Future therapies targeted towards eliminating<i>Candida</i>biofilms and associated infections

Bandara, Nihal; Matsubara, Victor Haruo; Samaranayake, LP

doi:10.1080/14787210.2017.1268530

Cited by 25 publications

(16 citation statements)

References 247 publications

(83 reference statements)

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“…Interestingly, we observed that E. coli and S. enterica growing rate was superior after the toothbrush immersion in Listerine. The only exception was observed against C. albicans, wich had a lower growing rate after the immersion; this last result is similar to the observations reported in 2016 in a literature review that referred to Listerine as a superior chemical agent along with CHX in Candida biofilm elimination [19].…”

Section: Discussionsupporting

confidence: 89%

An in Vitro Effectiveness Evaluation of Chemical Agents for Toothbrushes Disinfection

Merchán

Merino-Alado

Briceño

et al. 2019

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate in the vitro effectiveness of three chemical agents for toothbrush disinfection. Material and Methods: Sixteen new toothbrushes were evaluated, previously sterilized and classified in five experimental groups (n=3) and one item as control. Three chemical agents were assessed: 0.12% Chlorhexidine gluconate (CHX), essential oil mouth rinse (Listerine) and 3.5% Sodium hypochlorite (NaOCl). The five selected strains were inoculated on toothbrushes and incubated for a 24 hours period and 37°C temperature in aerobic conditions. The incubated toothbrushes were immersed for a 15 min period into selected chemical agents and after drying in a controlled air stream, again re-cultured into enriched broth. A comparison was made between the initial and final microorganisms density recovered after chemical disinfection based on Mc Farland scale. The data obtained was compared by descriptive analysis and ANOVA methodology. Results: 3.5% NaOCl was the most effective chemical agent for toothbrush disinfection followed by CHX; Listerine was not effective to eliminate the inoculated bacteria in toothbrushes. Conclusion: 3.5% NaOCl and 0.12% CHX are the most effective chemical agents for toothbrush disinfection and Listerine was only effective against C. albicans.

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Section: Discussionsupporting

confidence: 89%

An in Vitro Effectiveness Evaluation of Chemical Agents for Toothbrushes Disinfection

Merchán

Merino-Alado

Briceño

et al. 2019

Pesqui. bras. odontopediatria clín. integr.

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“…In the last years, novel vaginal drug delivery formulations have focused attention to treat fungal infections. Candida species are the fourth leading agent of health care associated infections worldwide with the highest mortality rate of all nosocomial bloodstream infections, even exceeding those caused by Staphylococcus aureus and Pseudomonas aeruginosa (Bandara, Matsubara, & Samaranayake, 2017).…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations

Moreno

Gómez‐Mascaraque

Arias

et al. 2018

Carbohydrate Polymers

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The design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with proved biological properties (Larrea divaricata, L. cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) were developed through electrospraying and compared with conventionally used tablets containing the same extracts. Total phenolics, loading efficacy, physical properties, morphology and particle size, molecular organization, water sorption capacity, release of bioactive compounds and biological properties were assessed. The encapsulation process or the inclusion in tablets did not degrade the bioactive compounds of the extracts. The release of phenolic compounds from chitosan microcapsules was faster than from tablets. The fingerprint of released phenolic compounds from microcapsules and tablets was similar to that from the dry extracts and the antioxidant and antifungal capacity remained unchanged. The FT-IR analysis suggested interactions between the chitosan and the extracts, which explained why the microcapsules kept the integrity in slightly acidic media. Increased solubility of the extracts when incorporated in the microcapsules was seen in simulated vaginal fluid, potentially increasing the bioavailability of bioactive compounds in the vaginal environment. This work highlights the potential of the chitosan-based delivery systems for phytomedicines with antifungal and antioxidant activity to be used in vulvovaginal candidiasis.

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“…Furthermore, in vivo intervention studies with L. reuteri (DSM 17938 and ATCC PTA 5289) administered in food or as lozenges reduced Candida presence and load (Hatakka et al, 2007;Kraft-Bodi et al, 2015), increased unstimulated whole saliva in the elderly (Hatakka et al, 2007), and reduced the gingival index in various patient groups (Krasse et al, 2006;Schlagenhauf et al, 2016;Vivekananda, Vandana, & Bhat, 2010). Two recent papers review the potential of probiotic therapy as anti-Candida therapy and as non-conventional treatment of OLP (Bandara, Matsubara, & Samaranayake, 2017;Han, Zhang, Tan, & Zhou, 2017). In line with this, it was our aim to investigate whether L. reuteri (DSM 17938 and ATCC PTA 5289) could reduce the recurrence of OC in patients with OLP and even the need of symptomatic treatment of OLP-related symptoms.…”

Section: Introductionmentioning

confidence: 99%

Randomized pilot study on probiotic effects on recurrent candidiasis in oral lichen planus patients

Keller

Kragelund

2018

Oral Diseases

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Future therapies targeted towards eliminatingCandidabiofilms and associated infections

Cited by 25 publications

References 247 publications

An in Vitro Effectiveness Evaluation of Chemical Agents for Toothbrushes Disinfection

An in Vitro Effectiveness Evaluation of Chemical Agents for Toothbrushes Disinfection

Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations

Randomized pilot study on probiotic effects on recurrent candidiasis in oral lichen planus patients

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