 3 /ml at 160 h (P < 0.05). Serum urea nitrogen decreased at 72 h (P < 0.05), whereas there was no signi®cant change in urinary excretion of nitrogen. Hemoglobin levels were not signi®cantly changed throughout the experimental period. These ®ndings indicate that human GH has a stimulating effect on EPO secretion in anemic patients with CRF.

show abstract

Section: Discussionmentioning

confidence: 99%

Stimulation of erythropoietin secretion by continuous subcutaneous infusion of recombinant human GH in anemic patients with chronic renal failure

Sohmiya

Ishikawa

Kato

1998

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Androgen and thyroid hormones are known to stimulate erythropoiesis (Alexanian 1969). Growth hormone (GH) has a stimulatory effect on erythropoiesis (Fisher et al 1964, Meineke & Crafts 1968, Peschle et al 1972, Golde et al 1977. GH directly stimulated the proliferation of erythroid progenitor cells in vitro (Golde et al 1977).…”

Section: Introductionmentioning

confidence: 99%

“…GH directly stimulated the proliferation of erythroid progenitor cells in vitro (Golde et al 1977). Erythropoiesis was stimulated in rat bone marrow perfused with GH (Meineke & Crafts 1968) and in nephrectomized and hypophysectomized rats (Fisher et al 1964) in vivo. Hypoplastic bone marrow was restored by GH treatment, but not by adrenocorticotropic hormone, follicle stimulating hormone, luteinizing hormone, or thyroid-stimulating hormone (Jepson & Lowenstein 1964, Nagy & Berczi 1989.…”

Section: Introductionmentioning

confidence: 99%

Human growth hormone and insulin-like growth factor-I inhibit erythropoietin secretion from the kidneys of adult rats

Sohmiya

Kato²

2005

Journal of Endocrinology

View full text Add to dashboard Cite

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) play important roles in erythropoiesis and erythropoietin (EPO) secretion. We examined the effects of GH and IGF-I on EPO production in adult rat kidney and liver in vivo and in vitro. Male Wistar rats aged 8-10 weeks were used. Recombinant human GH (hGH) was continuously infused (20 µg/kg per h) subcutaneously for 48 h using a micro-osmotic infusion pump. Octreotide (10 µg/kg) was subcutaneously injected every 12 h beginning 12 h before the hGH treatment. GH increased plasma EPO levels earlier than it increased plasma IGF-I levels. At 24 h, the IGF-I content in the liver and kidney was increased from 172·8 14·6 to 232·6 17·8 ng/g tissue (means S.E.) and from 53·8 3·1 to 112·8 7·2 ng/g tissue, respectively. The EPO content in the liver was increased from 7·5 1·2 to 15·1 1·4 mIU/g tissue at 48 h, whereas the EPO content in the kidney was decreased at 12, 24, and 48 h after the start of hGH treatment. When the kidneys were organ-cultured, hGH considerably decreased EPO levels in the culture medium in a dose-related manner. The addition of anti-hGH IgG blunted the GH-induced inhibition of EPO secretion from the kidneys. IGF-I also decreased EPO levels in the medium in a dose-related manner. The addition of anti-IGF-I IgG blunted the IGF-I-induced inhibition of EPO secretion from the kidneys, whereas the GH-induced inhibition of EPO secretion was not affected. These findings suggest that both hGH and IGF-I have direct inhibitory effects on EPO secretion from adult rat kidneys.

show abstract

“…Studies employing nephrectomized adult animals have shown that this effect is dependent on the presence of kidneys (24). However, the efficacy of androgens in promoting extrarenal Ep with confirmed dates of conception were obtained from local suppliers, observed, acclimated for at least 5 d, and then fasted for 24 h before surgery.…”

Section: Introductionmentioning

confidence: 99%

“…The effect of L-T4 and DT on erytlhropoiesis in these fetuses was also monitored by admiiinistering 50 tCi[59Fe]Cl3 to each fetus via the intravenouis catheter 24 h after the last injection of the hormone. The radioiron was preincubated with 2 ml of the fetus's plasma for 30 min at 37°C before injection.…”

Section: Introductionmentioning

confidence: 99%

Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Zanjani¹,

Banisadre²

1979

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T The effect of testosterone (DT) and thyroxin (L-T4) on erythropoiesis and erythropoietin (Ep) These data demonstrate that (a) DT aind L-T4 are effective promnoters of extrarenal Ep production, thereby enhancing erythropoiesis in intact and nephrectomized fetuses; (b) DT is a stronger stimulus of extrarenal Ep formation than L-T4; and (c) Ep is required for the expression of the erythropoietic effects of L-T4 and DT.

show abstract

Further Observations on the Mechanism by Which Androgens and Growth Hormone Influence Erythropoiesis*

Cited by 31 publications

References 10 publications

Stimulation of erythropoietin secretion by continuous subcutaneous infusion of recombinant human GH in anemic patients with chronic renal failure

Stimulation of erythropoietin secretion by continuous subcutaneous infusion of recombinant human GH in anemic patients with chronic renal failure

Human growth hormone and insulin-like growth factor-I inhibit erythropoietin secretion from the kidneys of adult rats

Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Contact Info

Product

Resources

About