Fusarium species central nervous system infection

Abstract

Purpose of review Fusarium species are an increasingly important cause of meningitis and invasive disease in immunocompromised patients as well as in otherwise healthy patients as observed in two recent healthcare-associated outbreaks. This review summarizes recently published information on treatment and diagnosis of this infection. Recent findings Incidence of Fusarium species meningitis and invasive fusariosis are increasing. Molecular techniques are improving the speed of diagnosis. New antifungal agents in development show good in vitro activity against some Fusarium species. New technologies, including cerebrospinal fluid (CSF) filtration, may play a role in treatment of central nervous system (CNS) disease. Due to the continued prime importance of the host immune system in recovery, immunomodulatory treatments may play a role in treatment. Summary The overall incidence of CNS fusariosis is increasing with a continued poor prognosis, but new diagnostic and treatment modalities are in development which may offer improvements.

Phytotoxic Isocassadiene-Type Diterpenoids from Tomato Fusarium Crown and Root Rot Pathogen Fusarium oxysporum f. sp. radicis-lycopersici

“…emerging as the human pathogens in immunocompromised individuals. 5 Fusarium mycotoxins comprised a diverse array of metabolite families, characterized by varied structures and biological activities. Notable examples included fusaric acid, 6 fumonisins, 7 trichothecenes, 8 zearalenone, 9 beauvericin, 10 and enniatins.…”

“…Subfraction E13 (11.9 mg) was separated by semipreparative HPLC using MeCN−H 2 O (40:60) as an eluent to afford 6 (4. 5 The structure of 1 was solved by direct methods using SHELXS-97 and refined with full-matrix least-squares calculations on F2 using SHELXL-97. 25 Crystallographic data for 1 were deposited in the Cambridge Crystallographic Data Centre (deposition number: 2284201).…”