G-308A TNF-α polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: Case-control study

Effects of E‐cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular carcinoma

“…Epidemiological studies indicate that both environmental and genetic factors mediate an individual's susceptibility to cancer; i.e., inherited mutations or alterations in certain genes could make individuals more or less susceptible to developing certain cancers. Several single-nucleotide polymorphisms (SNPs), such as stromal cell-derived factor-1 and tumor necrosis factor-alpha (TNF-a) G-308A, are predictive factors related to a higher risk of HCC [6,7]. The identification of genetic factors related to HCC susceptibility may help elucidate the complex process of hepatocarcinogenesis and improve the scientific basis for preventative intervention.…”

Meta-Analysis Shows Strong Positive Association of the TNF-α Gene with Tumor Stage in Bladder Cancer

“…Therefore, we performed this meta-analysis to get a reliable assessment on this association. Although genotype changes at position –308 of the TNF- α promoter are frequently observed in several cancers [18,19,20], in the subgroup analysis according to the source of controls and ethnicity, no significantly statistical evidence was found for healthy and benign control among Asian and Caucasian subjects in various statistical models for the association between –308 G/A polymorphism and bladder cancer risk. The results of this meta-analysis were consistent with the meta-analysis results of some types of cancer [21], but inconsistent with other meta-analyses [22].…”

Genetic Factors, Viral Infection, Other Factors and Liver Cancer: An Update on Current Progress

“…Protective effect of -863 C allele was observed among Thai population, however, -308 was found to be non-significantly related with cancer risk (Kummee et al, 2007). In contrast, a study performed among Turkish population (Akkiz et al 2009) reported a positive association between -308 polymorphism and risk of developing HCC in the Turkish population, to be precise, the OR for the mutation was 4.75 (95%CI=2.25-9.82). Currently, the association between HCC susceptibility and polymorphisms of TNFalpha still remains inconsistent.…”