1967
DOI: 10.1038/bjc.1967.42
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Further tests for carcinogenesis using newborn mice: 2-naphthylamine, 2-naphthylhydroxylamine, 2-acetylaminofluorene and ethyl methane sulphonate.

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Cited by 24 publications
(6 citation statements)
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“…A subsequent study reported in 1961 by the same group (2) indicated that Swiss newborn mice receiving benzo[a]pyrene, 3-methylcholanthrene, dibenz[a,h]anthracene, or urethane (ethyl carbamate) developed malignant lymphoma and pulmonary tumors. Throughout the early to mid 1960s, the susceptibility of neonatal mice of different strains and dosing regimens to a variety of chemicals of various structures was widely studied (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). In general, it was shown that different strains of neonatal mice were highly susceptible to chemicallyinduced tumor formation.…”
mentioning
confidence: 99%
“…A subsequent study reported in 1961 by the same group (2) indicated that Swiss newborn mice receiving benzo[a]pyrene, 3-methylcholanthrene, dibenz[a,h]anthracene, or urethane (ethyl carbamate) developed malignant lymphoma and pulmonary tumors. Throughout the early to mid 1960s, the susceptibility of neonatal mice of different strains and dosing regimens to a variety of chemicals of various structures was widely studied (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). In general, it was shown that different strains of neonatal mice were highly susceptible to chemicallyinduced tumor formation.…”
mentioning
confidence: 99%
“…In 9 out of 41 surviving mice, and in 4 of 48 animals belonging to the control group, lung adenomas were observed, this number not being significant. The authors concluded that the metabolic system of newborn mice was immature and no tumors were observed [97].…”
Section: Subcutaneous Injectionsmentioning
confidence: 99%
“…While 4-aminobiphenyl and its hydroxylated deriva tives are hepatocarcinogenic following administration to newborn mice [7], prior to the present studies there were no available data on the carcinogenicity in infant mice of AAB or N-OH-AAB, both of which, however, induce breast cancer in rats [14], Numerous studies have been done in adult mice with AAF and with N-OH-AAF, but there have been only limited studies on the carcinogenicity in newborn mice [1,6,9,10,14,16], Flepatomas were induced in suckling A/Ha mice by oral administ.ation of a total dose of 7 mg AAF [9], and in suckling (C57BL/6 x A/J)< hybrid mice by 1 mg N-OH-AAF [10], Lower doses, 100,Mg, of AAF failed to induce hepatomas in A/Ha mice following administration on day 1 of life [16], although the same dosage in newborn ICR/JCL mice induced a high incidence of hepatomas in males [6],…”
Section: Discussionmentioning
confidence: 99%
“…Oral administra tion of AAF to five different strains of adult mice in duced tumors of the bladder, liver, and breast after 40-50 weeks or more treatment [1]; the tumor in cidence was dose, strain, and sex dependent. Both AAF anditsN-hydroxy-2-acetylaminofluorene (N-OH-AAF) metabolite were hepatocarcinogenic when administered orally to suckling A/He or (C57BL/6 x A/J)F] mice [9,10], Lung tumors were induced in BALB/c mice following neonatal injection of AAF [16], Single subcutaneous injection of AAF or N-OH-AAF in in fant 1CR/JCL mice induced hepatomas, with a higher incidence in males than females [6], N-hydroxylation of aromatic amines, such as AAF, is prerequisite to their carcinogenicity. For this reason, it was decided to test the carcinogenic effects of AAF and N-OH-AAF in neonatal mice following their administration alone, or in combination with the liver microsomal enzyme inhibitor piperonyl butoxide (PB) [5,8,13).…”
Section: Introductionmentioning
confidence: 99%