Many measurements are necessary in the program of studying mixing, CP violation and rare decays of b and c quarks. These measurements require large numbers of B o , Bs, B − and D * + hadrons. Fortunately, copius production of particles containing b and c quarks will occur at Tevatron and the LHC. The crucial measurements are described here, as well as the design of the two experiments, LHC-b and BTeV, that can exploit the 4 − 20 × 10 11 b hadrons produced every 10 7 seconds.