Future research directions to characterize environmental mutagens in highly polluted area

Srám, R J

doi:10.1289/ehp.96104s3603

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…We can mention problems with mutual variations in outcomes of similar studies, insufficient power of accessible retrospective records on individual environmental exposures, lack of biomarkers reflecting stages of the carcinogenic process or problems with sufficiently long time series of observation [15,16]. Origin of analyzed data, precision and validity of measurements are therefore very important attributes to be followed in these studies.…”

Section: Cancer Epidemiology As Endpoint In Risk Studiesmentioning

confidence: 99%

Conceptual Model Enhancing Accessibility of Data from Cancer–Related Environmental Risk Assessment Studies

Dušek¹,

Hřebíček²,

Kubásek³

et al. 2011

IFIP Advances in Information and Communication Technology

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Abstract. This paper proposes conceptual model which can be used to facilitate the discovery, integration and analysis of environmental data in cancer-related risk studies. Persistent organic pollutants were chosen as a model because of their persistence, bioaccumulation potential and genotoxicity. Part dealing with cancer risk is primarily focused on population-based observations encompassing a wide range of epidemiologic studies, from local investigations to national cancer registries. The proposed model adopted multilayer hierarchy working with characteristics of given entities (POPs, cancer diseases as nomenclature classes) and couples "observation -measurement" as content defining classes. The proposal extends formally used taxonomy applying multidimensional set of descriptors including scores of measurement validity and precision. This solution has the potential to aid multidisciplinary data discovery and knowledge mining. The same structure of descriptors used for environmental and cancer part enables the users to integrate different data sources recognizing their methodical origin, time & space coordinates and validity.Keywords: Persistent organic pollutants, cancer risk, data model, data discovery. Introducing Problems with Data Accessibility"Data rich -information poor" is becoming obligatory phrase or accepted "professional dialect" associated with environmental monitoring. It also extends to the cancer risk assessment which has recently attracted increasing attention. Most problems can be explained by the heterogeneity of input data ranging from laboratory bio-tests to multilevel epidemiologic observations. Progress increasingly requires standardized access to multi-disciplinary information resources, including chemical, geological, meteorological, epidemiologic and demographic data. Each broadly ranged ecological or human risk study must adopt both following scenarios [1,2]: 462 L. Dušek et al.1. retrospective exploitation of data sources and their description in discovery process 2. prospective arrangement enabling effective electronic data capture in future From the viewpoint of informatics, environmental risk assessment can be characterized as processing of heterogeneous data leading to probabilistic estimation of some uncertain (prospective approach) or on the other hand relatively certain (retrospective approach) risk event. Main complications that hamper progress in this field are highlighted in the following list:1. Extremely wide range of data types and structures in environmental studies 2. Insufficient metadata description and standardization 3. Lack of well established repositories based on standardized protocols which is in strong contrast to methodical progress in environmental and medical sciences 4. Variability of technologies, coding and reporting systems used by different research groups 5. Growing number of small and not adequately published and described studies, which however produce valuable and important data.Especially last point deserves special attention. Growing number of s...

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Section: Cancer Epidemiology As Endpoint In Risk Studiesmentioning

confidence: 99%

Conceptual Model Enhancing Accessibility of Data from Cancer–Related Environmental Risk Assessment Studies

Dušek¹,

Hřebíček²,

Kubásek³

et al. 2011

IFIP Advances in Information and Communication Technology

View full text Add to dashboard Cite

show abstract

Eastern-Urals radioactive trace as a source of genetic diversity in rodents populations at adjacent territories

Grigorkina,

Rakitin,

Olenev

2024

Radiation biology. Radioecology

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Firstly, polymorphism of gene cytochrome b’(cytb) fragment of mitochondrial DNA (mtDNA ) and migratory activity of red-backed voles (Myodes rutilus Pallas, 1779) at zone of local radioactive pollution – Eastern-Urals radioactive trace zone (EURT) are investigated. More high haplotype diversity in both samples from EURT zone and adjacent background territory (9–10 km) as compared with the reference one (220 kms) was found. Moreover nucleotide diversity and average number of pair distinctions between haplotypes were greatest in voles from contiguous site with background radiation level. Our hypothesis about association genetic diversity with rodents’ migrations from EURT zone were verified in field experiments employing group marking of population by biomarker rhodamine B. Migrants (males and females) of different functional status at background sites were revealed. Long-distance movements (9500 m) are maximal known for M. rutilus. EURT zone is a source of genetic diversity in rodents populations on adjacent territories due to interpopulation gene flows patterns (radiation-induced effects) carrying by migrants. MtDNA can be served as an effective biomarker of radionuclide exposure in natural environment. Сombining usage of ecological and molecular biomarkers is expediently for monitoring in rodents inhabiting zones of local radionuclides pollution.

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Future research directions to characterize environmental mutagens in highly polluted area

Cited by 2 publications

References 16 publications

Conceptual Model Enhancing Accessibility of Data from Cancer–Related Environmental Risk Assessment Studies

Conceptual Model Enhancing Accessibility of Data from Cancer–Related Environmental Risk Assessment Studies

Eastern-Urals radioactive trace as a source of genetic diversity in rodents populations at adjacent territories

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