To solve the drawbacks of existing picture enhancement methods which include the error that occur in the pixel intensity expression, a fuzzy inference-centered contextual-dissimilarity histogram equalization (FICDHE) approach is suggested. Proposed system has three components. The first module generates intensity membership functions based on predicted intensity intervals. Second, fuzzy inference techniques are constructed and contextualdissimilarity of every pixel is determined. In the last module, dissimilarity histograms are cut and leveled. The fuzzy system in this study not only addresses the uncertainty source of pixel gray level expression, but is also adaptable. In this approach, the fuzzy inference system membership function parameter is automatically selected depending on picture pixel gray. Its versatility creates an algorithm that is more accessible. Two typical medical photos from BrainWeb are used in experiments. Performance of the suggested technique was compared against a number of enhancement algorithms based on subjective evaluation and picture quality measurement indexes. Experiments show that the proposed method is superior to the other algorithms in terms of improving the contrast improvement index (CII) (03.603), the peak signal-to-noise ratio (PSNR) (22.877), the entropy (E) (06.781), the enhancement measures (EME and EMEE) (56.688 and 3344.63 respectively), the quality index based on local variance (QILV) (00.965), and the feature similarity index (FSIM Index) (00.905).