FUT3 and FUT2 genotyping and glycoconjugate profile Lewisb as a protective factor to Toxoplasma gondii infection

Nakashima, Fabiana; Mattos, Cinara Cássia Brandão de; Ferreira, Ana Iara Costa; Spergiorin, Lígia Cosentino Junqueira Franco; Meira-Strejevitch, Cristina da Silva; Oliani, António Hélio; Vaz-Oliani, Denise Cristina Mós; Pereira-Chioccola, Vera Lúcia; Mattos, Luiz Carlos de

doi:10.1016/j.actatropica.2019.02.031

Cited by 7 publications

(5 citation statements)

References 52 publications

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“…Although the frequency of the secretor phenotype varies across populations, approximately 80% of the world population are secretors [ 16 ]. In Brazil, the prevalence of this phenotype revealed in the few studies, is somewhat similar, ranging from 75% to 90% [ 28 , 49 , 50 , 51 ]. The 82% of secretors in the control group found in the present study were therefore consistent with these previous observations.…”

Section: Discussionmentioning

confidence: 99%

FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

Tonini

Barreira

Santolin

et al. 2020

Viruses

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Host susceptibility according to human histo-blood group antigens (HBGAs) is widely known for norovirus infection, but is less described for rotavirus. Due to the variable HBGA polymorphism among populations, we aimed to evaluate the association between HBGA phenotypes (ABH, Lewis and secretor status) and susceptibility to rotavirus and norovirus symptomatic infection, and the polymorphisms of FUT2 and FUT3, of children from southeastern Brazil. Paired fecal-buccal specimens from 272 children with acute diarrhea were used to determine rotavirus/norovirus genotypes and HBGAs phenotypes/genotypes, respectively. Altogether, 100 (36.8%) children were infected with rotavirus and norovirus. The rotavirus P[8] genotype predominates (85.7%). Most of the noroviruses (93.8%) belonged to genogroup II (GII). GII.4 Sydney represented 76% (35/46) amongst five other genotypes. Rotavirus and noroviruses infected predominantly children with secretor status (97% and 98.5%, respectively). However, fewer rotavirus-infected children were Lewis-negative (8.6%) than the norovirus-infected ones (18.5%). FUT3 single nucleotide polymorphisms (SNP) occurred mostly at the T59G > G508A > T202C > C314T positions. Our results reinforce the current knowledge that secretors are more susceptible to infection by both rotavirus and norovirus than non-secretors. The high rate for Lewis negative (17.1%) and the combination of SNPs, beyond the secretor status, may reflect the highly mixed population in Brazil.

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Section: Discussionmentioning

confidence: 99%

FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

Tonini

Barreira

Santolin

et al. 2020

Viruses

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“…In a recent study, researchers assessed the association between T. gondii infection and the Duffy blood group system and found that phenotypes and antigens of this blood group system do not constitute risk factors for infection by T. gondii and the development of ocular toxoplasmosis [ 27 ]. In a study of pregnant women in Brazil, investigators showed that the Lewis b profile appears to protect against T. gondii infection [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Pérez-Álamos,

Aguilar-Durán,

Estrada Martínez

et al. 2024

EuJMI

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We aimed to determine the association between the seropositivity to Toxoplasma gondii and the ABO and Rh blood groups in 2,053 people. ABO and Rhesus blood groups and anti-T. gondii IgG and IgM antibodies were determined using commercially available assays. Of the 2,053 people studied, 171 (8.3%) were positive for anti-T. gondii IgG antibodies. Sixty-five (38.0%) and 36 (21.1%) of these 171 individuals had high anti-T. gondii IgG antibody levels (≥150 IU mL−1) and anti-T. gondii IgM antibodies, respectively. We found the following prevalences of T. gondii infection among the ABO groups: 8.5% in group A, 4.3% in group B, 4.7% in group AB, and 8.9% in group O (P = 0.19). The prevalences of T. gondii infection among Rh groups were: 8.4% in the Rh-positive group and 7.1% in the Rh-negative group (P = 0.58). Logistic regression analysis showed that the frequencies of ABO and Rh blood groups were similar (P > 0.05) among people with positive and negative serology for anti-T. gondii IgG antibodies, with high (≥150 IU mL−1) and lower (<150 IU mL−1) levels of anti-T. gondii IgG antibodies, and with positive and negative serology for anti-T. gondii IgM antibodies. Results does not support an association between T. gondii infection and ABO and Rh blood groups.

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“…However, our analysis showed that the dominant gene model, recessive gene model, codominant gene model, and allele frequency of the rs3894326 and rs28362459 loci were not significantly correlated with IBD. As the data from Nakashima et al [ 11 ] show, the rs28362459 mutation only affects the conformation of the α-1,3/4 fucosyltransferase, relatively reducing the intestinal level of Lewis antigen. This alteration of the α-1,3/4 fucosyltransferase may not affect the intestinal flora distribution enough.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the FUTs and corresponding disorders are deepening. For instance, association between the polymorphism of the FUT3 gene and Toxoplasma gondii infection [11], breast cancer [12], gastric cancer [13], liver cancer [14], and other diseases has been reported. There have been many studies on the association between polymorphism of the FUT2 gene and IBD [15][16][17], but corresponding data have not been studied by meta-analysis yet [18].…”

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confidence: 99%

Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review

Zheng,

Zhu

2023

Asian Biomedicine

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Background Inflammatory bowel disease (IBD) is a condition with an unclear genetic basis. Fucosyltransferase 3 (FUT3) could potentially be linked to IBD susceptibility. Objective To investigate the association between FUT3 gene polymorphisms and IBD. Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 checklist and Population, Intervention, Comparison, Outcomes, and Study (PICOS) guidelines, case-control studies published until April 30, 2020 was searched. Two independent reviewers conducted screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale. Meta-analysis, sensitivity analysis, and Egger tests were performed using RevMan and Stata12.0. Results The review included 5 articles and 12 case-control studies involving 1712 IBD patients and 1903 controls. The meta-analysis revealed the following combined odds ratios [95% confidence intervals]: rs3745635 genotype (GA+AA vs GG) 0.84 (0.72–0.97), (GG+GA vs AA) 1.93 (1.23–3.05), (GG vs AA) 2.38 (1.52–3.74), (A vs G) 0.84 (0.73–0.96); rs3894326 genotype (TA+AA vs TT) 1.03 (0.87–1.23), (TT+TA vs AA) 1.19 (0.56–2.51), (TT vs AA) 1.19 (0.56–2.51), (A vs T) 1.02 (0.86–1.20); rs28362459 genotype (TG+GG vs TT) 0.98 (0.85–1.12), (TT+TG vs GG) 1.20 (0.90–1.61), (TT vs GG) 1.21 (0.90–1.62), (G vs T) 0.96 (0.86–1.07). Sensitivity analysis indicated the stability of the results, and Egger analysis showed no significant publication bias. Conclusions The rs3745635 gene polymorphism may be associated with IBD susceptibility, whereas the rs3894326 and rs28362459 gene polymorphisms may not be associated with IBD.

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FUT3 and FUT2 genotyping and glycoconjugate profile Lewisb as a protective factor to Toxoplasma gondii infection

Cited by 7 publications

References 52 publications

FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

FUT2, Secretor Status and FUT3 Polymorphisms of Children with Acute Diarrhea Infected with Rotavirus and Norovirus in Brazil

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Polymorphism of fucosyltransferase 3 gene is associated with inflammatory bowel disease: a systematic review

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