In the 21st century a new technology was introduced to facilitate communication, collaboration, and interaction between individuals and businesses. This technology is called Social Networking; this technology is now part of Internet commodities like email, browsing and blogging. From the 20th century until now the Internet has shaped the way organizations, academics and health sectors to interact, communicate, connect, and exchange knowledge around the world. Social Networking can reduce enterprises cost, increase profit, and assist to develop new communication forms between consumers, stakeholders, vendors, suppliers, universities and health departments. However, this technology can create new challenges for education and its governance and management. Social networking is considered a precursor to the new 3D virtual presence that will gradually supplant the telephone and video conferencing and finally even the face-to-face communication. This article examines these opportunities, challenges, and threats of social networking in organization, education and health care sectors.