Future Prevention and Treatment of Radiation-Induced Hyposalivation

Coppes, Robert P.; Water, Tara A. van de

doi:10.1007/978-3-642-55154-3_13

Cited by 2 publications

(2 citation statements)

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“…Most of these treatments stimulate the proliferation of the remaining SSPCs, limiting their use to (parts of) the tissue that have received a relatively low dose [46]. These approaches encompass both pharmacological agents that stimulate the parasympathetic response of the gland, such as pilocarpine, and growth factors that stimulate proliferation [46]. The saliva secretion inducing sialagogue, Pilocarpine, has been relatively well studied, both as a treatment before and after radiotherapy.…”

Section: Therapeutic Approachesmentioning

confidence: 99%

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Prevention and treatment of radiotherapy‐induced side effects

2020

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Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of patients. The precision with which the radiation dose can be delivered is rapidly improving. This precision allows the more accurate targeting of radiation dose to the tumor and reduces the amount of surrounding normal tissue exposed. Although this often reduces the unwanted side effects of radiotherapy, we still need to further improve patients' quality of life and to escalate radiation doses to tumors when necessary. Highprecision radiotherapy forces one to choose which organ or functional organ substructures should be spared. To be able to make such choices, we urgently need to better understand the molecular and physiological mechanisms of normal tissue responses to radiotherapy. Currently, oversimplified approaches using constraints on mean doses, and irradiated volumes of normal tissues are used to plan treatments with minimized risk of radiation side effects. In this review, we discuss the responses of three different normal tissues to radiotherapy: the salivary glands, cardiopulmonary system, and brain. We show that although they may share very similar local cellular processes, they respond very differently through organ-specific, nonlocal mechanisms. We also discuss how a better knowledge of these mechanisms can be used to treat or to prevent the effects of radiotherapy on normal tissue and to optimize radiotherapy delivery.

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Section: Therapeutic Approachesmentioning

confidence: 99%

“…number of surviving SSPCs and their effect might be limited to the lower radiation dose regions [46]. Interestingly, MSCs have been shown to remodel radiationinduced fibrosis [52].…”

Section: Therapeutic Approachesmentioning

confidence: 99%