Further studies of scratching during sleep

Savin, J.A.; Paterson, William E.; Oswald, Ian; Adám, K

doi:10.1111/j.1365-2133.1975.tb06495.x

Cited by 74 publications

(43 citation statements)

References 3 publications

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“…3,5 Several studies 8,9 have investigated the effect of scratching on sleep patterns of patients with AD. Patients with AD scratch more during sleep than do patients with other dermatologic disorders.…”

Section: Discussionmentioning

confidence: 99%

Sleep Fragmentation in Children With Atopic Dermatitis

Reuveni¹,

Chapnick²,

Tal³

et al. 1999

Arch Pediatr Adolesc Med

103

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To characterize the sleep pattern of children with atopic dermatitis in clinical remission.Methods: Fourteen children with atopic dermatitis, with a mean ± SD age of 6 ± 2 years, were recruited consecutively from a pediatric dermatology clinic. No participant had any other medical or psychiatric illness. The control group (n = 9, mean age 7 ± 1.8 years) was composed of children with mild "benign" snoring and no evidence of respiratory disturbance during sleep. All participating children were evaluated by formal all-night polysomnography, scratch electrodes, and self-reported questionnaires filled in by their parents.Results: The patients were studied when their skin condition was in remission. Sleep latency, total sleep time, and sleep efficiency were similar to the control group. The atopic dermatitis group had an average of 24.1 ± 8.1 events per hour of arousals and awakenings, compared with 15.4 ± 6.2 events per hour in the control group (PϽ.001). Direct observation, video monitoring, and scratch electrodes provided evidence of between 1 to 19 bouts of scratching per night, accounting for only 15% of the arousals and awakenings. The rest of the arousals and awakenings were not associated with any specific, identifiable polysomnographic event, such as apnea or jerks. Conclusion:Children with atopic dermatitis in clinical remission have sleep disturbances that are not related to scratching per se.

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Section: Discussionmentioning

confidence: 99%

Sleep Fragmentation in Children With Atopic Dermatitis

Reuveni¹,

Chapnick²,

Tal³

et al. 1999

Arch Pediatr Adolesc Med

103

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“…Scratch, the response evoked by itch, can be a spinal reflex in experimental animals (Sherrington, 1906). There is some evidence that scratch during sleep may also be a spinal reflex (Savin, Paterson, Oswald & Adam, 1975). If this is so, then scratch during sleep may not be influenced by the processes modulating the perception of itch.…”

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confidence: 99%

Naloxone modulates the perception of itch in man [letter]

Summerfield¹

1980

Brit J Clinical Pharma

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“…31 The standards of pruritus research have changed. The need to use objective methodology, which was raised by investigators in the field of pruritus years ago 32,33 and by hepatologists recently, 34 has been met. 35 In contrast to other symptoms, the sensation of pruritus invariably results in scratching behavior 36 ; accordingly, changes in this behavior as a result of an investigational intervention define the end points in clinical trials.…”

Section: Commentsmentioning

confidence: 99%

Treatment of the pruritus of cholestasis: From unbearable lightness to substance

Bergasa

2004

Hepatology

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Treatment of the Pruritus of Cholestasis: From Unbearable Lightness to SubstanceTerg R, Coronel E, Sorda J, Munoz AE, Findor J. Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study. J Hepatol 2002;37:717-722. (Reprinted with permission from Elsevier.) AbstractBackground & Aims: To assess the efficacy and safety of naltrexone for the short and long term treatment of pruritus of cholestasis. Methods: Twenty patients with pruritus and cholestasis were included. A baseline pruritus score was obtained over 1 week. Patients were then randomized to receive 50 mg/day of naltrexone or placebo for 2 weeks. Subsequently, a 1-week washout period ensued and patients were crossed over to the other therapy for 2 additional weeks. Pruritus was assessed daily with a visual analogue scale (VAS) from 0 to 10. Patients whose pruritus decreased >50% of basal with naltrexone received naltrexone 50 mg/day for 2 additional months. Results: Mean basal VAS was similar in both groups. VAS showed greater and more significant changes with naltrexone than with placebo (P < .0003). In nine out of 20 patients (45%) receiving naltrexone, pruritus decreased >50% compared to basal value, including five whose pruritus disappeared completely. No significant changes were observed in serum biochemistry. Most of the adverse events that occurred during the first 48 h of naltrexone therapy were consistent with opioid withdrawal-like phenomena and spontaneously disappeared 2 days after starting treatment. Conclusions: Naltrexone can be considered as an alternative option to treat pruritus of cholestasis. In the current study, side effects were transient and did not require specific medication.

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Further studies of scratching during sleep

Cited by 74 publications

References 3 publications

Sleep Fragmentation in Children With Atopic Dermatitis

Sleep Fragmentation in Children With Atopic Dermatitis

Naloxone modulates the perception of itch in man [letter]

Treatment of the pruritus of cholestasis: From unbearable lightness to substance

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