Fusobacterium bloodstream infections: A literature review and hospital-based case series

Almohaya, Abdulellah M.; Almutairy, Talal Saad; Alqahtani, Abdulah; Binkhamis, Khalifa; Almajid, Fahad

doi:10.1016/j.anaerobe.2020.102165

Cited by 21 publications

(33 citation statements)

References 28 publications

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“…We also noted a high relative abundance of the recently described chicken pathogen Gallibacterium anatis [69] in most birds (with ve birds showing >5% reads assigned to this organism), despite their healthy status. Similarly, Fusobacterium mortiferuman opportunistic pathogen of humans [70]-accounted for >10% of sequences in ten birds, corroborating a recent report of high abundance of 16S sequences from this organism obtained from the chicken caecum [71].…”

Section: Reference-based Pro Ling Documents Novel Diversitysupporting

confidence: 86%

A Genomic Blueprint of the Chicken Gut Microbiome

Gilroy¹,

Ray²,

Getino³

et al. 2020

Preprint

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Background: The chicken is the most abundant food animal in the world. However, despite its importance, the chicken gut microbiome remains largely undefined. Here, we exploit culture-independent and culture-dependent approaches to deliver a genomic blueprint of this complex microbial community. Results: We performed metagenomic sequencing of fifty chicken faecal samples from two breeds and analysed these, alongside all (n=582) relevant publicly available chicken metagenomes, to cluster over 20 million non-redundant genes and to construct over 5,500 metagenome-assembled bacterial genomes. In addition, we recovered nearly 600 bacteriophage genomes This represents the most comprehensive view of the chicken gut associated microbiome to date, encompassing dozens of novel candidate bacterial genera and hundreds of novel candidate species. Keen to provide a stable, clear and memorable nomenclature for novel species, we devised a scalable combinatorial system for the creation of hundreds of well-formed Latin binomials. We cultured bacterial isolates from faeces to deliver 282 whole genome sequences, incorporating thirty novel species, together with three species from the genus Escherichia, including the newly named species Escherichia whittamii.Conclusions: Our metagenomic and culture-based analyses provide new insights into the bacterial, archaeal and bacteriophage components of the chicken gut microbiome. The resulting datasets expand the known diversity of the chicken gut microbiome and provides a key resource for future high-resolution taxonomic and functional studies on the chicken gut microbiome.

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Section: Reference-based Pro Ling Documents Novel Diversitysupporting

confidence: 86%

A Genomic Blueprint of the Chicken Gut Microbiome

Gilroy¹,

Ray²,

Getino³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…We also noted a high relative abundance of the recently described chicken pathogen Gallibacterium anatis [69] in most birds (with ve birds showing >5% reads assigned to this organism), despite their healthy status. Similarly, Fusobacterium mortiferuman opportunistic pathogen of humans [70]-accounted for >10% of sequences in ten birds, corroborating a recent report of high abundance of 16S rRNA gene sequences from this organism obtained from the chicken caecum [71].…”

Section: Reference-based Pro Ling Documents Novel Diversitysupporting

confidence: 86%

A Genomic Census of the Chicken Gut Microbiome using Metagenomics and Culture

Gilroy¹,

Ray²,

Getino³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background. The chicken is the most abundant food animal in the world. However, despite its importance, the chicken gut microbiome remains largely undefined. Here, we exploit culture-independent and culture-dependent approaches to deliver a genomic blueprint of this complex microbial community.Results. We performed metagenomic sequencing of fifty chicken faecal samples from two breeds and analysed these, alongside all (n=582) relevant publicly available chicken metagenomes, to cluster over 20 million non-redundant genes and to construct over 5,500 metagenome-assembled bacterial genomes. In addition, we recovered nearly 600 bacteriophage genomes This represents the most comprehensive view of the chicken gut associated microbiome to date, encompassing dozens of novel candidate bacterial genera and hundreds of novel candidate species. Keen to provide a stable, clear and memorable nomenclature for novel species, we devised a scalable combinatorial system for the creation of hundreds of well-formed Latin binomials. We cultured and genome-sequenced bacterial isolates from faeces, documenting thirty novel species, together with three species from the genus Escherichia, including the newly named species Escherichia whittamii.Conclusions. Our metagenomic and culture-based analyses provide new insights into the bacterial, archaeal and bacteriophage components of the chicken gut microbiome. The resulting datasets expand the known diversity of the chicken gut microbiome and provides a key resource for future high-resolution taxonomic and functional studies on the chicken gut microbiome.

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“…In a hospital-based case series, Almohaya et al highlighted the increase in the numbers of Lemierre syndrome and bacteremia caused by Fusobacterium spp. in Saudi Arabia; during their analysis, the authors found 205 individual cases reported from their country, in addition on the two cases they have presented between 2015 and 2019 [ 95 ]. A study by Stabler et al from France evaluated the relevance of Clostridium spp.…”

Section: Epidemiological Studies On Anaerobic Bacteria In Adultsmentioning

confidence: 99%

Relevance of anaerobic bacteremia in adult patients: A never-ending story?

Gajdács

Urbán

2020

European Journal of Microbiology and Immunology

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Abstract Obligate anaerobic bacteria are considered important constituents of the microbiota of humans; in addition, they are also important etiological agents in some focal or invasive infections and bacteremia with a high level of mortality. Conflicting data have accumulated over the last decades regarding the extent in which these pathogens play an intrinsic role in bloodstream infections. Clinical characteristics of anaerobic bloodstream infections do not differ from bacteremia caused by other pathogens, but due to their longer generation time and rigorous growth requirements, it usually takes longer to establish the etiological diagnosis. The introduction of matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) has represented a technological revolution in microbiological diagnostics, which has allowed for the fast, accurate and reliable identification of anaerobic bacteria at a low sample cost. The purpose of this review article is to summarize the currently available literature data on the prevalence of anaerobic bacteremia in adults for physicians and clinical microbiologists and to shed some light on the complexity of this topic nowadays.

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Fusobacterium bloodstream infections: A literature review and hospital-based case series

Cited by 21 publications

References 28 publications

A Genomic Blueprint of the Chicken Gut Microbiome

A Genomic Blueprint of the Chicken Gut Microbiome

A Genomic Census of the Chicken Gut Microbiome using Metagenomics and Culture

Relevance of anaerobic bacteremia in adult patients: A never-ending story?

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