Further studies on carrageenan‐induced pleurisy in rats

Capasso, Francesco; Dunn, C. J.; Yamamoto, S; Willoughby, D. A.; Giroud, J. P.

doi:10.1002/path.1711160208

Cited by 96 publications

(32 citation statements)

References 12 publications

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“…É possível que, assim como a indometacina, componentes deste extrato estejam inibindo a biossíntese de prostaglandinas (Farsam et al, 2000). Na pleurisia, injeção intrapleural de carragenina promove aumento do volume do exsudato na cavidade pleural (Ammendola et al, 1975;Almeida et al, 1980) e migração leucocitária (Compasso et al, 1975;Almeida et al, 1980), o que constitui um método importante para avaliar infi ltrado infl amatório e confi rmar a atividade antiinfl amatória demonstrada através do edema de pata. Os antiinfl amatórios não-esteróides, tal como a indometacina, inibem a acumulação do exsudato e mobilização de leucócito entre 3 e 6 horas após carragenina (Vinegar et al, 1973;Almeida et al, 1980).…”

Section: Discussionunclassified

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Dutra¹,

Tavares²,

Ferraz³

et al. 2006

Rev. bras. farmacogn.

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RESUMO:O presente trabalho investigou as atividades analgésica e antiinfl amatória do extrato metanólico de rizomas de Echinodorus grandifl orus. Para isto, foram realizados os testes de contorções abdominais induzidas por ácido acético; tempo da lambida da pata induzida por formalina; edema de pata e pleurisia induzidas por carragenina. As doses de 100, 200 e 400 mg/kg inibiram as contorções em 34,30%, 35,84% e 36,07%, respectivamente. O tempo de lambida da primeira fase foi reduzido nas doses de 200 e 400 mg/kg, enquanto a segunda fase teve redução em 400 mg/kg. As doses testadas diminuíram o edema, enquanto o volume do exsudato foi reduzido em 24,61% na dose de 400 mg/kg. As doses de 200 e 400 mg/kg diminuíram a migração leucocitária. Os resultados indicam que o extrato de E. grandifl orus testado pode constituir alvo potencial para uso em terapias da dor e da infl amação. Unitermos:Echinodorus grandifl orus, atividade analgésica, atividade antiinfl amatória.ABSTRACT: "Investigation of analgesic and anti-infl ammatory activities of Echinodorus grandifl orus rhizomes methanol extract". The present work investigated the analgesic and antiinfl ammatory activities of the methanol extract of the rhizomes of Echinodorus grandifl orus. For this purpose, acetic acid writhing, paw licking induced by formalin, carrageenan-induced rat paw edema and pleurisy tests were performed. The doses of 100, 200 and 400 mg/kg inhibited the contortions 34.30%, 35.84% and 36.07%, respectively. The lick of the paw 1st phase was reduced at the doses of 200 and 400 mg/kg, while the 2nd phase had reduction at 400 mg/kg. All doses inhibited the paw edema, while the volume of the exsudate was reduced 24.61% in the dose of 400 mg/kg. The doses of 200 and 400 mg/kg decreased the leukocytes migration. The results indicate that the methanol extract of E. grandifl orus can constitute target potential for use in therapies of the pain and infl ammation.

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Section: Discussionunclassified

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Dutra¹,

Tavares²,

Ferraz³

et al. 2006

Rev. bras. farmacogn.

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“…13,14 Released from mast cells and platelets during injury or inflammation, 5-HT causes direct activation of sensory neurons via 5-HT type 3 (5-HT 3 ) receptor activation. Nociceptive impulses activating the sympathetic nervous system promote norepinephrine release, which in turn accelerates sensitization of the nociceptors, creating another vicious cycle .…”

Section: Transductionmentioning

confidence: 99%

Preemptive analgesia I: physiological pathways and pharmacological modalities

Kelly

Ahmad

Brull

2001

Can J Anesth/J Can Anesth

261

181

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P Pu ur rp po os se e: : This two-part review summarizes the current knowledge of physiological mechanisms, pharmacological modalities and controversial issues surrounding preemptive analgesia.S So ou ur rc ce e: : Articles from 1966 to present were obtained from the MEDLINE databases. Search terms included: analgesia, preemptive; neurotransmitters; pain, postoperative; hyperalgesia; sensitization, central nervous system; pathways, nociception; anesthetic techniques; analgesics, agents.P Pr ri in nc ci ip pa al l f fi in nd di in ng gs s: : The physiological basis of preemptive analgesia is complex and involves modification of the pain pathways. The pharmacological modalities available may modify the physiological responses at various levels. Effective preemptive analgesic techniques require multi-modal interception of nociceptive input, increasing threshold for nociception, and blocking or decreasing nociceptor receptor activation. Although the literature is controversial regarding the effectiveness of preemptive analgesia, some general recommendations can be helpful in guiding clinical care. Regional anesthesia induced prior to surgical trauma and continued well into the postoperative period is effective in attenuating peripheral and central sensitization. Pharmacologic agents such as NSAIDs (non-steroidal anti-inflammatory drugs) opioids, and NMDA (Nmethyl-D-aspartate) -and alpha-2-receptor antagonists, especially when used in combination, act synergistically to decrease postoperative pain.C Co on nc cl lu us si io on n: : The variable patient characteristics and timing of preemptive analgesia in relation to surgical noxious input requires individualization of the technique(s) chosen. Multi-modal analgesic techniques appear most effective.Objectif : La présente revue, en deux parties, résume les connaissances actuelles sur les mécanismes physiologiques et les modalités pharmacologiques de lanalgésie préventive ainsi que sur les questions controversées qui lentourent.Sources : Des articles, de 1966 à aujourdhui, obtenus à partir des bases de données MEDLINE. Les termes de la recherche compren-

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“…This test elicits an acute inflammatory response, characterized by the accumulation of fluid containing large number of leucocytes (Ammendola et al 1975, Almeida et al 1980, Capasso et al 1975. It is an interesting method that evaluates the leucocyte migration during the inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory

Del-Vechio-Vieira

Santos

Alves

et al. 2016

An. Acad. Bras. Ciênc.

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The present study was designed to investigate the antioxidant, antinociceptive and anti-inflammatory activities of the ethanol extract from Ageratum fastigiatum branches. Phytochemical screening and total phenol and flavonoid contents were determined. The antioxidant activity was assessed by 2,2-diphenyl-1-pycrilhydrazin (DPPH) and iron reducing power methods. The antinociceptive effect was evaluated using the acetic acid-induced writhing, formalin, hot plate and tail immersion assays; while the carrageenaninduced paw edema and pleurisy tests were performed to examine the anti-inflammatory activity against acute inflammation. The extract revealed the presence of flavonoids, tannins, coumarins, terpenes, sterols and saponins. Expressive levels of total phenols and flavonoids and a promising antioxidant effect were quantified. At the doses of 50, 100 and 200 mg/kg, the extract inhibited the writhing, reduced both phases of paw licking time and increased the reaction time on the hot plate. In the tail immersion test, the extract (50, 100 and 200 mg/kg) caused a significant inhibition of pain. In these doses, the paw edema, exudate volume and leucocyte mobilization were significantly reduced. These results suggest that A. fastigiatum can be an active source of substances with antioxidant, antinociceptive and anti-inflammatory activities, adding scientific support to the appropriate use in the Brazilian folk medicine.

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Further studies on carrageenan‐induced pleurisy in rats

Cited by 96 publications

References 12 publications

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Investigação das atividades analgésica e antiinflamatória do extrato metanólico dos rizomas de Echinodorus grandiflorus

Preemptive analgesia I: physiological pathways and pharmacological modalities

Bioactivities of the ethanol extract from Ageratum fastigiatum branches: antioxidant, antinociceptive and anti-inflammatory

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