Further observations on the primary paranasal aspergillus granuloma in the Sudan: A morphological study of 46 cases *

Veress, B; Malik, Osman A.; Tayeb, Ahmed A. El; Daoud, Sayed El; Mahgoub, El Sheikh; Hassan, Amro B.

doi:10.4269/ajtmh.1973.22.765

Cited by 122 publications

(62 citation statements)

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“…Histopathological evaluation shows there is profuse fungal growth with regional tissue invasion, noncaseating granulomas with giant cells, and plasma cells. Unless removed surgically, the resulting fibrous fungal mass may spread into the orbit, dura, and brain [13]. Treatment with itraconazole at a dose of 8 to 10 mg per kilogram per day appears to decrease the otherwise high postoperative relapse rate [14].…”

Section: Classification Of Invasive Fungal Sinusitismentioning

confidence: 99%

Syndromes of invasive fungal sinusitis

deShazo

2009

Med Mycol

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Invasive fungal sinusitis should be suspected in immunocompromised or diabetic patients who present with acute sinusitis, inflammation of nasal septal mucosa, unexplained fever or cough, or the orbital apex syndrome. Histopathological studies are required to differentiate among these syndromes. Acute (fulminant) invasive fungal sinusitis has been called mucormycosis, zygomycosis and fulminant invasive sinusitis. Fever, cough, crusting of nasal mucosa, epistaxis, and headache are the most common presenting symptoms. Histopathological studies show hyphal invasion of blood vessels, vasculitis with thrombosis, and tissue infarction. Reports of granulomatous invasive fungal sinusitis come primarily from Sudan, but also from India, Pakistan, and the United States. Patients usually present with proptosis, appear to be immunocompetent and are infected almost exclusively with A. flavus. Chronic invasive fungal sinusitis can be distinguished from the two other forms of invasive fungal sinusitis by its chronic course, dense accumulation of hyphae resembling a mycetoma, and association with the orbital apex syndrome, diabetes mellitus, and corticosteroid treatment. Biopsy and orbital exploration show vascular invasion by fungal elements and only a sparse chronic inflammatory infiltrate.

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Section: Classification Of Invasive Fungal Sinusitismentioning

confidence: 99%

Syndromes of invasive fungal sinusitis

deShazo

2009

Med Mycol

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“…Central microgranulomata of eosinophils, fibrinoid necrosis, fibrosis, and vasculitis have also been noted. 45 Unless removed surgically, the resulting fibrous fungal mass may spread into the orbit, dura, and brain. Treatment with itraconazole at a dose of 8 to 10 mg per kilogram per day appears to decrease the high postoperative relapse rate.…”

Section: Granulomatous Invasive Fungal Sinusitismentioning

confidence: 99%

Fungal Sinusitis

deShazo¹,

1997

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“…18 Since then, this condition was reported mainly from the Sudan but also from other tropical areas, including the Indian subcontinent. 10,[19][20][21][22][23] Therapy for chronic invasive Aspergillus sinusitis includes surgical evacuation and antifungal chemotherapy. Nevertheless, outcome is poor and the disease frequently relapses.…”

Section: Introductionmentioning

confidence: 99%

Chronic invasive aspergillosis of the paranasal sinuses in immunocompetent hosts from Saudi Arabia.

Alrajhi¹,

Enani²,

Mahasin³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. In immunocompetent patients, paranasal invasive aspergillosis is rare and has a high recurrence rate. Twenty-three cases of paranasal invasive aspergillosis, involving 14 male and nine female immunocompetent patients were reviewed. All patients were cancer-free, HIV-negative, with normal WBC, and none of the patients had received immunosuppressive therapy or corticosteroids. Mean duration of symptoms before diagnosis was 18 months. Aspergillus flavus was the species most frequently isolated. Surgical debridement was performed in all patients followed by antifungal therapy in 18 patients. Mean follow-up duration was 30 months. Fourteen patients relapsed after a mean of 13 months and required an average of 4.3 admissions for repeat surgical evacuation. In a logistic regression model, relapse was not associated with age, duration of symptoms, clinical findings, extent of disease, or mode of therapy. However, patients who were relapse-free tended to have had complete surgical evacuation followed by antifungal therapy.

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Further observations on the primary paranasal aspergillus granuloma in the Sudan: A morphological study of 46 cases *

Cited by 122 publications

References 0 publications

Syndromes of invasive fungal sinusitis

Syndromes of invasive fungal sinusitis

Fungal Sinusitis

Chronic invasive aspergillosis of the paranasal sinuses in immunocompetent hosts from Saudi Arabia.

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