Further Observations on the Use of the Saturation Method of Radiation Therapy in Deep-Seated Malignant Disease, with Some Statistics

Pfahler, George E.; Widmann, Bernard P.

doi:10.1148/11.3.181

Cited by 4 publications

(1 citation statement)

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“…Excessive normal tissue damage caused by these single-dose treatments caused many radiotherapists to revert back to the fractionation technique, although sometimes bearing little resemblance to earlier fractionation schemes. For example, the Pfahler-Kingery technique employed in the 1920's (Kingery 1920;Pfahler and Widman 1928) used a large initial dose to start treatment but completed it with gradually diminishing daily doses over the next 2-3 wk. The most important and careful study of fractionation at that time was that of Claude Regault and Henri Coutard in Paris (Coutard Fig. 14.…”

Section: Fractionationmentioning

confidence: 99%

Uses of Therapeutic X-Rays in Medicine

Orton¹

1995

Health Physics

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Treatment of diseases with x rays began within months of Roentgen's discovery, and within four years x rays were being used successfully for the treatment of skin cancers. Deep-seated cancers began to be treated successfully in the 1920's with the advent of "deep" x-ray units and, especially, once supervoltage therapy machines became available in the 1930's. The 1940's and 1950's saw significant growth of megavoltage therapy, initially with Van de Graaff generators and betatrons, and later with linear accelerators. Linear accelerators became popular during the 1960's and 1970's and, by the 1980's they began to replace 60Co units as the most common form of treatment machine. With high-energy linear accelerators, computerized treatment planning, and ingenious fractionation schemes, modern radiotherapy has become a vital component of cancer treatment.

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Section: Fractionationmentioning

confidence: 99%

Uses of Therapeutic X-Rays in Medicine

Orton¹

1995

Health Physics

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Accelerated treatment

Thomas¹

1985

Cancer

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In the first third of this century, the prevailing concept was that malignant cells had a brief period of sensitivity and radiation treatments were ideally given in overall times of 2 weeks or less. Following the Second World War, routine treatment times were extended to 5 to 8 weeks to avoid severe acute normal tissue reactions and achieve higher tumor doses. In reaction to these prolonged overall times, a series of large-fraction, shortened-overall-time clinical experiments were attempted, with disastrous normal tissue effects and poor tumor control. More recently, attempts to accelerate treatment have been accomplished by utilizing multiple fractions per day or semicontinuous irradiation. Unfortunately, the majority of these attempts have been forced by the occurrence of unacceptable normal tissue reactions to significantly reduce total dose or introduce lengthy splits in treatment. These results suggest that in our current state of knowledge accelerated schedules be reserved for use in the treatment of rapidly proliferating neoplasms or for palliation.Cuncer 5 5 2 1 12-21 17. 1985.

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Bioeffect Dosimetry in Radiation Therapy

Orton

1986

Radiation Dosimetry

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Further Observations on the Use of the Saturation Method of Radiation Therapy in Deep-Seated Malignant Disease, with Some Statistics

Cited by 4 publications

References 0 publications

Uses of Therapeutic X-Rays in Medicine

Uses of Therapeutic X-Rays in Medicine

Accelerated treatment

Bioeffect Dosimetry in Radiation Therapy

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