Fusions of the SYT and SSX genes in synovial sarcoma

E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma

“…All five SS cases with E-cadherin missense mutations had the SYT-SSX1 fusion transcript (Fisher's exact test; P ¼ 0.07, Table 2). SYT-SSX1 are more likely to show biphasic histology than SYT-SSX2 tumors (Ladanyi, 2001), but interestingly the five SYT-SSX1 SS cases with …”

“…It has been shown that almost all of the biphasic tumors contain the SYT--SSX1 fusion, whereas tumors with SYT-SSX2 rarely exhibit biphasic histology . Therefore, it has been suggested that subtle functional differences between SYT-SSX1 and SYT-SSX2 may impact on epithelial differentiation in these sarcomas (Ladanyi, 2001); however, this model awaits experimental confirmation.…”

SYT-SSX1 (Synovial Sarcoma Translocated) Regulates PIASy Ligase Activity to Cause Overexpression of NCOA3 Protein

“…Synovial sarcoma is an aggressive soft tissue tumor that accounts for about 7-10% of all human sarcomas (1). It has a characteristic translocation between chromosomes 18 and X.…”

Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration

“…1,2 Synovial sarcoma possesses a specific chromosomal translocation between chromosomes (chr) 18 and X, forming a chimeric gene fusing SYT (synovial sarcoma translocation) on chr 18 to SSX (synovial sarcoma X break point) on chr X. 3 The translocation found in synovial sarcoma removes the last eight amino acids of SYT and fuses it to the C-terminal portion of the SSX to yield a SYT-SSX fusion protein.…”