Future Diagnostic Agents

Gemmel, Filip; Dumarey, Nicolas; Welling, Mick M.

doi:10.1053/j.semnuclmed.2008.08.005

Cited by 77 publications

(51 citation statements)

References 75 publications

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“…At first, it was proposed as an agent for distinguishing sterile inflammation from bacterial infection. However, since its introduction in 1993, this has never been confirmed (Gemmel et al, 2009). It was shown to be a sensitive and quite specific marker of infection in a large multicentre study coordinated by the International Atomic Energy Agency (Britton et al, 2002), but this high specificity was not found in another paper (Dumarey et al, 2002).…”

Section: Radiolabelled Antibioticsmentioning

confidence: 94%

Leukocyte and bacteria imaging in prosthetic joint infection

Glaudemans

Galli

Pacilio

et al. 2013

eCM

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There has been a significant increase in the number of joint prosthesis replacements worldwide. Although relatively uncommon, complications can occur with the most serious being an infection. Various radiological and nuclear imaging techniques are available to diagnose prosthetic joint infections (PJI). In this review article, we describe the pathophysiology of PJI, the principles of nuclear medicine imaging and the differences between Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET). The value of nuclear medicine techniques for clinical practice is also discussed.Then we provide an overview of the most often used radionuclide imaging techniques that may be helpful in diagnosing prosthetic joint infection: the 67 Ga-citrate, labelled white blood cells in vitro and in vivo (monoclonal antibodies directed against specific targets on the leukocytes), and 18 F-fluorodeoxyglucose ( 18 F-FDG). We describe their working methods, the pitfalls, and the interpretation criteria. Furthermore, we review recent advances in imaging bacteria, a molecular imaging method that holds promises for the detection of occult infections. We conclude proposing two diagnostic flow-charts, based on data in the literature, that could help the clinicians to choose the best nuclear imaging method when they have a patient with suspicion of or with proven PJI.

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Section: Radiolabelled Antibioticsmentioning

confidence: 94%

Leukocyte and bacteria imaging in prosthetic joint infection

Glaudemans

Galli

Pacilio

et al. 2013

eCM

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show abstract

“…Yapılan ön çalışmalarda steril enflamatuvar alanda akümülasyonu kadar bakteride in vitro olarak belirgin tutulduğu gösterilmiştir. Ancak, bu bileşiklerin enfeksiyona özgü görüntülemede değerinin kanıtlanacağı ileri çalışmalar gerekmektedir (20,60).…”

Section: Bakterinini̇n-vivogörüntülenmesiunclassified

Patient and Personnel Radiation Exposure in Sentinel Lymph Node Practice

Eren¹,

Bekiş²

2017

Nts

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“…A variety of radiopharmaceuticals are available for skeletal infection imaging [3] and several new tracer are being evaluated for use in imaging infection [4]. The characteristics of an ideal infection imaging agents are mentioned in Table 1.…”

Section: Nuclear Medicine Techniquesmentioning

confidence: 99%