Future Perspectives of Radionanomedicine Using the Novel Micelle-Encapsulation Method for Surface Modification

Lee, Yun Sang; Kim, Yong Il; Lee, Dong Hoon

doi:10.1007/s13139-015-0358-9

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…Nanomaterials can provide multifunctional platforms for radiolabeling which enables simultaneous imaging and therapy against the multiplexed targets for proper personalized combined internal radiotherapy. Using the recent one-step surface modification for nanomaterials to have multiple functions, nanomaterials can simultaneously possess multiple targeting ligands and multiple radioisotopes labeled for diagnostic and therapeutic purposes (7,41). The multifunctionality and flexibility of radiolabeled nanomaterials will promote the radionuclide theranostics.…”

Section: Y and 177mentioning

confidence: 99%

“…Although more than 200 nanomedicine products have been in clinical trials or even approved (2), eventual success in clinical therapeutics is still uncertain. A feasible breakthrough for future clinical application of nanomaterials may come from radionanomedicine, an approach for clinical translation using radiolabeled nanomaterials (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

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Translational radionanomedicine: a clinical perspective

Choi¹,

Lee²,

Hwang³

et al. 2016

European Journal of Nanomedicine

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Many nanomaterials were developed for the anticipated in vivo theranostic use exploiting their unique characteristics as a multifunctional platform. Nevertheless, only a few nanomaterials are under investigation for human use, most of which have not entered clinical trials yet. Radionanomedicine, a convergent discipline of radiotracer technology and use of nanomaterials in vivo, can facilitate clinical nanomedicine because of its advantages of radionuclide imaging and internal radiation therapy. In this review, we focuse on how radionanomedicine would impact profoundly on clinical translation of nanomaterial theranostics. Up-to-date advances and future challenges are critically reviewed regarding the issues of how to radiolabel and engineer radionanomaterials, in vivo behavior tracing of radionanomaterials and then the desired clinical radiation dosimetry. Radiolabeled extracellular vesicles were further discussed as endogenous nanomaterials radiolabeled for possible clinical use.

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Section: Y and 177mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Translational radionanomedicine: a clinical perspective

Choi¹,

Lee²,

Hwang³

et al. 2016

European Journal of Nanomedicine

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“…In case of radiolabeled nanoparticles, physical or chemical core labeling was reported, but capsular labeling or surface modifications were considered more practical [61][62][63][64][65][66]. Surface modifications could be done either by chemical or physical methods; however, the physical method using a micelle-encapsulation method tended to prevail as it removed cumbersome sequential steps of separation and reaction [61,67]. In case of monoclonal antibodies, obviously the chelator linker-based methods are the solution [68,69].…”

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confidence: 99%

Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics

Suh

Lee

2018

Nucl Med Mol Imaging

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Brain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of endophenotype classification, blood-brain barrier (BBB), target determination, ignorance of biodistribution after administration, and complex intercellular communication between brain cells, make brain theranostics application difficult, especially when it comes to clinical application. So, a more thorough understanding of each aspect is needed. In this review, we focus on recent studies regarding the role of exosomes in intercellular communication of brain cells, therapeutic effect of graphene quantum dots, transcriptomics/epitranscriptomics approach for target selection, and in vitro/in vivo considerations.

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Halide‐Modulated Functionality of Wide Band Gap Zinc Oxide Semiconductor Nanoparticle

et al. 2018

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Surface modification of inorganic nanomaterials using different ions is well-known to induce significant modulation in functionality of the nanoparticles (NP), which improves tuning their relevant properties for suitable applications in the field of nanotechnology. Here, we report synthesis and surface modification of a model inorganic wide bandgap semiconductor ZnO NP by halide ions by simple precipitation method and demonstrate that proximity of various halide ions to the NP modifies their electronic properties. It is interesting to note that such surface modulation has little impact on its morphology, while significantly influencing their applications in photocatalytic activity or magnetism. Indeed, the halide attached ZnO NP displays a large reduction of defect state emission. Various microscopic and spectroscopic tools (including picosecond resolved technique) were used to characterize and understand the key role of the halide ions to modulate the light induced charge separation in ZnO NP. Picosecond resolved fluorescence spectra unveil a significant quenching, implying an electronic cross-talking between the NP and the attached halide ions. Magnetic measurements indicate that attachment of a suitable halide ion introduces room temperature ferromagnetism in this system. Finally, the photocatalytic activity of the ZnO NP for the photodegradation of a model pollutant, methyl orange was evaluated under UV light irradiation. Halide ZnO is anticipated to be a very promising photocatalytic agent; hence it can be used to cleanup environmental pollution. First principles analysis has been performed to understand the modulation of electronic properties like photocatalysis and magnetism in halide attached nanosystem. The experimental behavior resembles nicely with theoretical results.[a] T.

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Future Perspectives of Radionanomedicine Using the Novel Micelle-Encapsulation Method for Surface Modification

Cited by 9 publications

References 31 publications

Translational radionanomedicine: a clinical perspective

Translational radionanomedicine: a clinical perspective

Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics

Halide‐Modulated Functionality of Wide Band Gap Zinc Oxide Semiconductor Nanoparticle

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