Future of ePix detectors for high repetition rate FELs

Blaj, G.; Caragiulo, P.; Carini, G.; Dragone, A.; Haller, G.; Hart, Philip; Hasi, J.; Herbst, R.; Kenney, C.; Marković, Bojan; Nishimura, K.; Pines, J.; Segal, J.; Tamma, C.; Tomada, A.

doi:10.1063/1.4952884

Cited by 25 publications

(13 citation statements)

References 20 publications

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“…The need for robust hit-finding solutions is of increasing relevance given the current developments at XEFL sources, which focus on higher repetition rate, rather than stronger individual pulses. For example, the AGIPD detector at the European XFEL allows the readout of~3500 patterns/second 36 and similar kHz readout rates of diffraction data are also expected for LCLS-II 37 . Being able to identify shots containing weak diffraction patterns will be crucial in order to be able to fully leverage the properties of these sources for single-particle imaging.…”

Section: Discussionmentioning

confidence: 94%

A statistical approach to detect protein complexes at X-ray free electron laser facilities

et al. 2018

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The Flash X-ray Imaging (FXI) technique, under development at X-ray free electron lasers (XFEL), aims to achieve structure determination based on diffraction from individual macromolecular complexes. We report an FXI study on the first protein complex-RNA polymerase II-ever injected at an XFEL. A successful 3D reconstruction requires a high number of observations of the sample in various orientations. The measured diffraction signal for many shots can be comparable to background. Here we present a robust and highly sensitive hit-identification method based on automated modeling of beamline background through photon statistics. It can operate at controlled false positive hit-rate of 3 × 10 −5. We demonstrate its power in determining particle hits and validate our findings against an independent hit-identification approach based on ion time-of-flight spectra. We also validate the advantages of our method over simpler hit-identification schemes via tests on other samples and using computer simulations, showing a doubled hit-identification power.

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Section: Discussionmentioning

confidence: 94%

A statistical approach to detect protein complexes at X-ray free electron laser facilities

et al. 2018

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“…There are other special X-ray imagers such as ePix100 24 , Pilatus 25 , Eiger 26 and pnCCD 4 . Some of them may simultaneously possess both position sensitivity and spectroscopy properties.…”

Section: Discussionmentioning

confidence: 99%

Seeing elements by visible-light digital camera

Zhao

Sakurai

2017

Sci Rep

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A visible-light digital camera is used for taking ordinary photos, but with new operational procedures it can measure the photon energy in the X-ray wavelength region and therefore see chemical elements. This report describes how one can observe X-rays by means of such an ordinary camera - The front cover of the camera is replaced by an opaque X-ray window to block visible light and to allow X-rays to pass; the camera takes many snap shots (called single-photon-counting mode) to record every photon event individually; an integrated-filtering method is newly proposed to correctly retrieve the energy of photons from raw camera images. Finally, the retrieved X-ray energy-dispersive spectra show fine energy resolution and great accuracy in energy calibration, and therefore the visible-light digital camera can be applied to routine X-ray fluorescence measurement to analyze the element composition in unknown samples. In addition, the visible-light digital camera is promising in that it could serve as a position sensitive X-ray energy detector. It may become able to measure the element map or chemical diffusion in a multi-element system if it is fabricated with external X-ray optic devices. Owing to the camera’s low expense and fine pixel size, the present method will be widely applied to the analysis of chemical elements as well as imaging.

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“…The camera and data acquisition system can record full frames of over 540 kpixel at rates in excess of 120 Hz [4]. The system supports Region of Interest (ROI) readout and can reach frame rates of over 1 kHz in this mode.…”

Section: Electronic Designmentioning

confidence: 99%