Fusobacterium nucleatum and Colorectal Cancer

Li, Rongrong; Shen, Jilu; Xu, Yuanhong

doi:10.2147/idr.s357922

Cited by 21 publications

(14 citation statements)

References 54 publications

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“…The current studies show that F . nucleatum can actively participate in the occurrence and metastasis of CRC by affecting a variety of mechanisms including, among others, immune regulation [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota profiles in feces and paired tumor and non-tumor tissues from Colorectal Cancer patients. Relationship to the Body Mass Index

Tesolato,

Ortega-Hernández,

Gómez-Garre

et al. 2023

PLoS ONE

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Colorectal Cancer (CRC) and Obesity constitute two of the most common malignancies in the western world, and previously have been associated with intestinal microbial composition alterations. Our main aim in this study is to provide molecular data on intestinal microbiota patterns in subjects with CRC, as well as to establish possible associations with their Body Mass Index (BMI). A total of 113 samples from 45 subjects were collected and submitted to metagenomics analysis for gut microbiota. This study was performed by 16S ribosomal RNA bacterial gene amplification and sequencing using the Ion Torrent™ technology. The same dominant phyla were observed in feces and colorectal tissues, although a greater proportion of Fusobacteriota was found in tumor samples. Moreover, at the genus level, LEfSe analysis allowed us to detect a significant increase in Fusobacterium and Streptococcus in colorectal tissues with respect to fecal samples, with a significant preponderance of Fusobacterium in tumor tissues. Also, our data revealed relevant associations between gut microbiota composition and tumor location. When comparing bacterial profiles between right and left colon cancers, those from the left-sided colon showed a significant preponderance, among others, of the order Staphylococcales. Moreover, phyla Firmicutes and Spirochaetota were more abundant in the group of right-sided CRCs and phylum Proteobacteria was increased in rectal cancers. In relation to BMI of patients, we detected significant differences in beta diversity between the normal weight and the obese groups of cases. Microbiota from obese patients was significantly enriched, among others, in Bacteroidales. Therefore, our results are useful in the molecular characterization of CRC in obese and non-obese patients, with a clear impact on the establishment of diagnostic and prognosis of CRC.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota profiles in feces and paired tumor and non-tumor tissues from Colorectal Cancer patients. Relationship to the Body Mass Index

Tesolato,

Ortega-Hernández,

Gómez-Garre

et al. 2023

PLoS ONE

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“…Interestingly, the lethal effect of natural killer (NK) cells in a tumor microenvironment was inhibited by F . nucleatum , which also exerted a significant inhibitory effect on immune cells, such as T cells derived from HtigiT expressed in human NK cells ( Li, Shen & Xu, 2022 ).…”

Section: Role and Mechanism Of F Nucleatum In The ...mentioning

confidence: 99%

Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort

Gong

Adomako-Bonsu

Wang

et al. 2023

PeerJ

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Colorectal cancer (CRC), which develops from the gradual evolution of tubular adenomas and serrated polyps in the colon and rectum, has a poor prognosis and a high mortality rate. In addition to genetics, lifestyle, and chronic diseases, intestinal integrity and microbiota (which facilitate digestion, metabolism, and immune regulation) could promote CRC development. For example, enterotoxigenic Bacteroides fragilis, genotoxic Escherichia coli (pks+ E. coli), and Fusobacterium nucleatum, members of the intestinal microbiota, are highly correlated in CRC. This review describes the roles and mechanisms of these three bacteria in CRC development. Their interaction during CRC initiation and progression has also been proposed. Our view is that in the precancerous stage of colorectal cancer, ETBF causes inflammation, leading to potential changes in intestinal ecology that may provide the basic conditions for pks+ E. coli colonization and induction of oncogenic mutations, when cancerous intestinal epithelial cells can further recruit F. nucleatum to colonise the lesion site and F. nucleatum may contribute to CRC advancement by primarily the development of cancer cells, stemization, and proliferation, which could create new and tailored preventive, screening and therapeutic interventions. However, there is the most dominant microbiota in each stage of CRC development, not neglecting the possibility that two or even all three bacteria could be engaged at any stage of the disease. The relationship between the associated gut microbiota and CRC development may provide important information for therapeutic strategies to assess the potential use of the associated gut microbiota in CRC studies, antibiotic therapy, and prevention strategies.

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“…Recent studies have shown that F. nucleatum can translocate to and colonize multiple human tissues and organs through a variety of strategies ( 4 , 5 ) and contribute to the development of many systemic diseases, such as atherosclerosis, diabetes mellitus, pregnancy complications, premature delivery, respiratory infectious diseases, and Alzheimer's disease ( 6 – 10 ). Moreover, F. nucleatum plays an important role in the development and metastasis of many cancer types, including head and neck squamous cell carcinoma ( 11 , 12 ), colorectal cancer ( 13 , 14 ), breast cancer, and esophageal cancer ( 15 ), etc. Adhesion is one of the important strategies by which F. nucleatum exerts its pathogenicity toward the host, and among adhesion-related proteins, FadA ( 16 , 17 ), Fap2 ( 18 , 19 ), FomA ( 20 ), and RadD ( 21 , 22 ) have been well-studied, but our knowledge of their association with pathogenicity-related genes and their pathogenesis strategies is still far from sufficient.…”

Section: Introductionmentioning

confidence: 99%

Pangenomic Study of Fusobacterium nucleatum Reveals the Distribution of Pathogenic Genes and Functional Clusters at the Subspecies and Strain Levels

Sun

Zhou

et al. 2023

Microbiol Spectr

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We used F. nucleatum as an example to analyze the genomic characteristics of oral pathogens at the species, subspecies, and strain levels and elucidate the similarities and differences in functional genes and virulence factors among different subspecies/strains of the same oral pathogen. We believe that the unique biological characteristics of each subspecies/strain can be attributed to the differences in functional gene clusters or the presence/absence of certain virulence genes.

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Fusobacterium nucleatum and Colorectal Cancer

Cited by 21 publications

References 54 publications

Gut microbiota profiles in feces and paired tumor and non-tumor tissues from Colorectal Cancer patients. Relationship to the Body Mass Index

Gut microbiota profiles in feces and paired tumor and non-tumor tissues from Colorectal Cancer patients. Relationship to the Body Mass Index

Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort

Pangenomic Study of Fusobacterium nucleatum Reveals the Distribution of Pathogenic Genes and Functional Clusters at the Subspecies and Strain Levels

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