Further Studies in Detection and Diagnosis of prostatic Carcinoma

Cline, Joseph K.; Burke, L. S.; Cobb, William R.; Wilkinson, Margaret Ann; Johnson, Robert B.

doi:10.1016/s0022-5347(17)67412-3

Cited by 20 publications

(4 citation statements)

References 7 publications

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“…Etwas häufiger als die kaum vorkommenden falsch-positiven sind die falsch-negativen Resultate. In letzter Zeit wurden Methoden angegeben zum Nachweis einer noch spezifischeren, sogenannten «prostatischen», sauren Phosphatase [10,6]. Ihre Bestimmung ist jedoch kompliziert, und die Resultate nur in einzelnen Fällen besser als bei dem viel einfacheren Nach weis der totalen sauren Phosphatase.…”

Section: Fa N D E N Kutscher U N D Wolbergsunclassified

Die hormonale Behandlung des Prostata-Carcinoms

Martz¹

1959

Oncology

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Section: Fa N D E N Kutscher U N D Wolbergsunclassified

Die hormonale Behandlung des Prostata-Carcinoms

Martz¹

1959

Oncology

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“…He also has shown that the heterologous growth of the transplanted lesion became resistant to estrogen and that it responded in the same way as prostatic cancer does in human beings. 14 The use of hormonal therapy, which first was suggested by the brilliant work of Huggins, Stevens and Hodges, 5 has revolutionized the treatment of advanced carcinoma of the prostate. Physicians are ail familiar with the miraculous improvement that results from use of this treatment in cases in which the patients are emaciated, pain-ridden and bedridden.…”

Section: Postcraduate Medicinementioning

confidence: 99%

Diagnosis and Treatment of Carcinoma of the Prostate

Alyea

Galleher

1956

Postgraduate Medicine

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“…Both the total and the tartrate-labile AcP in the serum may be increased in diseases other than carcinoma of the prostate (Sullivan et al, 1942;Herbert, 1946;Cooke et al, 1962) or by artefact (Bonner et al, 1954;Ozar et al, 1955). Marked elevation of either fraction is rarely found except in carcinoma of the prostate (Bensley et al, 1948;Cline et al, 1955) and has not previously been described in association with carcinoma of the bronchus. …”

mentioning

confidence: 99%

Acid phosphatase activity in carcinoma of the bronchus

Nicholls¹,

Davies²

1977

Thorax

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. (1977). Thorax, 32,[472][473][474][475][476][477]. Acid phosphatase activity in carcinoma of the bronchus. Two cases are presented in which an undifferentiated small-cell carcinoma of the bronchus was associated with a considerably raised serum tartrate-labile acid phosphatase concentration. In neither case was there any evidence of a carcinoma of the prostate which, with a few rare exceptions, is the only condition associated with such increased enzyme activity. A survey of acid phosphatase concentrations in 30 other male patients with carcinoma of the bronchus showed that five patients had a raised total acid phosphatase concentration, but only one patient had a raised tartrate-labile acid phosphatase concentration. When the histological type was taken into account, elevated total acid phosphatase concentrations were associated with squamous-cell and adenocarcinoma but not with undifferentiated, small-cell carcinoma. Raised tartrate-labile acid phosphatase concentrations were associated only with squamous-cell carcinoma, in contradistinction to the two individual cases reported. In no group was there any correlation between acid and alkaline phosphatase concentrations.Histological studies in one of our patients showed little tissue acid phosphatase staining in the primary tumours but intense staining in the cytoplasm of pancreatic cells surrounding a metastasis. Sections of pancreas from six normal subjects showed only slight tissue acid phosphatase activity. The possible sources of the increased serum acid phosphatase are discussed, and it is suggested that the pancreas could be the source of such increased activity in our second case.Acid phosphatase (AcP) activity in the serum is derived from several sources. The fraction arising from the prostate gland is usually isolated by tartrate-inhibition (Abul-Fadl and King, 1949), but the specificity of this has been questioned (Dow and Whitaker, 1970;Yam, 1974). Both the total and the tartrate-labile AcP in the serum may be increased in diseases other than carcinoma of the prostate (Sullivan et al., 1942;Herbert, 1946;Cooke et al., 1962) or by artefact (Bonner et al., 1954;Ozar et al., 1955). Marked elevation of either fraction is rarely found except in carcinoma of the prostate (Bensley et al., 1948;Cline et al., 1955) and has not previously been described in association with carcinoma of the bronchus.

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Further Studies in Detection and Diagnosis of prostatic Carcinoma

Cited by 20 publications

References 7 publications

Die hormonale Behandlung des Prostata-Carcinoms

Die hormonale Behandlung des Prostata-Carcinoms

Diagnosis and Treatment of Carcinoma of the Prostate

Acid phosphatase activity in carcinoma of the bronchus

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