Fusion rate of Escherichia coli-derived recombinant human bone morphogenetic protein-2 compared with local bone autograft in posterior lumbar interbody fusion for degenerative lumbar disorders

Park, Sangman; Jeong, Yeong Ha; Ha, Byeong Jin; Yoo, Byung Su; Kim, Soo-Heon; Lee, Chang Kyu; Yi, Seong; Ha, Yoon; Kh, Kim; Shin, Dong Ah

doi:10.1016/j.spinee.2023.07.017

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…Described by King in 1948 1 and introduced by Roy-Camille et al for lumbar spinal fusion in 1986, 2 the use of screws has become increasingly widespread in spinal surgery for various vertebral diseases. The accuracy and safety of screws were well established, [3][4][5] while complications were also indicated intraoperatively or postoperatively. The common complications of internal fixation include deep wound infection, screw loosening, breakage, and so on.…”

Section: Introductionmentioning

confidence: 99%

Diabetes‐related Screw Loosening: The Distinction of Surgical Sites and the Relationship among Diabetes, Implant Stabilization and Clinical Outcomes

Wang,

et al. 2023

Orthopaedic Surgery

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ObjectivesDiabetes mellitus (DM) is correlated with poor clinical outcomes in spinal surgery. However, the effect of it on screw stabilization has not been investigated. The aim of this study was to evaluate the screw loosening rate and postoperative outcomes in diabetic patients and to identify potential risk factors associated with loosening.MethodsThis was a retrospective study. Two hundred and forty‐three patients who received cervical or lumbar internal fixation between 2015 and 2019 were enrolled. Screw loosening was assessed on radiography, and clinical outcomes were evaluated by the improvement of visual analogue scale (VAS), Oswestry disability index (ODI) or Japanese Orthopaedic Association (JOA) scores. The relationship of DM, screw loosening and clinical outcomes were analyzed with chi‐square tests and regression analyses.ResultsOne hundred and twenty‐two patients (50.2%) with diabetes were included in this study. Diabetes led to the increase of the rate of screw loosening in the lumbar spine, while the loosening rate did not vary significantly in the cervical spine. The occurrence of screw loosening in the lumbar spine was more likely to be associated with clinical outcomes for motor performance including walking and sitting. However, no significant effect on JOA and VAS scores in the cervical spine of screw loosening was found. Moreover, the history of DM affected the outcomes of the patients who underwent spinal surgery.ConclusionDM had an adverse effect on screw stabilization. The impaired improvement of clinical outcomes in diabetics after spinal surgery was related to screw loosening. In addition to the direct effects on operative wounds and neural function, the impact on the screws due to DM was also worth noting.

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Section: Introductionmentioning

confidence: 99%

Diabetes‐related Screw Loosening: The Distinction of Surgical Sites and the Relationship among Diabetes, Implant Stabilization and Clinical Outcomes

Wang,

et al. 2023

Orthopaedic Surgery

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Comparing the osteogenesis outcomes of different lumbar interbody fusions (A/O/X/T/PLIF) by evaluating their mechano-driven fusion processes

Lu,

Sun,

Xia

et al. 2024

Computers in Biology and Medicine

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Comparison of Hounsfield Unit, Vertebral Bone Quality, and Dual-Energy X-Ray Absorptiometry T-Score for Predicting Cage Subsidence After Posterior Lumbar Interbody Fusion

Wang,

Zhang,

Tong

et al. 2024

Global Spine Journal

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Study design Retrospective cohort study. Objectives To compare Hounsfield unit (HU), vertebral bone quality (VBQ), and dual-energy X-ray absorptiometry (DEXA) T-score in predicting cage subsidence (CS) after posterior lumbar interbody fusion. Methods We retrospectively reviewed patients undergoing PLIF and measured L4 HU and VBQ. Baseline characteristics between CS and non-CS groups were compared. Multiple logistic regression analysis was used to identify risk factors for CS. Receiver operating characteristic (ROC) curves were used to explore the predictive value of variables for CS. Subgroup analysis was conducted for patients with available DEXA results. Results Eighty-four patients were analyzed. The subsidence group was older, with lower L4 HU (92.6 (35.4) vs 130.8 (47.8), P < 0.001) and higher VBQ (3.30 (0.64) vs 2.99 (0.63), P = 0.041) compared to the non-CS group. Low L4 HU (OR 0.979, P = 0.022) was an independent risk factor for subsidence, while VBQ was not. ROC analysis indicated that L4 HU (AUC = 0.733, P < 0.001) exhibited superior predictive performance compared to VBQ (AUC = 0.643, P = 0.032). Subgroup analysis in patients with DEXA showed that the femoral neck T-score (AUC = 0.67, P = 0.037) could differentiate CS, with L4 HU exhibiting the highest predictive ability (AUC = 0.778, P < 0.001), both outperforming VBQ (AUC = 0.645, P = 0.075). Conclusions Among the three BMD parameters, only low L4 HU could be an independent risk factor for CS. Preoperative HU is mandatory in patients at risk for osteoporosis when undergoing spine surgery.

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Fusion rate of Escherichia coli-derived recombinant human bone morphogenetic protein-2 compared with local bone autograft in posterior lumbar interbody fusion for degenerative lumbar disorders

Cited by 3 publications

References 43 publications

Diabetes‐related Screw Loosening: The Distinction of Surgical Sites and the Relationship among Diabetes, Implant Stabilization and Clinical Outcomes

Diabetes‐related Screw Loosening: The Distinction of Surgical Sites and the Relationship among Diabetes, Implant Stabilization and Clinical Outcomes

Comparing the osteogenesis outcomes of different lumbar interbody fusions (A/O/X/T/PLIF) by evaluating their mechano-driven fusion processes

Comparison of Hounsfield Unit, Vertebral Bone Quality, and Dual-Energy X-Ray Absorptiometry T-Score for Predicting Cage Subsidence After Posterior Lumbar Interbody Fusion

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