Fusobacterium necrophorum and other Fusobacterium spp. isolated from head and neck infections: A 10-year epidemiology study in an academic hospital

Yusuf, Erlangga; Halewyck, Stijn; Wybo, Ingrid; Piérard, Denis; Gordts, Frans

doi:10.1016/j.anaerobe.2015.05.006

Cited by 16 publications

(14 citation statements)

References 15 publications

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“…This prompts the hypothesis that oral cavity microbiota, also seen in the guts of IBD patients, may play a significant role in the pathogenesis and progression of IBD. Species of Fusobacterium are also associated with a wide variety of negative health outcomes, such as dental plaque, periodontal disease, Lemierre syndrome [ 44 ], head and neck infections [ 45 ], and especially colon cancer [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease

et al. 2016

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BackgroundGut microbiome dysbiosis has been demonstrated in subjects with newly diagnosed and chronic inflammatory bowel disease (IBD). In this study we sought to explore longitudinal changes in dysbiosis and ascertain associations between dysbiosis and markers of disease activity and treatment outcome.MethodsWe performed a prospective cohort study of 19 treatment-naïve pediatric IBD subjects and 10 healthy controls, measuring fecal calprotectin and assessing the gut microbiome via repeated stool samples. Associations between clinical characteristics and the microbiome were tested using generalized estimating equations. Random forest classification was used to predict ultimate treatment response (presence of mucosal healing at follow-up colonoscopy) or non-response using patients’ pretreatment samples.ResultsPatients with Crohn’s disease had increased markers of inflammation and dysbiosis compared to controls. Patients with ulcerative colitis had even higher inflammation and dysbiosis compared to those with Crohn’s disease. For all cases, the gut microbial dysbiosis index associated significantly with clinical and biological measures of disease severity, but did not associate with treatment response. We found differences in specific gut microbiome genera between cases/controls and responders/non-responders including Akkermansia, Coprococcus, Fusobacterium, Veillonella, Faecalibacterium, and Adlercreutzia. Using pretreatment microbiome data in a weighted random forest classifier, we were able to obtain 76.5 % accuracy for prediction of responder status.ConclusionsPatient dysbiosis improved over time but persisted even among those who responded to treatment and achieved mucosal healing. Although dysbiosis index was not significantly different between responders and non-responders, we found specific genus-level differences. We found that pretreatment microbiome signatures are a promising avenue for prediction of remission and response to treatment.Electronic supplementary materialThe online version of this article (doi:10.1186/s13073-016-0331-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease

et al. 2016

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“…In one case series, the three most common sites for isolation of F. necrophorum and other Fusobacterium sp. were acute tonsillitis, peritonsillar abscess and acute otitis 5…”

Section: Discussionmentioning

confidence: 99%

Fusobacterium necrophorumsepsis after tonsillitis/pharyngitis

2019

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Fusobacterium necrophorum is a rare infection most notable for causing Lemierre’s syndrome. This consists of a primary oropharyngeal infection and septic thrombophlebitis, and one or more metastatic focus. Prior to the widespread use of antibiotics, Lemierre’s syndrome commonly followed a rapidly progressing course, with a high mortality. We describe a case of a previously well 18-month-old boy who presented to the emergency department with a 3-week history of progressive, right-sided, painful neck swelling and systemic sepsis. He was initially treated conservatively with intravenous antibiotics, but ultimately required surgical drainage. Lemierre’s syndrome is a rare condition with increasing incidence which can have significant adverse outcomes including death. Early recognition and treatment are essential, but identifying Lemierre’s disease is challenging.

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“…Fusobacterium species, strictly anaerobic gram‐negative rods, are primarily isolated from the oral cavity, although they can also be found in the abdomen and urogenital tract . The publication of newer studies connecting Fusobacterium species with head and neck infections may be related to increased awareness of the potential devastating effects of this pathogen, with resultant increased testing.…”

Section: Discussionmentioning

confidence: 99%

Implication of Fusobacterium necrophorum in recurrence of peritonsillar abscess

Ali¹,

Kovatch²,

Smith

et al. 2018

The Laryngoscope

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Objective: Peritonsillar abscess (PTA) is a common infectious complication of pharyngeal infection managed by otolaryngologists and emergency room physicians. Streptococcus and Fusobacterium (e.g., Fusobacterium necrophorum, FN) species are commonly isolated pathogens. The aim of this study was to determine the implication of culture results on abscess recurrence following drainage.Methods: Single-institution retrospective review of patients treated at the University of Michigan between 2000 and 2017. Demographic and clinical outcome data were analyzed, including treatment details, culture data, and recurrence.Results: One hundred fifty-six of the 990 patients in our study developed recurrence of their abscess (16%). The age ranges most susceptible to recurrence included adolescent (22.9%) and young adult groups (17.1%). Recurrent patients were more likely to have experienced acute progression of symptoms (79% vs. 71%, P = 0.03), trismus (67% vs. 55%, P = 0.006), voice changes (65% vs. 57%, P = 0.04), and dysphagia (72% vs. 61%, P = 0.01) compared to nonrecurrent patients. They were also more likely to have clinical lymphadenopathy noted on initial examination (67% vs. 56%, P = 0.009). Culture data was sent for 852 patients (86%). The presence of FN was significantly more prevalent in the recurrent group (P < 0.0001).Conclusion: There is a high observed prevalence of FN species within PTA aspirates in the recurrent PTA population. PTA aspirate should be sent for anaerobic growth to screen for Fusobacterium species. In addition, follow-up and lower threshold for subsequent tonsillectomy should be considered in this at-risk group.

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Fusobacterium necrophorum and other Fusobacterium spp. isolated from head and neck infections: A 10-year epidemiology study in an academic hospital

Cited by 16 publications

References 15 publications

Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease

Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease

Fusobacterium necrophorumsepsis after tonsillitis/pharyngitis

Implication of Fusobacterium necrophorum in recurrence of peritonsillar abscess

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