Further study of genetic association between the TNXB locus and schizophrenia

Wang, Jiaoyan; Sun, Shilong; Zhang, Li; Wang, Zhenqi; Ye, Lin; Liu, Lin Lin; Wu, Ning; Li, Heyao; Zhang, Xuan; Wu, Jiang

doi:10.1097/ypg.0b013e3283413398

Cited by 5 publications

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“… 58 In addition, association of immune-related genes in schizophrenia has received recent attention. 59 The MHC and complement genes, together with other top-ranked SNP members of GC1, are all located on 6p21.3 ( Table 2 ). Tenascin XB, a MHC class II gene, was the top-ranked gene in GC1.…”

Section: Discussionmentioning

confidence: 99%

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Genetic association of impulsivity in young adults: a multivariate study

et al. 2014

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Impulsivity is a heritable, multifaceted construct with clinically relevant links to multiple psychopathologies. We assessed impulsivity in young adult (N~2100) participants in a longitudinal study, using self-report questionnaires and computer-based behavioral tasks. Analysis was restricted to the subset (N=426) who underwent genotyping. Multivariate association between impulsivity measures and single-nucleotide polymorphism data was implemented using parallel independent component analysis (Para-ICA). Pathways associated with multiple genes in components that correlated significantly with impulsivity phenotypes were then identified using a pathway enrichment analysis. Para-ICA revealed two significantly correlated genotype–phenotype component pairs. One impulsivity component included the reward responsiveness subscale and behavioral inhibition scale of the Behavioral-Inhibition System/Behavioral-Activation System scale, and the second impulsivity component included the non-planning subscale of the Barratt Impulsiveness Scale and the Experiential Discounting Task. Pathway analysis identified processes related to neurogenesis, nervous system signal generation/amplification, neurotransmission and immune response. We identified various genes and gene regulatory pathways associated with empirically derived impulsivity components. Our study suggests that gene networks implicated previously in brain development, neurotransmission and immune response are related to impulsive tendencies and behaviors.

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Section: Discussionmentioning

confidence: 99%

“…Tenascin XB, a MHC class II gene, was the top-ranked gene in GC1. Tenascin XB mediates interactions between cell and extracellular matrix, and has been reported to be associated with schizophrenia, 59 a disorder in which impulsivity has been identified as major problem. 60 …”

Section: Discussionmentioning

confidence: 99%

Genetic association of impulsivity in young adults: a multivariate study

et al. 2014

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“…Tenascin-X is the largest member of the tenascin family of ECM glycoproteins. It is involved in behavioral functions including anxiety, emotional learning and memory [54], and has been associated with Sz [55-57]. Fibronectin is a high molecular weight ECM glycoprotein that binds to integrin receptors and plays important roles in neuro- and synaptogenesis.…”

Section: Changes In Brain Ecm In Neurodegenerative Conditionsmentioning

confidence: 99%

Extracellular matrix proteomics in schizophrenia and Alzheimer’s disease

Sethi

Zaia

2016

Anal Bioanal Chem

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Brain extracellular matrix (ECM) is a highly organized system that consists of collagens, non-collagenous proteins, glycoproteins, hyaluronan and proteoglycans (PGs). Recognized physiological roles of ECM include developmental regulation, tissue homeostasis, cell migration, proliferation, differentiation, neuronal plasticity, and neurite outgrowth. Aberrant ECM structure is associated with brain neurodegenerative conditions. This review focuses on two neurodegenerative conditions, schizophrenia (Sz) and Alzheimer's disease (AD), and summarizes recent findings of altered ECM components, including PGs, glycosaminoglycans (GAGs), proteins and glycoproteins, and proteins and genes related to other brain components. The scope includes immunohistochemical, genomics, transcriptomics, proteomics and glycomics studies, and a critical assessment of current state of proteomics studies for neurodegenerative disorders. The intent is to summarize the ECM molecular alterations associated with neurodegenerative pathophysiology.

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“…Tenascin-X (TNX) deficiency had been well-reported to be associated with EDS (53)(54)(55)(56)(57)(58)(59)(60). While a single nucleotide polymorphism in TNX gene had been indicated to be associated with schizophrenia by Tochigi (61), the replication studies from other researchers could not find the association (62,63). To the best of our knowledge, there has been no research on high prevalence of the schizophrenia among patients with EDS.…”

Section: Mood Disorders Schizophrenia and Edsmentioning

confidence: 99%

Ehlers-Danlos Syndrome in the Field of Psychiatry: A Review

2022

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Ehlers-Danlos syndrome (EDS) comprises a series of rare hereditary connective tissue diseases characterized by joint hypermobility, joint dislocation, and hyperextensibility of the skin, as well as cardiovascular involvement. EDS is often associated with chronic widespread physical pain, which can lead to psychological pain. Poor awareness and limited diagnosis of EDS and related symptoms result in decreased self-esteem and confusion regarding physical sensation. Furthermore, EDS imposes substantial psychological burden on patients due to exercise restriction, scars, keloids, and subcutaneous fat accumulation on the extremities, which leads to parental overprotection and bullying experiences from other children at school age. Recent large-scale studies have suggested that patients with EDS have a higher risk of mood disorders than the general population. Other cohort studies indicated high prevalence of anorexia nervosa, addiction, obsessive compulsive disorder, and anxiety disorder were found in patients with EDS. Case reports instead indicated that some psychiatric disorders were secondary symptoms due to physical problems from EDS. Therefore, psychiatrists must be more knowledgeable and proactive about EDS in their practice. We review the previous case reports and literature for patients with EDS, along with our own case of complicated psychiatric problems, which are strongly related to early stressful situations through childhood and adolescence. This is to aid general psychiatrists in the discussion of appropriate medical management in such infrequent, yet challenging conditions.

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Further study of genetic association between the TNXB locus and schizophrenia

Cited by 5 publications

References 0 publications

Genetic association of impulsivity in young adults: a multivariate study

Genetic association of impulsivity in young adults: a multivariate study

Extracellular matrix proteomics in schizophrenia and Alzheimer’s disease

Ehlers-Danlos Syndrome in the Field of Psychiatry: A Review

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