Future Directions to Limit Surgical Site Infections

Cuomo, Roberto; Nisi, Giuseppe; Brandi, Cesare; Giardino, Francesco Ruben; Grimaldi, Luca

doi:10.1080/08941939.2019.1566420

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…Recent evidence suggests a role of antigenic stimulus that overdue a chronic inflammatory state led by some bacteria such as Staphylococcus and Ralstonia pickettii [ 1 , 48 , 49 , 50 , 51 ]. However, in 2013 Deva et al hypothesized that bacterial contamination that occurred in the time of implant surgery can produce a predominant T-cell response [ 48 , 49 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

The State of the Art about Etiopathogenetic Models on Breast Implant Associated–Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review

Cuomo

2021

JCM

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Background: Breast-implant-associated anaplastic large cell lymphoma is a rare malignancy linked to texturized breast implants. Although many researchers focus on its etiopathogenesis, this topic is affected by a lack of evidence. Materials and Methods: A literature review about BIA-ALCL was made. Results and conclusions: Although the incidence is reported between 1:355–1:30,000, there is great attention to BIA-ALCL. The incidence is uncertain due to many reasons. It may well be lower, due to inclusion in multiple databases as pointed out by the FDA and undiagnosed cases. The role of chronic inflammation, bacterial contamination, and mechanical forces was discussed. Clarification is needed to understand the mechanisms underlying the progression of alterations and mutations for BIA-ALCL; new molecular analysis and pathogenetic models should be investigated.

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Section: Resultsmentioning

confidence: 99%

The State of the Art about Etiopathogenetic Models on Breast Implant Associated–Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review

Cuomo

2021

JCM

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“…Proper wound dressing is mandatory to avoid bleeding and minimize the chance of surgical site infection [44][45][46]. In the postoperative period, the patient could be unable to wear glasses due to the bandage size; this should be disclosed during the preoperative visit.…”

Section: Postoperative Care and Complicationsmentioning

confidence: 99%

Reconstruction of the Nose: Management of Nasal Cutaneous Defects According to Aesthetic Subunit and Defect Size. A Review

et al. 2020

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The nose represents the most common site for the presentation of cutaneous cancer, especially in sun-exposed areas: ala, dorsum, and tip. Even the smallest loss of substance can create aesthetic and psychosocial concerns for patients; therefore, surgeons who perform nasal reconstruction should be strictly confident with the pertinent surgical anatomy in order to tailor the procedure to the patient’s condition and needs. Radical tumor excision and satisfactory aesthetic and functional results are primary targets. Restoring the original shape is the goal of any reconstruction: appropriate reshaping of three-dimensional geometry, proper establishment of symmetry, and excellent color and texture match to the adjacent structures are paramount features. Multiple options exist to re-establish functional and aesthetic integrity after surgical oncology; nevertheless, the management of nasal defects can be often challenging, and the gold standard is yet to be found. The current goal is to highlight some of the more common techniques used to reconstruct cutaneous defects of the nose with a specific focus on decision making based on the aesthetic subunit and defect size. The authors attempt to share common pitfalls and offer practical suggestions that they have found helpful in their clinical experience.

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“…Some experts have suggested that future methods aimed at SSI prediction should be based on biomarkers, as this approach might demonstrate an improved ability to discriminate between patients with and without SSI. 6 Albumin is one biomarker which has been proposed for the prediction of SSI. This small, globular protein is produced in the liver and accounts for 50% of the total serum protein content in healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

“…Firstly, malnutrition impairs wound healing by diminishing fibroblast proliferation and collagen synthesis. 6 Secondly, albumin deficiency is linked to lymphocytopaenia and immune dysfunction. 6 It is not surprising that much of the global literature has reported preoperative hypoalbuminaemia to be associated with an increased risk of SSI.…”

Section: Introductionmentioning

confidence: 99%

“…6 Secondly, albumin deficiency is linked to lymphocytopaenia and immune dysfunction. 6 It is not surprising that much of the global literature has reported preoperative hypoalbuminaemia to be associated with an increased risk of SSI. [9][10][11] Our recent study in South African (SA) surgical patients also identified preoperative hypoalbuminaemia as a risk factor for SSI.…”

Section: Introductionmentioning

confidence: 99%

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A comparison of preoperative hypoalbuminaemia with the NNIS and SENIC risk scores for the prediction of surgical site infection in a South African setting

Naidoo

Madiba

Moodley

2020

The Journal of Medical Laboratory Science and Technology of Sou

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Introduction: Preoperative hypoalbuminaemia is a risk factor for surgical site infection (SSI) in the South African (SA) setting. However, the predictive accuracy of preoperative hypoalbuminaemia has not been tested against established SSI risk stratification models in our setting, which could have important implications for SSI prevention strategies. With reference to SSI in SA settings, the study objective was to compare the overall predictive accuracy of preoperative hypoalbuminaemia with that obtained for the SENIC/NNIS risk scores. Method: This was a sub-analysis of a pre-existing laparotomy patient registry (N = 439). Variables collected as part of the registry included preoperative serum albumin measurements and all parameters of the SENIC/NNIS risk scores. Preoperative hypoalbuminaemia was defined as preoperative serum albumin of < 30 g/L. The study outcome was SSI up to 30 days postoperatively. Overall predictive accuracy was determined through a receiver operator-characteristic (ROC) curve analysis, with results presented as C-statistics (95% confidence intervals [CI]). Results: The C-statistics obtained for preoperative hypoalbuminaemia, the SENIC risk score, and the NNIS risk score were 0.677 (CI: 0.609–0.746), 0.652 (CI: 0.582–0.721), and 0.634 (CI: 0.563–0.705). Conclusion: All three methods display similar predictive accuracy for SSI. However, preoperative hypoalbuminaemia has several practical advantages over the SENIC/NNIS scores which must be considered.

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Future Directions to Limit Surgical Site Infections

Cited by 5 publications

References 13 publications

The State of the Art about Etiopathogenetic Models on Breast Implant Associated–Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review

The State of the Art about Etiopathogenetic Models on Breast Implant Associated–Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review

Reconstruction of the Nose: Management of Nasal Cutaneous Defects According to Aesthetic Subunit and Defect Size. A Review

A comparison of preoperative hypoalbuminaemia with the NNIS and SENIC risk scores for the prediction of surgical site infection in a South African setting

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