Fusobacterium necrophorum Hepatic Abscess and Colorectal Cancer

Jolobe, Oscar M.P.

doi:10.1016/j.amjmed.2019.09.032

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…[20] It is generally accepted that colon cancer leads to the destruction of intestinal mucosal barrier, and enteric bacteria enter the blood along with the portal vein to cause liver abscess. [21] In addition, the relationship between diabetes and colon cancer is also attracting increasing attention. A large cross-sectional study showed that diabetes mellitus significantly increases the risk of gastrointestinal tumors, especially colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

2023

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Introduction: Klebsiella pneumoniae-induced liver abscess (KP-PLA) is a common type of pyogenic liver abscess, severe acute pancreatitis (SAP) has high mortality, and poor prognosis in advanced colon cancer. There have been no report of SAP complicated with colon cancer after KP-PLA as so far. In this study, we reported a case of SAP secondary to KP-PLA with colon cancer for the first time, so as to provide reference for clinical diagnosis and treatment of these diseases.Patient concerns and diagnosis: A 64-year-old woman with a history of diabetes visited our hospital with abdominal pain for 5 + days. He was diagnosed with KP-PLA a month ago, which had not healed when he was admitted. He was diagnosed with SAP, and histological examination of colonic biopsy confirmed the diagnosis of moderately differentiated adenocarcinoma.Interventions and outcomes: He was treated with intravenous antibiotics and underwent modified endoscopic mucosal resection under colonoscopy. We conducted a 2-month follow-up, and there was no recurrence of liver abscess and pancreatitis. Conclusion:Screening for intestinal tumors is necessary in patients with cryptogenic liver abscess, especially KP-PLA with diabetes.

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Section: Discussionmentioning

confidence: 99%

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

2023

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Identification of linear B cell epitopes on the leukotoxin protein of Fusobacterium necrophorum

Xiao,

Yu,

Jiang

et al. 2024

Anaerobe

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Intersecting Pathologies: Vulvar Cancer Complicated by a Fusobacterium necrophorum Infection

Anderson,

Carletto,

Barreto-Nadal

et al. 2024

Cureus

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Vulvar cancer represents a small minority of annual cancer cases in America. This malignancy affects more than the physical health of the patient. This malignancy also has a negative impact on women’s psychological and sexual health. This case pertains to a 49-year-old woman (G1P1001) who presented with right groin pain, fever, and chills for three days. She reported experiencing vaginal bleeding during the intercourse and had been able to palpate a mass inside her vagina for the past five years. A pelvic exam revealed a 6 cm tender mass on the left vaginal wall, which was friable and hemorrhagic on palpation, along with associated lymphadenopathy. The patient was taken to the operating room where the exophytic mass and lymphadenopathy were biopsied. Necrotic lymph nodes were removed and sent for pathology. Pathology confirmed moderately differentiated squamous cell carcinoma of the vulva. The lymph node pathology report also indicated that the necrotic nodes were infected with Fusobacterium necrophorum . Given the extent of the tumor, it was deemed largely inoperable, and the patient was recommended local radiation therapy. The patient was diagnosed with stage III vulvar cancer. This case highlights the intersection of gynecology-oncology and infectious disease, with a never-before-documented bacterial infection in the context of vulvar cancer. Fusobacterium necrophorum has been previously associated with colorectal cancers, liver abscesses, and ovarian abscesses. Further ingestion is needed to understand the role of this pathogen in the development of vulvar cancer.

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Fusobacterium necrophorum Hepatic Abscess and Colorectal Cancer

Cited by 3 publications

References 4 publications

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

Occult colon cancer with liver abscess and pancreatitis as the first manifestations: A case report

Identification of linear B cell epitopes on the leukotoxin protein of Fusobacterium necrophorum

Intersecting Pathologies: Vulvar Cancer Complicated by a Fusobacterium necrophorum Infection

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