Further Studies on the Luteotropic Action of Estrogen in Rats

Uchida, Keiji; Kadowaki, Masumi; Miyake, Tamotsu; Wakabayashi, Katsumi

doi:10.1507/endocrj1954.20.103

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…Uchida et al (12) also found a transient release of PRL for about 35 h after treatment with 10 /xg estradiol benzoate at oestrus but did not find high PRL levels during the early morning or late afternoon on the days studied {i.e. days 2-4), although an increased progesterone secretion for at least 6 days of treatment with estradiol benzoate was observed.…”

Section: Discussionmentioning

confidence: 85%

Serum Prolactin Concentrations during Hormonally Induced Pseudopregnancy in the Rat

Greef

Zeilmaker

1979

Endocrinology

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Treatment of 5-day cyclic rats with 10 or 100 microgram estradiol benzoate on the day of estrus induced a luteal phase in all animals studied. On the other hand, an injection with 1 microgram estradiol benzoate given on the same day failed to induce pseudopregnancy. When 10 mg progesterone were injected on the day of estrus, about 50% of the rats became pseudopregnant, whereas most of the remaining rats had a 6-day cycle. The injection of 10 or 100 microgram estradiol benzoate or 10 mg progesterone induced a period of increased PRL secretion which lasted for 2--4 days, followed by twice daily surges of PRL at the end of the dark and light periods, respectively. It is argued that pseudopregnancy induction by estradiol benzoate or progesterone is primarily a result of the induction of a period of increased PRL secretion. In this way, progesterone secretion by the recently formed corpora lutea is induced, and the elevated levels of progesterone in turn generate diurnal surges of PRL.

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Section: Discussionmentioning

confidence: 85%

Serum Prolactin Concentrations during Hormonally Induced Pseudopregnancy in the Rat

Greef

Zeilmaker

1979

Endocrinology

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“…As far as is known, this effect of the FF on the synthesis of progesterone has only been observed by YoungLai (1972), who noted that the conversion of pregnenolone to progesterone by equine granulosa cells in vitro was improved if the in¬ cubation medium contained FF rather than blood plasma from the same species. It is known that oestrogens can have a stimulatory effect on luteal function; they stimulate progesterone secretion by CL in vivo and increase their life-span in the rabbit (Keyes & Nalbandov, 1967;Johnson & Murray, 1974), rat (Takayama & Greenwald, 1973; Uchida, Kadowaki, Miyake & Wakabayashi, 1973;Abdi & Das, 1972) and hamster (Greenwald, 1973). Fuller & Hansel (1971) obtained a stimulation of progesterone synthesis by rabbit luteal cells in vitro, using 5 /ig oestradiol.…”

Section: Discussionmentioning

confidence: 99%

Effect of Follicular Fluid and Oestradiol on the Luteinization of Rat Granulosa Cells in Vitro

Bernard¹

1975

Reproduction

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“…Such a rhythm in the central nervous activity controlling PRL secretion has been observed in some experimental and natural conditions. In ovariectomized or cyclic rats a single injection of testosterone or estradiol can induce a daily rhythm of PRL secretion with high levels in the afternoon (Caligaris & Taleisnik 1983;Boehm et al 1986;Uchida et al 1973).…”

Section: Discussionmentioning

confidence: 99%

Estrous cycle lengthening by pentobarbital in the rat: prolactin involvement

Geiger¹,

Boehm²,

Aron³

1988

Acta Endocrinologica

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Abstract. Pentobarbital lengthens the estrous cycle when injected on diestrus 1 afternoon in the 4-day cyclic female rat. The present study was undertaken to elucidate the mechanisms involved. Bromocriptine (2.5 mg/kg sc) given 30 min before pentobarbital (30 mg/kg ip) prevented the effects of pentobarbital on both cycle lengthening and progesterone levels in diestrus 2. Serum prolactin concentrations rose 10 min after pentobarbital injection, peaked at 30 min, and returned to control values after 60 min. Our results suggest that pentobarbital-induced cycle lengthening is due to a high progesterone production on diestrus 2 morning related to the luteotropic action of prolactin.

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Further Studies on the Luteotropic Action of Estrogen in Rats

Cited by 10 publications

References 12 publications

Serum Prolactin Concentrations during Hormonally Induced Pseudopregnancy in the Rat

Serum Prolactin Concentrations during Hormonally Induced Pseudopregnancy in the Rat

Effect of Follicular Fluid and Oestradiol on the Luteinization of Rat Granulosa Cells in Vitro

Estrous cycle lengthening by pentobarbital in the rat: prolactin involvement

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