Fuxin decoction attenuates doxorubicin-induced heart failure in rats via oxidizing suppression and regulating immune responses

Guo, Yuhong; Di, Tingting; Zhao, Juan; Xu, Xiaolong; Li, Ping; Huang, Lijuan; Lian, Qingquan

doi:10.1016/s0254-6272(18)30890-2

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…To prepare the heart failure model, doxorubicin (saline preparation, 2 mg/mL) was administered intraperitoneally to the remaining rats at a dose of 1.5 mL/kg, once a week for 7 weeks. A combined dose of 21 mg/kg was used to establish the model, in accordance with the literature ( Yuhong et al, 2018 ). After 7 weeks of administration, rats in the treatment group were gavaged with Sanwei sandalwood decoction at a dose of 2 g/kg for 30 consecutive days, while rats in the blank and model groups were given an equivalent volume of saline ( Zhou, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

Sanwei sandalwood decoction improves function of the gut microbiota in heart failure

Ma,

Bai,

et al. 2023

Front. Microbiol.

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ObjectiveTo investigate the effects of Sanwei sandalwood decoction on improving function of the intestinal flora in doxorubicin-induced heart failure in rats.Materials and methodsThirty Sprague–Dawley rats were screened and randomly assigned into a blank group, a model group, and a Sanwei sandalwood decoction group (treatment group). The rat model of heart failure was prepared and established in the latter two groups. After successful model establishment, the treatment group received Sanwei sandalwood decoction by continuous gavage at 2 g/kg, once daily for 4 weeks. The other groups were given an equivalent volume of saline. After the final dose, fecal samples were collected from each group and analyzed by macrogenomics and nontargeted metabolomics to characterize the intestinal flora and associated metabolites.ResultsThe composition of gut microbiota was significantly different between the three groups. There were 778,808 common genes between the blank and model groups, while 49,315 genes were lost and 521,008 were gained in the model group relative to the blank group. At the phylum level, all groups of rat fecal samples were dominated by Firmicutes, Bacteroidota, Actinobacteria, and Proteobacteria. At the genus level, the microbial community composition in all experimental groups of rat fecal samples was dominated by Lactobacillus, Bifidobacterium, Limosilactobacillus, Allobaculum, Prevotella, and Ligilactobacillus spp. Interestingly, cluster analysis was performed on the top 30 KEGG ontology (KO) terms displaying significant differences in relative abundance in the rat fecal microbiome among experimental groups. The relative frequency of posttranslational modification, coenzyme transport and metabolism, cell wall, membrane, and envelope biogenesis in the eggNOG and CAZy databases. In the nontargeted metabolomics, the group principal component analysis revealed that the groups were well distinguished from one another. The different metabolites were screened with VIP >1, and the KEGG different metabolite classification and enrichment analysis revealed that there includes 15 metabolites pathway, including loxoprofen, conifery-l-acetate, trichilin A, and others. The arachidonic acid pathway also accounted for a significant portion of the KEGG pathway classification analysis.ConclusionSanwei sandalwood decoction positively affects the intestinal microbial environment of rats with heart failure, improving the gut dysbiosis that is caused by the condition. This treatment intervention inhibits the growth of pathogenic bacteria and promotes the growth of beneficial species.

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Section: Methodsmentioning

confidence: 99%

Sanwei sandalwood decoction improves function of the gut microbiota in heart failure

Ma,

Bai,

et al. 2023

Front. Microbiol.

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“…HF is the end stage of various cardiac diseases, such as valvular heart disease, coronary artery disease, and hypertension, which primarily have myocardial damage in common as pathogenesis. In developed countries, the prevalence of HF is approximately 1%-2% in the adult population, while it is ≥10% among people above 70 years of age [ 1 ]. Due to the rapidly aging global population, the worldwide prevalence of HF is expected to continuously increase [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Identification and Comparison of Potential Biomarkers by Proteomic Analysis in Traditional Chinese Medicine-Based Heart Failure Syndromes

Yang

Zhao

Huang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Heart failure (HF) is an epidemic disease affecting a large population worldwide. Traditional Chinese medicine (TCM) is playing an increasingly important role in the clinical treatment of HF. According to the TCM theory, HF could be classified into Yang deficiency and Qi-yin deficiency; however, there are few objective and biological lines of evidence for differentiation of TCM HF syndromes to date. In this study, data-independent acquisition (DIA) mass spectrometry was applied to comparatively analyze the protein expression in serum samples obtained from 12 Yang deficiency patients, 12 Qi-yin deficiency patients, and 12 healthy volunteers. Compared to the healthy controls, a total of 121 differentially expressed proteins (DEPs) (77 upregulated and 44 downregulated proteins) were identified in Yang deficiency samples, while 59 DEPs (49 upregulated and 10 downregulated proteins) were detected in Qi-yin deficiency samples. Enrichment analyses of these DEPs based on the GO and KEGG databases revealed functional clusters associated with the immune system, signal transduction, and infectious disease. Several previously reported HF biomarker proteins were found to be the hub proteins in a protein-protein interaction network analysis. Three novel hub DEPs were identified as potential biomarkers for differentiation between different TCM syndromes of HF. The results provide biological insight into the differences of different TCM HF syndromes and an opportunity for specific biomarker identification for different TCM HF syndromes.

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Four-week intravenous repeated dose toxicity study of vitacamphorae injection in rats

Yuan

Liu

et al. 2020

Naunyn-Schmiedeberg's Arch Pharmacol

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Fuxin decoction attenuates doxorubicin-induced heart failure in rats via oxidizing suppression and regulating immune responses

Cited by 6 publications

References 13 publications

Sanwei sandalwood decoction improves function of the gut microbiota in heart failure

Sanwei sandalwood decoction improves function of the gut microbiota in heart failure

Identification and Comparison of Potential Biomarkers by Proteomic Analysis in Traditional Chinese Medicine-Based Heart Failure Syndromes

Four-week intravenous repeated dose toxicity study of vitacamphorae injection in rats

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