Fusion imaging with contrast-enhanced ultrasonography for evaluating the early therapeutic efficacy of radiofrequency ablation for small hypervascular hepatocellular carcinomas with iso-echoic or unclear margins on conventional ultrasonography

Nishigori, Shuhei; Numata, Kazushi; Irie, Kazuhiro; Fukuda, Hiroyuki; Chuma, Makoto; Maeda, Shin

doi:10.1007/s10396-018-0861-6

Cited by 19 publications

(12 citation statements)

References 38 publications

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“…Low-MI harmonic imaging is obtained using conventional gray-scale US images combined with a newly developed transducer, which consists of wide-band phase inversion harmonic gray-scale imaging, and provides a high spatial resolution and deep penetration with high frame rates of 24-30 frames per second [48,[73][74][75]. Using this transducer, once the target lesion is detected, the MI can be reduced to around 0.18-0.28 manually.…”

Section: Low-mechanical Index Harmonic Imagingmentioning

confidence: 99%

“…CQ13: Is Sonazoid CEUS helpful to perform local ablation therapy for liver tumors? Locoregional therapies, which conventionally include ablation, whatever the modality used, and transarterial chemoembolization (TACE), play a key role in the management of patients with HCC [75,171,172]. For systemic therapy, CEUS may enable early prediction and monitoring of treatment response [173].…”

Section: Combined Fusion Imaging and Contrast-enhanced Ultrasoundmentioning

confidence: 99%

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The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid

et al. 2020

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The first edition of the guidelines for the use of ultrasound contrast agents was published in 2004, dealing with liver applications. The second edition of the guidelines in 2008 reflected changes in the available contrast agents and updated the guidelines for the liver, as well as implementing some nonliver applications. The third edition of the contrast-enhanced ultrasound (CEUS) guidelines was the joint World Federation for Ultrasound in Medicine and Biology-European Federation of Societies for Ultrasound in Medicine and Biology (WFUMB-EFSUMB) venture in conjunction with other regional US societies such as Asian Federation of Societies for Ultrasound in Medicine and Biology, resulting in a simultaneous duplicate on liver CEUS in the official journals of both WFUMB and EFSUMB in 2013. However, no guidelines were described mainly for Sonazoid due to limited clinical experience only in Japan and Korea. The new proposed consensus statements and recommendations provide general advice on the use of Sonazoid and are intended to create standard protocols for the use and administration of Sonazoid in hepatic and pancreatobiliary applications in Asian patients and to improve patient management.

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Section: Low-mechanical Index Harmonic Imagingmentioning

confidence: 99%

Section: Combined Fusion Imaging and Contrast-enhanced Ultrasoundmentioning

confidence: 99%

The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid

et al. 2020

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“…To date, however, no research has been done to comparatively evaluate which modality is better for guidance during RFA. More importantly, although EOB-MRI/US FI has been reported by some articles to have the ability to guide interventional operations for HCC, especially for small or atypical HCC lesions [20,21], regrettably, to the best of our knowledge, no study has focused on ablating the valuable prognosis-related HBP findings.…”

Section: Introductionmentioning

confidence: 99%

Intraprocedurally EOB-MRI/US fusion imaging focusing on hepatobiliary phase findings can help to reduce the recurrence of hepatocellular carcinoma after radiofrequency ablation

Wang

Numata

Nihonmatsu

et al. 2020

International Journal of Hyperthermia

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Background & aims: To explore the ability of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging (EOB-MRI)/ultrasound (US) fusion imaging (FI) to improve the prognosis of radiofrequency ablation (RFA) by ablating the characteristic findings of hepatocellular carcinoma (HCC) in hepatobiliary phase (HBP) imaging. Methods: We retrospectively recruited 115 solitary HCC lesions with size of (15.9 ± 4.6) mm. They were all treated by RFA and preoperative EOB-MRI. According to the modalities guiding RFA performance, the lesions were grouped into contrast enhanced US (CEUS)/US guidance group and EOB-MRI/US FI guidance group. For the latter group, the ablation scope was set to cover the HBP findings (peritumoral hypointensity and irregular protruding margin). The presence of HBP findings, the modalities guided RFA, the recurrence rate were observed. Results: After an average follow-up of 377 days, local tumor progression (LTP) and intrahepatic distant recurrence (IDR) were 14.8% and 38.4%, respectively. The lesions having HBP findings exhibited a higher recurrence rate (73.7%) than the lesions without HBP findings (42.9%) (p ¼ 0.002) and a low overall recurrence-free curve using the Kaplan-Meier method (p ¼ 0.038). Using EOB-MRI/US FI as guidance, there was no difference in the recurrence rate between the groups with and without HBP findings (p ¼ 0.799). In lesions with HBP findings, RFA guided by EOB-MRI/US FI (53.8%) produced a lower recurrence rate than CEUS/US (84.0%) (p ¼ 0.045). Conclusions: The intraprocedurally application of EOB-MRI/US FI to determine ablation scope according to HBP findings is feasible and beneficial for prognosis of RFA.

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“…Fusion imaging combining CEUS and arterial-phase CECT as reference appears to be a useful method for evaluating the therapeutic efficacy of RFA for hypervascular HCCs detected using conventional US [10]. Fusion imaging combining CEUS and hepatobiliary-phase CEMRI also appears to be useful for evaluating the therapeutic efficacy of RFA for HCCs identified as having isoechoic or unclear margins by conventional US [12]. The usefulness of fusion imaging combining CEUS and CECT/CEMRI for evaluating the therapeutic efficacy of RFA has been reported by several investigators [13,14].…”

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confidence: 99%

Use of intra-procedural fusion imaging combining contrast-enhanced ultrasound using a perflubutane-based contrast agent and auto sweep three-dimensional ultrasound for guiding radiofrequency ablation and evaluating its efficacy in patients with hepatocellular carcinoma

Sanga

Numata

Nihonmatsu

et al. 2020

International Journal of Hyperthermia

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Fusion imaging with contrast-enhanced ultrasonography for evaluating the early therapeutic efficacy of radiofrequency ablation for small hypervascular hepatocellular carcinomas with iso-echoic or unclear margins on conventional ultrasonography

Abstract: Fusion imaging with CEUS appears to be a useful method for the early evaluation of the efficacy of RFA for the treatment of HCCs with iso-echoic or unclear margins on conventional US.

Cited by 19 publications

References 38 publications

The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid

The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid

Intraprocedurally EOB-MRI/US fusion imaging focusing on hepatobiliary phase findings can help to reduce the recurrence of hepatocellular carcinoma after radiofrequency ablation

Use of intra-procedural fusion imaging combining contrast-enhanced ultrasound using a perflubutane-based contrast agent and auto sweep three-dimensional ultrasound for guiding radiofrequency ablation and evaluating its efficacy in patients with hepatocellular carcinoma

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