Future thinking in Parkinson's disease: An executive function?

Vito, Stefania De; Gamboz, Nadia; Brandimonte, Maria A.; Barone, Paolo; Amboni, Marianna; Sala, Sergio Della

doi:10.1016/j.neuropsychologia.2012.03.001

Cited by 119 publications

(93 citation statements)

References 42 publications

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“…The increased cognitive demand would tax above all executive functions because EFT requires the extraction and recombination of an infinite assortment of details into a novel event, whereas AM consists in the recapitulation of a more limited pool of details [6]. This notion is in accord with De Vito et al's [19] study, showing impaired EFT performance with preserved AM scores in Parkinson disease patients, who present with a characteristic dysexecutive syndrome. De Vito et al's aim was to assess EFT performance in patients, who, besides their dysexecutive condition, were nonamnesic and therefore, different from our autobiographical amnesic MS patients.…”

Section: Discussionmentioning

confidence: 77%

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Impaired mental simulation of specific past and future personal events in non-depressed multiple sclerosis patients

Ernst

Blanc

Seze

et al. 2014

Journal of the Neurological Sciences

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The aims of the present study were (i) to explore autobiographical memory and episodic future thought in multiple sclerosis (MS), using Levine's Autobiographical Interview; (ii) to investigate the influence of the Interview's high retrieval support condition (the specific probe phase) on MS patients' past and future simulations and (iii) to obtain the patients' estimations of their own difficulties, during the test, and in everyday life. To that end, we examined 39 non-depressed relapsing-remitting MS patients and 34 healthy subjects matched for gender, age and education level. The 73 participants underwent an adapted version of the Autobiographical Interview in two conditions: remembering and imagining personal events. The group of patients also underwent an extended neuropsychological baseline, including particularly, anterograde memory and executive functions. The results showed that the MS patients' scores on the baseline were mildly or not impaired. On the contrary, the Autobiographical Interview measure, i.e., the mean number of internal details, for each of the two phases of the test -free recall and specific probe -was significantly lower in simulated past and future events in comparison with the healthy controls. Within each group, autobiographical memory performance was superior to episodic future thought performance. A strong positive correlation was observed between past and future mental simulation scores in both groups.In conclusion, our results showed, for the first time, the co-occurrence of deficit of remembering the past and imagining the future in MS patients. They also showed more difficulty in imagining future events than remembering past events for both patients and normal controls. MS being a neurological condition very frequent in the young adult population, the clinical considerations of our study might be of interest. Indeed, they give rise to new insights on MS patients' daily life difficulties related to impaired mental simulation of personal events despite general abilities, including anterograde memory, only mildly or not impaired.

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Section: Discussionmentioning

confidence: 77%

“…[3,19,22]). Moreover, as the AI includes both a free recall and a high retrieval support condition (i.e.…”

Section: Introductionmentioning

confidence: 99%

Impaired mental simulation of specific past and future personal events in non-depressed multiple sclerosis patients

Ernst

Blanc

Seze

et al. 2014

Journal of the Neurological Sciences

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“…We have already highlighted the important role that extracting details from episodic memory plays in the context of episodic simulation. However, other cognitive processes, such as causal reasoning (83), manipulating extracted episodic details through executive resources (84), and scene construction (85), have also been proposed to feature prominently in the context of episodic simulation (additional discussion in ref. 12).…”

Section: Caveatsmentioning

confidence: 99%

A taxonomy of prospection: Introducing an organizational framework for future-oriented cognition

Szpunar

Spreng

Schacter

2014

Proc. Natl. Acad. Sci. U.S.A.

430

324

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Prospection-the ability to represent what might happen in the future-is a broad concept that has been used to characterize a wide variety of future-oriented cognitions, including affective forecasting, prospective memory, temporal discounting, episodic simulation, and autobiographical planning. In this article, we propose a taxonomy of prospection to initiate the important and necessary process of teasing apart the various forms of future thinking that constitute the landscape of prospective cognition. The organizational framework that we propose delineates episodic and semantic forms of four modes of future thinking: simulation, prediction, intention, and planning. We show how this framework can be used to draw attention to the ways in which various modes of future thinking interact with one another, generate new questions about prospective cognition, and illuminate our understanding of disorders of future thinking. We conclude by considering basic cognitive processes that give rise to prospective cognitions, cognitive operations and emotional/motivational states relevant to future-oriented cognition, and the possible role of procedural or motor systems in future-oriented behavior.prospection | simulation | prediction | intention | planning

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“…Several behavioral studies showed a higher number of episodic details provided for past than for future events in healthy subjects (Addis et al 2008; D'Argembeau and Van der Linden 2004), as well as in clinical conditions (D'Argembeau et al 2008;Addis et al 2009). Moreover, in two further clinical conditions, Parkinson's disease (De Vito et al 2012) and patients with thalamic lesion (Weiler et al 2011), EFT impairment was demonstrated, in the context of relatively preserved AM abilities.…”

mentioning

confidence: 92%

Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients

Ernst

Noblet

Denkova

et al. 2015

Brain Imaging and Behavior

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Mental time travel (MTT) entails the ability to mentally travel into autobiographical memory (AM) and episodic future thinking (EFT). While AM and EFT share common phenomenological and cerebral functional properties, distinctive characteristics have been documented in healthy and clinical populations. No report, to our knowledge, has informed on the functional underpinnings of MTT impairment in multiple sclerosis (MS) patients, hence the aim of this work. We studied 22 relapsing-remitting MS patients and 22 matched controls. Participants underwent an AM/EFT assessment using the Autobiographical Interview (Levine et al. 2002), followed by a functional MRI session. The latter consisted in AM and EFT tasks, distinguishing the construction and elaboration phases of events. The results showed impaired performance for AM and EFT in patients, accompanied by increased cerebral activations mostly located in the frontal regions, which extended to the parietal, lateral temporal and posterior regions during AM/EFT tasks, relative to healthy controls. Enhanced brain activations in MS patients were particularly evident during the EFT task and involved the hippocampus, frontal, external temporal, and cingulate regions. The construction phase required greater fronto-parieto-temporal activations in MS patients relative to both healthy controls, and the elaboration phase. Taking together, our results suggested the occurrence of cerebral activation changes in the context of MTT in MS patients, expressed by distinct and common mechanisms for AM and EFT. This study may provide new insights in terms of cerebral activation changes in brain lesion and their application to clinical settings, considering AM/EFT's central role in everyday life.

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Future thinking in Parkinson's disease: An executive function?

Cited by 119 publications

References 42 publications

Impaired mental simulation of specific past and future personal events in non-depressed multiple sclerosis patients

Impaired mental simulation of specific past and future personal events in non-depressed multiple sclerosis patients

A taxonomy of prospection: Introducing an organizational framework for future-oriented cognition

Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients

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