Further observations on the nature of the house dust antigen

Cohen, Milton B.; Cohen, Stanley; Hawver, Kenneth

doi:10.1016/s0021-8707(39)90250-9

Cited by 14 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Spain, JIMINEZ-DIAZ et al [11] demonstrated in 1928 that ''house dust'' sensitivity was often due to moulds. COHEN et al [12] showed that cotton and kapok-stuffed mattresses, pillows and furniture were potent sources of ''house dust antigen'', and that removal of the offending articles abolished asthmatic symptoms in those in whom mould allergy was demonstrated. Cases of asthma attributed to Alternaria, Aspergillus fumigatus and Trichophyton spp.…”

Section: Early Descriptionsmentioning

confidence: 99%

The link between fungi and severe asthma: a summary of the evidence

Denning

O’Driscoll²,

Hogaboam³

et al. 2006

Eur Respir J

731

631

View full text Add to dashboard Cite

There is current evidence to demonstrate a close association between fungal sensitisation and asthma severity. Whether such an association is causal remains to be confirmed, but this is explored by means of a detailed literature review. There is evidence from two randomised controlled trials that, in the example of allergic bronchopulmonary aspergillosis (ABPA), treatment with systemic antifungal therapy can offer a therapeutic benefit to ,60% of patients. ABPA is only diagnosed if a combination of clinical and immunological criteria is achieved. It is not known whether such cases are a discrete clinical entity or part of a spectrum of the pulmonary allergic response to fungi or fungal products.This paper describes the epidemiological evidence that associates severity of asthma with fungi and discusses possible pathogenetic mechanisms. Many airborne fungi are involved, including species of Alternaria, Aspergillus, Cladosporium and Penicillium, and exposure may be indoors, outdoors or both. The potential for a therapeutic role of antifungal agents for patients with severe asthma and fungal sensitisation is also explored.Not only are many patients with severe asthma desperately disabled by their disease, but, in the UK alone, asthma accounts for 1,500 deaths per yr. The healthcare costs of these patients are enormous and any treatment option merits close scrutiny. Within this report, the case for the consideration of a new term related to this association is put forward. The current authors propose the term ''severe asthma with fungal sensitisation''. However, it is recognised that enhanced and precise definition of fungal sensitisation will require improvements in diagnostic testing.

show abstract

Section: Early Descriptionsmentioning

confidence: 99%

The link between fungi and severe asthma: a summary of the evidence

Denning

O’Driscoll²,

Hogaboam³

et al. 2006

Eur Respir J

731

631

View full text Add to dashboard Cite

show abstract

“…While modern literature struggles to find examples of asthma prevention or improvement in asthma symptoms occurring due to allergen avoidance, there were abundant early reports of asthma control improving due to removal of mouldy housing materials, such as mattresses, pillows and furniture [4].…”

Section: Severe Asthma and Fungal Sensitizationmentioning

confidence: 99%

Asthma and mould allergy – Does it matter?

Niven

2006

Medical Mycology

View full text Add to dashboard Cite

“…Placental transmission of antibodies responsible for anaphylactic shock has been demonstrated in the lower animals by Rosenau and Anderson (5), Otto (6), Wells (7), Schenck (8), Lewis (9), Ratner and his coworkers (10), and Cohen and Woodruff (11). Cohen, Cohen, and Hawver (12) reported the presence of skin-sensitlzing antibodies in the blood of a newborn rhesus monkey after injection of a sensitive human serum into the mother within 7 days prior to delivery.…”

mentioning

confidence: 98%

The Placental Transmission of Antibodies in the Skin Sensitive Type of Human Allergy

Sherman

Hampton

Cooke

1940

Journal of Experimental Medicine

View full text Add to dashboard Cite

It has been suggested that the transmission of skin-sensitizing antibodies from the maternal to the fetal circulation may be a factor in the development of allergic diseases. Certain other antibodies such as diphtheria antitoxin, typhoid agglutinin, tetanus antitoxin, hemolysins, and bacteriolysins, have been shown to pass through the human placenta from mother to fetus. Excellent reviews of this subject have been published by Ratner, Jackson, and Gruehl (1), Bell and Erickkson (2), Lippard and Wheeler (3), and Wiener and Silverman (4) and others. Placental transmission of antibodies responsible for anaphylactic shock has been demonstrated in the lower animals by Rosenau and Anderson (5), Otto (6), Wells (7), Schenck (8), Lewis (9), Ratner and his coworkers (10), and Cohen and Woodruff (11). Cohen, Cohen, and Hawver (12) reported the presence of skin-sensitlzing antibodies in the blood of a newborn rhesus monkey after injection of a sensitive human serum into the mother within 7 days prior to delivery.Placental transmission of skin-sensitizing antibodies in the human being has not been shown. Bell and Erickkson (2) were unable to demonstrate in the cord sera of 10 allergic mothers the skin-sensitizing antibodies that were shown to be present in the maternal sera in various dilutions. Caulfeild (13) also reported inability to demonstrate skin-sensitizing antibodies in the cord sera of 2 allergic mothers. Walzer (14) in a discussion of Bell's paper supported Bell's findings. Zohn (15) was unable to show such antibodies in the cord blood of 11 women actively sensitized and skin-reactive to Ascaris lumbricoides, although the maternal blood of 9 of the women was positive by passive transfer tests.Wiener and Silverman (4), on the basis of titratiorr of the hemagglutinin content of maternal and cord blood, reported that "the index of permeability of the human placenta to antibodies or the coefficient of distribution of antibodies between maternal and cord blood" falls between 8 and 16. They suggested that the failure to detect placental transmission of skin-sensitizing antibody was due to the small amounts present in the maternal blood and lack of quantitative studies thereof.Although all the direct evidence has shown there is no transmission of skin-sensitizing antibodies through the human placenta, the apparently contradictory evidence of transmission of other human antibodies and of certain anaphylactic antibodies in experimental animals has caused many to doubt that the point was completely proved. Therefore, it seems worth 611

show abstract

Further observations on the nature of the house dust antigen

Cited by 14 publications

References 6 publications

The link between fungi and severe asthma: a summary of the evidence

The link between fungi and severe asthma: a summary of the evidence

Asthma and mould allergy – Does it matter?

The Placental Transmission of Antibodies in the Skin Sensitive Type of Human Allergy

Contact Info

Product

Resources

About