In the face of the fourth industrial revolution (Industry 4.0 era), in order to cope with the various crises that may come, countries around the world are accelerating the research and development of cutting-edge technologies and promoting and deploying the Industries of the Future in order to seize the high ground in the new round of strategic competition in science and technology. Therefore, entrepreneurship in Industries of the Future has become an urgent problem for governments and enterprises to solve. Entrepreneurship in Industries of the Future is a systematic project with uncertainties, which is dynamically influenced by many factors and has different levels of division among them. Inspired by the form of Porter’s diamond model, this paper constructs a diamond model of the driving mechanism of entrepreneurship in Industries of the Future. Using the DEMATEL-ISM analysis method, each critical factor and influence mechanism of entrepreneurship in Industries of the Future is explored, and a multi-level structural model is established. The study found eight critical factors affecting entrepreneurship in Industries of the Future, among which technology, creation, need, and aspiration are the critical factors, and relevant enterprises and governments should prioritize these influencing factors and deal with them.