Nuclear reactions leading to formation of new Nuclear reactions leading to formation of new superheavy elements and isotopes are discussed. The scope superheavy elements and isotopes are discussed. The scope and limitations of different nuclear reactions (cold and hot and limitations of different nuclear reactions (cold and hot synthesis, fusion of fission fragments, transfer reactions and synthesis, fusion of fission fragments, transfer reactions and reactions with radioactive ion beams) are analyzed, trying reactions with radioactive ion beams) are analyzed, trying to find most promising reactions which may be used at to find most promising reactions which may be used at available facilities. The bibliography includes 70 references available facilities. The bibliography includes 70 references.. I. Historical remarks We begin our discussion of the Periodic Table with some historical remarks about Dmitri Medeleev and Julius Meyer, the discoverers of order and chemical systematics of the elements. The two fathers of the Periodic System, Dmitri Ivanovich Mendeleev (27.1.1834 ± 20.1.1907) and Julius Lothar Meyer (19.3.1830 ± 11.4.1895) were contemporaries close in age. Although coming from different origins, they shared part of their education in science. Meyer was virtually born into a scientific career. He came from a medical family of Oldenburg, Germany, and first pursued a medical degree. In medical school he became interested in chemistry, especially physiological topics like gases in the blood. He earned a medical doctorate at WuÈ rzburg university and subsequently also a physics