2003
DOI: 10.3171/jns.2003.99.4.0693
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Fusobacterial brain abscess: a review of five cases and an analysis of possible pathogenesis

Abstract: Some fusobacterial brain abscesses may be associated with a paradoxical postoperative deterioration, which is probably due to intensified inflammation following treatment. The blood-borne dissemination and invasive behavior of fusobacteria likely initiate such a brain abscess, and further seeding of other synergic bacteria leads to a polymicrobic abscess.

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Cited by 45 publications
(33 citation statements)
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“…It is common in dental plaque (Bolstad et al 1996;Ximenez-Fyvie et al 2000), and there is a well-established association between F. nucleatum and periodontitis (Signat et al 2011). Anecdotally, F. nucleatum has been found to cause cerebral abscesses (Kai et al 2008) and pericarditis (Han et al 2003), and it is one of the Fusobacterium species responsible for Lemierre's syndrome, a rare form of thrombophlebitis (Weeks et al 2010). More recently, various Fusobacteria including F. nucleatum have been implicated in acute appendicitis, where they have been found by immunohistochemistry (IHC) as epithelial and submucosal infiltrates that correlate positively with severity of disease (Swidsinski and Ismail 2011).…”
Section: Discussionmentioning
confidence: 99%
“…It is common in dental plaque (Bolstad et al 1996;Ximenez-Fyvie et al 2000), and there is a well-established association between F. nucleatum and periodontitis (Signat et al 2011). Anecdotally, F. nucleatum has been found to cause cerebral abscesses (Kai et al 2008) and pericarditis (Han et al 2003), and it is one of the Fusobacterium species responsible for Lemierre's syndrome, a rare form of thrombophlebitis (Weeks et al 2010). More recently, various Fusobacteria including F. nucleatum have been implicated in acute appendicitis, where they have been found by immunohistochemistry (IHC) as epithelial and submucosal infiltrates that correlate positively with severity of disease (Swidsinski and Ismail 2011).…”
Section: Discussionmentioning
confidence: 99%
“…3,8,16,18,[25][26][27][28][29][30] In recent years, anaerobic micro-organisms are being more frequently isolated from brain abscess. The most common anaerobic bacteria are Bacteroides (especially B. fragilis), Fusobacterium and anaerobic streptococci and their usually mixed growth is seen in culture.…”
Section: Discussionmentioning
confidence: 99%
“…However, F. necrophorum tends either to be a minority isolate (56,145) or not to be found at all (244), with F. nucleatum being a much more common isolate. The current literature search identified 9/251 F. necrophorum patients with cerebral abscess, ranging from 5 to 45 years in age and with a median age of 17 (9,109,183,203,204,259,269,313,392). Among the cases with a clear source, two were otogenic (109,204) and four followed throat infections (9,269,392,303).…”
Section: Cerebral Abscessmentioning
confidence: 99%