Fusidilactones, a New Group of Polycyclic Lactones from an Endophyte, Fusidium sp.

Krohn, Karsten; Biele, Carsten; Drogies, Karl‐Heinz; Steingröver, Klaus; Aust, Hans-Jürgen; Draeger, Siegfried; Schulz, Barbara

doi:10.1002/1099-0690(200207)2002:14<2331::aid-ejoc2331>3.0.co;2-p

Cited by 64 publications

(37 citation statements)

References 10 publications

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“…Endophytic fungi are potential sources of novel natural products, partly due to the richness of hitherto unknown species (sensu Schulz et al 2002;Krohn et al 2002;Tejesvi et al 2007Tejesvi et al , 2009Huang et al 2008). In this study, 33 distinct taxa belonging to a wide range of taxonomic groups were identified from the 18S region of the sequenced isolates.…”

Section: Endophyte Richness and Ecologymentioning

confidence: 99%

“…Endophytes associated with trees are unlikely to include systemic symbionts similar to those found in pooid grasses. However, their diversity, novelty and possible bioactive roles indicate that they are likely to produce various currently unknown metabolites with wide potential applications (Stierle et al 1993;Strobel et al 2004;Huang et al 2008); indeed several interesting substances have already been discovered in rational screenings Krohn et al 2002;Mitchell et al 2008). Trees may also benefit from the presence of endophytes, because they restrict the growth and survival of insect herbivores (see, for example : Carroll 1995;Webber 1981;Saikkonen et al 1996;Faeth and Hammon 1997;Wilson and Carroll 1997), or increase pathogen resistance in the host (Arnold et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Endophytic fungi in European aspen (Populus tremula) leaves—diversity, detection, and a suggested correlation with herbivory resistance

et al. 2010

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Fungal endophytes are found in most seed plants, but their ecological function mainly remains elusive, except in pooid (or clavicipitalean) systems. The diversity and dynamics of endophytes in non clavicipitalean plants make studies of their ecological function challenging. This paper describes the advantage of using molecular techniques to survey the ecological function of endophytes in Populus tremula clones. About 1,000 endophyte isolates were distinguished using traditional methods; these isolates represented approximately 100 morphologically distinct groups. We generated 73 DNA-sequences (18S and ITS rDNA) from these groups and determined 33 distinct taxa. They represented the Basidiomycota and Ascomycota, including diverse Sordariomycetes and Dothideomycetes, and three sequences that were identified, by their ITS sequences, as a species of Epicoccum (a genus of supposedly unknown relation within the Ascomycota) were placed within the Pleosporales, in the 18S phylogeny. Primer pairs were designed for eleven of the fungi. Of these, three primers produced bands for a subset of Aspen samples. The primer pairs allowed endophytes in field samples to be readily identified, with a detection limit of 0.15 percent fungal DNA. The presence of fungi in Aspen clones was related to field damage by herbivores and the pathogen Venturia tremula. A negative association was found in two separate surveys between Aureobasidium sp. and herbivore damage, but we found no evidence that endophyte presence was related to a history of Venturia symptoms. This approach promises to enhance greatly the scope for qualitative and quantitative detection of endophyte communities, and to improve our ability to elucidate the ecological function of non clavicipitalean endophytes.

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Section: Endophyte Richness and Ecologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endophytic fungi in European aspen (Populus tremula) leaves—diversity, detection, and a suggested correlation with herbivory resistance

et al. 2010

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“…Several compounds having the furo[3,4- b ]pyran-5-one bicyclic ring system have been reported from fungi with diverse biological activities, including antibacterial and cytotoxic activities. 21–26 …”

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confidence: 99%

Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species

El‐Elimat

Figueroa

Raja

et al. 2013

Tetrahedron Letters

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An organic extract of a filamentous fungus (MSX 58801), identified as a Volutella sp. (Hypocreales, Ascomycota), displayed moderate cytotoxic activity against NCI-H460 human large cell lung carcinoma. Bioactivity-directed fractionation led to the isolation of three γ-lactones having the furo[3,4-b]pyran-5-one bicyclic ring system [waol A (1), trans-dihydrowaol A (2), and cis-dihydrowaol A (3)]. The structures were elucidated using a set of spectroscopic and spectrometric techniques; the absolute configuration of 2 was established via a modified Mosher’s ester method. Compounds 1 and 2 were evaluated for cytotoxicity against a human cancer cell panel.

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“…Isolation of natural products: biologically active metabolites from phytopathogenic and endophytic fungi of terrestric and marine origin (10, 11). 9,10 In cooperation the chemical constituents of medicinal plant extracts from Africa and Asia are also investigated. Selected publications…”

Section: New Methodology: Transition-metal Catalyzed Oxidations and Rmentioning

confidence: 99%

A Tribute to Prof. Karsten Krohn

Schantl¹

2004

Arkivoc

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Fusidilactones, a New Group of Polycyclic Lactones from an Endophyte, Fusidium sp.

Cited by 64 publications

References 10 publications

Endophytic fungi in European aspen (Populus tremula) leaves—diversity, detection, and a suggested correlation with herbivory resistance

Endophytic fungi in European aspen (Populus tremula) leaves—diversity, detection, and a suggested correlation with herbivory resistance

Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species

A Tribute to Prof. Karsten Krohn

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