Fusion of positron emission tomography and coronary computed tomographic angiography identifies fluorine 18 fluorodeoxyglucose uptake in the left main coronary artery soft plaque

Alexánderson, Erick; Slomka, Piotr J.; Cheng, Victor; Meave, Aloha; Saldaña, Yolanda; García-Rojas, Leonardo; Berman, Daniel S.

doi:10.1007/bf03007367

Cited by 41 publications

(13 citation statements)

References 2 publications

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“…They noted coronary FDG uptake in 45% of patients, most commonly in the left main coronary artery, and that patients with a history of coronary artery disease had a fourfold greater odds of coronary FDG uptake. A similar observation was noted by Alexanderson et al [48], who reported significant FDG uptake in the left main coronary artery in a patient originally studied for tumor staging, which colocalized with a large noncalcified plaque in the left main coronary artery.…”

Section: Feasibility Of Fdg Imaging For Inflammationsupporting

confidence: 54%

Imaging of Coronary Inflammation with FDG-PET: Feasibility and Clinical Hurdles

Rogers

Tawakol

2011

Curr Cardiol Rep

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Conventional algorithms and noninvasive imaging tests for the identification of stable, hemodynamically significant coronary artery disease offer little insight into the detection of potentially vulnerable and inflamed coronary plaques, those most likely to rupture and cause acute coronary syndromes. Positron emission tomography (PET) with fluorodeoxyglucose (FDG) serves as a potential novel modality for the identification of plaque inflammation, as initial studies in animal and human studies have demonstrated that FDG uptake correlates with macrophage accumulation and inflammation. Therapy with anti-inflammatory agents has also been demonstrated in the arterial vasculature to reduce plaque FDG uptake. Although imaging of coronary inflammation with FDG-PET holds tremendous promise, several hurdles remain to be surmounted prior to widespread clinical application.

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Section: Feasibility Of Fdg Imaging For Inflammationsupporting

confidence: 54%

Imaging of Coronary Inflammation with FDG-PET: Feasibility and Clinical Hurdles

Rogers

Tawakol

2011

Curr Cardiol Rep

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“…Stand-alone (e.g., MRI) or hybrid [e.g., positron emission tomography (PET) coupled with CTA] techniques using novel nanoparticles and agents can be used to trace regions of intense inflammation, macrophage trafficking, endothelial activation or protease activity [72] and possibly predict culprit lesions of subsequent acute events. First-inhuman applications demonstrate the great potential of this emerging field in providing measures of plaque vulnerability in coronary arteries [73,74 ] and indicate the need for intensifying the technological efforts to improve the resolution and quantitative accuracy of such techniques, especially for imaging the coronary arterial tree.…”

Section: Constrictmentioning

confidence: 99%

In-vivo assessment of the natural history of coronary atherosclerosis: vascular remodeling and endothelial shear stress determine the complexity of atherosclerotic disease progression

Papafaklis

Koskinas

Chatzizisis

et al. 2010

Current Opinion in Cardiology

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“…Recently, new applications for cardiac PET have come up as animal embryonic stem cell grafting in myocardium 1 and human vulnerable coronary plaque imaging. [2][3][4] The new applications aim to detect smaller spatial areas of the heart than routine applications and thus need novel, spatially accurate, PET imaging process. For example, the imaging of vulnerable coronary plaques focuses on volumes ranging from 30 to 150 mm 3 .…”

Section: Introductionmentioning

confidence: 99%