Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

Liu, Dongmin; Wang, Siyu; Liu, Yaqing; Luo, Yong; Wen, Beibei; Wu, Wenliang; Zeng, Hongliang; Huang, Jianan; Liu, Zhonghua

doi:10.1039/d3fo01782f

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…A study elucidated that FBT markedly reduced the lipid levels in hyperlipidemia zebrafish (Xiao et al ., 2023). Similarly, FBT had a good improvement effect on high‐fat obese mice (Zhu et al ., 2023; Liu et al ., 2023b). Furthermore, the predominant fungus of FBT also displayed the benefit of resisting fat granule accumulation in the liver (Song et al ., 2023).…”

Section: Introductionmentioning

confidence: 99%

Unravelling the hypoglycemic mechanism of Fuzhuan brick tea: insights into intestinal microbiota and metabolites in type 2 diabetes mellitus mice

Liu,

Xiang,

Zeng

et al. 2024

Int J of Food Sci Tech

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SummaryFuzhuan brick tea (FBT), a post‐fermented tea, has been demonstrated to have an antidiabetic effect. However, evidence of its hypoglycemic effect via gut microbiota and intestinal metabolites has been limited. This work aimed to reveal the potential mechanism of FBT against type 2 diabetes mellitus (T2DM) mice by regulating gut flora and short‐chain fatty acids (SCFAs). Thus, we established a T2DM mice model induced by streptozotocin and a high‐fat diet, and the 16S rDNA gene sequencing analysed gut microbiota changes, while GC/MS detected SCFAs levels in colonic contents. As a result, after being treated with FBT, the biochemical index of mice revealed significant improvement and the levels of colonic SCFAs were enhanced. Through correlation analysis, the key gut microbiota for the hypoglycemic effect of FBT were identified including Cyanobacteria, Alloprevotella, Erysipelatoclostridium, etc. Additionally, the antidiabetic actions of FBT were mediated by the SCFAs‐GPR41/43‐GLP‐1 pathway and alleviating inflammation related to the increased gut barrier with the tight junction proteins (Claudin‐1, Occludin and ZO‐1). To sum up, our study provides insights into the possible mechanism of FBT in T2DM and might promote the application of FBT as a potential hypoglycemic agent in the future.

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Section: Introductionmentioning

confidence: 99%

Unravelling the hypoglycemic mechanism of Fuzhuan brick tea: insights into intestinal microbiota and metabolites in type 2 diabetes mellitus mice

Liu,

Xiang,

Zeng

et al. 2024

Int J of Food Sci Tech

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Multi-omics insights into anti-colitis benefits of the synbiotic and postbiotic derived from wheat bran arabinoxylan and Limosilactobacillus reuteri

Zhou,

Song,

Liu

et al. 2024

International Journal of Biological Macromolecules

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Fu brick tea polysaccharides: A state-of-the-art mini-review on extraction, purification, characteristics, bioactivities and applications

Liu,

Wu,

Zhang

et al. 2024

International Journal of Biological Macromolecules

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Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese mice

Abstract: High-fat diet (HFD) induced obesity and its associated conditions, such as hepatic steatosis and steatohepatitis, are major health concerns worldwide. Previous studies have reported the excellent efficiency of Fuzhuan brick...

Cited by 4 publications

References 62 publications

Unravelling the hypoglycemic mechanism of Fuzhuan brick tea: insights into intestinal microbiota and metabolites in type 2 diabetes mellitus mice

Unravelling the hypoglycemic mechanism of Fuzhuan brick tea: insights into intestinal microbiota and metabolites in type 2 diabetes mellitus mice

Multi-omics insights into anti-colitis benefits of the synbiotic and postbiotic derived from wheat bran arabinoxylan and Limosilactobacillus reuteri

Fu brick tea polysaccharides: A state-of-the-art mini-review on extraction, purification, characteristics, bioactivities and applications

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