Fyrsta meðferð með tocilizumab við COVID-19 hérlendis – sjúkratilfelli

Björnsson, Aron Hjalti; Olafsdottir, Thorbjorg; Þormar, Katrín; Kristjánsson, Már; Þórisdóttir, Anna Sesselja; Lúðvíksson, Björn Rúnar; Guðmundsson, Sigurður; Gottfreðsson, Magnús

doi:10.17992/lbl.2020.05.581

Cited by 3 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Тяжесть заболевания, особенно поражение легких, и исход были связаны с тяжестью цитокинового шторма. В результате тоцилизумаб, блокатор рецепторов ИЛ-6, был предложен в качестве возможного варианта лечения [5].…”

Section: Discussionunclassified

Effect of tocilizumab on pulmonary gas exchange function in patients with severe COVID-19

Lebedev,

Dolya,

Savkov

et al. 2023

Transplantologiâ (Mosk.)

View full text Add to dashboard Cite

Introduction. COVID-19 causes cytokine storm and acute respiratory distress syndrome, which can lead to severe lung damage and multiple organ dysfunction. Early use of monoclonal antibodies has shown promising results in cytokine storm therapy, but the effects on lung gas exchange function have not yet been studied.Aim. To evaluate the effect of tocilizumab on the dynamics of gas exchange parameters in patients with severe COVID-19. Material and methods. The study included 26 patients in whom gas exchange parameters (PaO2, PaCO2, P/f ratio), blood oxygen saturation (saturation), respiration rate, duration and parameters of high-flow oxygen therapy and noninvasive mechanical ventilation, length of stay in intensive care unit and total hospital length of stay were assessed.Results. Tocilizumab significantly improved oxygenation on the third day (p=0.001) from the time of drug administration.Conclusion. In the presented and analyzed cohort of patients with severe COVID-19 and cytokine storm, the normalization and significant increase of oxygenation parameters (PaO2, p=0.001; P/f ratio, p=0.001) were observed within three days after a single-dose tocilizumab administration in a complex intensive therapy. No significant dynamics in the respiratory support parameters was revealed, nor an effect of this therapy on the duration of the respiratory support or the reduction in the aggressiveness of its parameters was observed within three days after tocilizumab administration (p>0.05).

show abstract

Section: Discussionunclassified

Effect of tocilizumab on pulmonary gas exchange function in patients with severe COVID-19

Lebedev,

Dolya,

Savkov

et al. 2023

Transplantologiâ (Mosk.)

View full text Add to dashboard Cite

show abstract

“…This finding further suggests that more COVID-19 cases during the Fall wave were detected in returning travelers from summer holidays. A man in Iceland was diagnosed with COVID-19 after vacationing abroad [48]. A genomics study in Australia reported that importations by returned international travelers accounted for over half of locally acquired cases [49].…”

Section: Plos Onementioning

confidence: 99%

The COVID-19 wave in Belgium during the Fall of 2020 and its association with higher education

et al. 2022

View full text Add to dashboard Cite

Soon after SARS-CoV-2 emerged in late 2019, Belgium was confronted with a first COVID-19 wave in March-April 2020. SARS-CoV-2 circulation declined in the summer months (late May to early July 2020). Following a successfully trumped late July-August peak, COVID-19 incidence fell slightly, to then enter two successive phases of rapid incline: in the first half of September, and then again in October 2020. The first of these coincided with the peak period of returning summer travelers; the second one coincided with the start of higher education’s academic year. The largest observed COVID-19 incidence occurred in the period 16–31 October, particularly in the Walloon Region, the southern, French-speaking part of Belgium. We examine the potential association of the higher education population with spatio-temporal spread of COVID-19, using Bayesian spatial Poisson models for confirmed test cases, accounting for socio-demographic heterogeneity in the population. We find a significant association between the number of COVID-19 cases in the age groups 18–29 years and 30–39 years and the size of the higher education student population at the municipality level. These results can be useful towards COVID-19 mitigation strategies, particularly in areas where virus transmission from higher education students into the broader community could exacerbate morbidity and mortality of COVID-19 among populations with prevalent underlying conditions associated with more severe outcomes following infection.

show abstract