Further studies on the restoration of estrogen-induced sexual receptivity in ovariectomized mice treated with dihydrotestosterone: Effects of progesterone, dihydroprogesterone and LH-RH

Luttge, William G.; Sheets, Cindy S.

doi:10.1016/0091-3057(77)90255-6

Cited by 18 publications

(3 citation statements)

References 21 publications

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“…Pfaff [39] then demonstrated that, even after hypophysectomy, an injection of LHRH can enhance lordosis in a rat. Other studies confirm that LHRH can in crease sexual behaviors in females of other species includ ing laboratory mice, guinea pigs, ring doves, and Anole lizards [1,8,10,26].There are fewer reports that LHRH influences sexual be havior in males. LHRH reportedly reduces the latency of in tromission and ejaculation in both intact and testosteronetreated, castrated rats [36] The present study uses male rough-skinned newts, Tari cha granulosa, to investigate the role of LHRH in the mani festation of amphibian sexual behavior.…”

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confidence: 70%

Luteinizing Hormone-Releasing Hormone Involvement in the Reproductive Behavior of a Male Amphibian

et al. 1982

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The present study demonstrates that an intracerebroventricular injection of luteinizing hormone-releasing hormone (LHRH) activates sexual behaviors and elevates the plasma androgen concentrations in rough-skinned newts (Taricha granulosa). The stimulatory effect of LHRH on male behavior may be a seasonal phenomenon, because LHRH stimulation of sexual behavior was only observed during the early part of the breeding season (November and December). When an active LHRH antagonist was injected into male newts, sexual behavior was suppressed. These studies indicate that endogenous LHRH is involved in regulating sexual behavior in this amphibian.

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confidence: 70%

Luteinizing Hormone-Releasing Hormone Involvement in the Reproductive Behavior of a Male Amphibian

et al. 1982

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“…The ability of LHRH to influence sexual behaviour has been reported in several species including the rat (Moss et al 1975) and the mouse (Luttge & Sheets, 1977).…”

Section: Discussionmentioning

confidence: 95%

“…This reduction in plasma LH is presumably due to a reduction in LH-releasing hormone (LHRH) release (Weber, de Greef, de Koning & Vreeburg, 1983). Luteinizing hormone-releasing hormone has been reported to stimulate sexual behaviour in male and female rats (Pfaff, 1973;Moss, Dudley, Foreman & McCann, 1975) and in several species of lower vertebrates and mammals (Carter & Davis, 1977;Cheng, 1977;Luttge & Sheets, 1977;Alderete, Tokarz & Crews, 1980;Moore, Miller, Spielvogel et al 1982;Boyd & Moore, 1985), possibly including man (Winters & Troen, 1984). We have shown that, in contrast to the situation in the rat, chronic hyperprolactinaemia can increase, rather than reduce, plasma LH levels in male mice (Klemcke & Bartke, 1981;Bartke, Morgan, Clayton et al 1987) and in castrated testosteronetreated hamsters (Bartke, Matt, Siler-Khodr et al 1984 >), presumably through stimulation of endo¬ genous LHRH release.…”

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confidence: 97%

Effects of hyperprolactinaemia on male sexual behaviour in the golden hamster and mouse

Shrenker¹,

Bartke²

1987

Journal of Endocrinology

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In the male rat, hyperprolactinaemia is associated with significant reductions in plasma LH and FSH levels and in several measures of copulatory behaviour. In contrast to this situation, experimental induction of hyperprolactinaemia in male mice and hamsters is associated with an increase in plasma gonadotrophin levels. It was therefore of interest to determine the effects of hyperprolactinaemia on the copulatory behaviour of these animals. Hyperprolactinaemia was induced by transplantation of pituitaries from adult females and sexual behaviour was tested in the presence of ovariectomized, oestrogen- and progesterone-treated females. Because hyperprolactinaemia increases plasma testosterone levels in intact male hamsters, the animals were castrated and implanted with testosterone-filled silicone elastomer capsules before induction of hyperprolactinaemia. In mice of two inbred strains, DBA/2J and C57BL/6Bg, hyperprolactinaemia appeared to stimulate male sexual behaviour as shown by a significant increase in the proportion of animals mating (C57BL/6) and a significant decrease in mount (DBA/2J) and intromission (C57BL/6Bg and DBA/2J) latencies. Similarly, hyperprolactinaemia did not suppress male copulatory behaviour in the hamster. In contrast, in two experiments in which the animals were tested three times for sexual behaviour, mount or intromission latencies were significantly reduced in pituitary-grafted, as compared with sham-operated males, in the first of the tests. Thus, in the mouse and the golden hamster, experimentally induced chronic hyperprolactinaemia stimulates both gonadotrophin release and male copulatory behaviour. These observations, together with the association of suppressive effects of hyperprolactinaemia on plasma LH and FSH levels and on sexual behaviour in the male rat, suggest the possible existence of a common mechanism underlying both endocrine and behavioural effects of hyperprolactinaemia.(ABSTRACT TRUNCATED AT 250 WORDS)

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What Nature's Knockout Teaches Us about GnRH Activity: Hypogonadal Mice and Neuronal Grafts

Gibson

Wu²,

Miller³

et al. 1997

Hormones and Behavior

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Further studies on the restoration of estrogen-induced sexual receptivity in ovariectomized mice treated with dihydrotestosterone: Effects of progesterone, dihydroprogesterone and LH-RH

Cited by 18 publications

References 21 publications

Luteinizing Hormone-Releasing Hormone Involvement in the Reproductive Behavior of a Male Amphibian

Luteinizing Hormone-Releasing Hormone Involvement in the Reproductive Behavior of a Male Amphibian

Effects of hyperprolactinaemia on male sexual behaviour in the golden hamster and mouse

What Nature's Knockout Teaches Us about GnRH Activity: Hypogonadal Mice and Neuronal Grafts

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