Fusidic Acid Resistance Determinants in Methicillin-Resistant &lt;b&gt;&lt;i&gt;Staphylococcus aureus&lt;/i&gt;&lt;/b&gt; Isolated in Kuwait Hospitals

Boloki, H.; Al-Musaileem, Wasmiyah F.; Verghese, T.; Udo, Edet E.

doi:10.1159/000518408

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…The results presented in current research were in agreement with earlier reports from European countries [13], Kuwait [8], and Taiwan [14]. Other fusA mutations identified in present report (H457Y), amino acid change at position 457 from the histidine residue to tyrosine, were described earlier [8,13,27]. In contrast to the observations of Castanheira et al, [13], Zhao et al, [24], and McLaws et al, [25], we reported high prevalence of H457Y mutation which was related to elevated fusidic acid MIC values 128 μg ml À1 .…”

Section: Discussionsupporting

confidence: 93%

“…Other detected mutations in fusA included H457Q mutation (4.1%), H457Y mutation (4.1%), and L461S mutation (4.1%) [27]. The results presented in current research were in agreement with earlier reports from European countries [13], Kuwait [8], and Taiwan [14]. Other fusA mutations identified in present report (H457Y), amino acid change at position 457 from the histidine residue to tyrosine, were described earlier [8,13,27].…”

Section: Discussionsupporting

confidence: 91%

“…Shortly after the introduction of FA in the 1960s, several published data exhibited increased prevalence of resistance to this antibiotic at a low level. However, recently, a significant trend of FA resistance to be on the increase has been reported with increased duration of use which can hamper the effectiveness of this therapeutic option [6][7][8][9]. FA via bound to elongation factor G (EF-G) and preventing its release from the ribosome leads to inhibition of protein synthesis.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and genetic characteristics of fusidic acid resistant Staphylococcus aureus clinical isolates: Emergence of t030 strains carrying fusB in Tehran, Iran

Goudarzi

Seyedjavadi

Bagheri

et al. 2023

AMicr

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The literature on fusidic acid resistant Staphylococcus aureus strains is scarce in Iran, although the emergence of these strains in health care settings is increasing. This descriptive cross-sectional study was conducted on 68 fusidic acid resistant S. aureus strains to learn about the molecular characteristics and antimicrobial resistance of strains isolated from hospitalized patients. In the present study, the prevalence of resistance to fusidic acid in S. aureus isolates was 15.1%. Fusidic acid resistance determinative factors (fusB, fusC and fusD) were identified by multiplex PCR assay. To detect the existence of fusA and fusE determinants and their mutation status, amplifications and sequencing were performed. Molecular characterization of fusidic acid resistant isolates was investigated by SCCmec and spa typing methods. All strains were MRSA and multi drug resistant. Two (2.9%) and 31 (45.6%) isolates were resistant to vancomycin and mupirocin respectively. The SCCmec type IV was highly prevalent representing 50% followed by types III (51.5%), and SCCmec types II (13.2%). fusB, was the most predominant acquired gene (66.2%) followed by fusC (19.1%), and fusA (14.7%). The mutations in fusA were present in 10 isolates with 5 (50%) having L461K mutation showing fusidic acid MIC values of ≥256 μg ml−1 followed by H457Y (40%), and H457Q (10%) showing fusidic acid MIC values of 128 and 64 μg ml−1 respectively. Isolates were allocated to ten particular t030 (22.1%), t037 (14.6%), t408 (11.8%), t064 (11.8%), t008 (10.3%), t002 (8.8%), t005 (5.9%), t790 (5.9%), t318 (4.4%), and t018 (4.4%) spa types. fusA positive isolates were assigned to particular spa types t002 (60%), and t005 (40%). There may be be a spreading of fusidic acid resistance among MRSA, creating worrying public concern. This research notes the importance of adequate data of local prevalence of FA-resistant MRSA in Iran for taking appropriate measures to treat, control and reduce the incidence of these isolates.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Prevalence and genetic characteristics of fusidic acid resistant Staphylococcus aureus clinical isolates: Emergence of t030 strains carrying fusB in Tehran, Iran

Goudarzi

Seyedjavadi

Bagheri

et al. 2023

AMicr

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Liposome drug delivery in combating the widespread topical antibiotic resistance: a narrative review

Rizkita,

Putri,

Farid

et al. 2024

Beni-Suef Univ J Basic Appl Sci

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Background The increasing trend of antibiotic resistance has posed challenges for scientists, especially in developing better drug formulations. The discovery of new antibiotics could take years. Therefore, the management of an ideal drug delivery system has become a primary focus nowadays. Main body of abstract Almost all skin diseases could be treated with the administration of topical drugs, especially infectious skin diseases. The increasing cases of antimicrobial resistance require innovative strategies and actions. In dermatokinetics, achieving optimal drug concentrations in the deepest layers of skin tissue is a significant challenge. Human skin has remarkably complex characteristics, presenting a major obstacle in efficiently maintaining drug efficacy. Nanocarriers are an important part of nanomedicine which provide excellent drug penetration through various drug delivery systems. Lipid-based nanovesicles, such as liposome, are the oldest and most potential nanovesicles for such a purpose. Several studies have shown the efficacy of liposome-contained antibiotics and offered the lowest microbial inhibition concentration (MIC). It is suggested that liposome also delivers greater drug accumulation compared to blank drugs. Short conclusion Liposome is a flexible lipid-based drug delivery that enhances drug permeation through skin tissue by mimicking the lipid bilayer system of the organ. It is non-toxic, less immunogenic, and easily degraded by enzyme. The incorporation of liposome into antibiotics may reduce the inefficient drug dosage since the encapsulation will protect the active compounds prior to being released from the vehicle. Thus, the lowest MIC and less clinical side effects will be obtained. Graphical abstract

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Fusidic Acid Resistance Determinants in Methicillin-Resistant <b><i>Staphylococcus aureus</i></b> Isolated in Kuwait Hospitals

Cited by 2 publications

References 29 publications

Prevalence and genetic characteristics of fusidic acid resistant Staphylococcus aureus clinical isolates: Emergence of t030 strains carrying fusB in Tehran, Iran

Prevalence and genetic characteristics of fusidic acid resistant Staphylococcus aureus clinical isolates: Emergence of t030 strains carrying fusB in Tehran, Iran

Liposome drug delivery in combating the widespread topical antibiotic resistance: a narrative review

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