Fused Cyanopyrimidines: Part Ii Synthesis and Reactions of Fused Cyanopyrimidine Derivatives as Affecting Enzymatic Agents

Synthesis of Some New Biologically Active 2,3-Disubstituted Quinazolin-4-Ones

“…Substituted pyrimidinone and thioxopyrimidinone derivatives were found to exhibit antimicrobial activities [11,12], thus, 2a,b were easily cyclocondensed with urea or thiourea in boiling ethanol with a few drops of acetic acid to give 3,4,5,6-tetrahydro-4,6-disubstituted pyrimidin-2(l/f) ones (10a,c) or 3,4,5,6-tetrahydro-4,6-disubstituted pyrimidin-2-(l/f)-thiones (10b,d) respectively.…”

Synthesis and Antimicrobial Activity of New Functionalized Derivatives of [1,2,4]Triazolo[4,3‐a]pyrimidin‐5(1H)‐one.

“…Thus, treatment of 1 with α-chloroacetoacetanilide in ethanol in the presence of sodium ethoxide afforded the substituted product 8. For example, it has been reported that cyclization of 2-substituted uracil derivatives having no substituent at N-3 proceeds regioselectively to give the respective 1,2,4-triazolo[4,3-a]pyrimidin-5(1H)ones [18][19][20][21]. Treatment of the latter with sodium ethoxide in refluxing ethanol, in an attempt to effect Japp-Klingemann cleavage of the acetyl group in 9 [17] to give the respective thiohydrazonate (3g), was found to give 5g directly (Scheme 2).…”

Chemistry of 1,3-thiazin-4-ones and their derivatives, 1995 - mid-2018

“…Reaction of cyclic thiourea 378 with malonic acid 377 and acetyl chloride in DMF gave the 6-oxo-bfused compound 380 by condensation of both malonic acid groups (Scheme 114). 209 There was a C=O at C6 of 380. The paper does not comment on the reaction.…”