In the domain of Nuclear reactions at intermediate energies, the QCD coupling constant α s is large enough (∼ 0.3 -0.5) to render the perturbative calculational techniques inapplicable. In this regime the quarks are confined into colorless hadrons and it is expected that effective field theories of hadron interactions via exchange of hadrons, provide useful tools to describe such reactions. In this contribution we discuss the application of one such theory, the effective Lagrangian model, in describing the hadronic reactions at intermediate energies whose measurements are the focus of a vast international experimental program.In the quest for understanding the quantum chromodynamics (QCD), the hadron-hadron, hadron-photon and hadron-lepton reactions have played a major role. From these studies two quite distinct regimes of QCD have emerged. The first regime is of those processes that involve very high momentum transfers. Here the asymptotic freedom property of QCD has enabled the perturbative QCD (pQCD) methods to describe [1] a large set of high energy large momentum transfer reaction observables with great precision, providing the most precise test of QCD to date [2,3].The second regime that includes nuclear reactions at intermediate energies, is characterized by the confinement of quarks inside the hadrons. This remarkable feature, along with the running of the QCD coupling constant (α s ) towards larger values makes the pQCD methods inapplicable -one requires techniques that can solve the theory exactly. To date, the only fully predictive non-perturbative method for studying QCD at low energies is 201 , 02002 (2016) EPJ Web of Conferences