The paper assesses climate changes in Nišava District, Serbia, focusing on 2001-2020 data from the E-OBS database. Findings show rising maximum and daily temperatures, slightly decreased precipitation, and increased extreme temperatures, and also indicate an increase in summer days, tropical days, and extreme temperatures, emphasizing the need for climate change adaptation. Risks include heatwaves, droughts, urban flooding, water scarcity, reduced agriculture, infrastructure damage, and health threats. Adapting with strategic planning and investments, especially in Niš, is crucial to enhance resilience and readiness for future challenges.