The guest editors have accepted 41 papers with the special issue. By diagnosis, prognostics and system health management we mean a set of activities including: fault detection, fault classification, fault prognosis, and system modeling. Informally, fault detection refers to the real-time signal processing required to know whether or not a given system is in its healthy normal operating state. Fault classification refers to determination of the type of fault an unhealthy system is suffering from and is a pattern recognition task. Fault prognosis refers to the forecast of the remaining useful life of a system and is based on dynamic modeling. In general, these activities require a sequence of operations such as data acquisition and conditioning, feature extraction, feature selection, and a final