G-CSF as new treatment option in patients with recurrent implantation failure

Knieper, C.; Franz, Clemens M.; Hirv, K.; Meri, O.; Santjohanser, Claudia; Würfel, W.; Tóth, Bettina

doi:10.1016/j.jri.2011.06.091

Cited by 3 publications

(1 citation statement)

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“…Furthermore, G-CSF participates in ovulation mechanisms (Makinoda et al, 2008), enhances cyclic adenosine monophosphate-mediated decidualization of human endometrial stromal cells and trophoblast invasion into the maternal tissue (Litwin et al, 2005;Tanaka et al, 2000), and is predictive of IVF outcome. Outcomes of repetitive implantation failure can also be improved by G-CSF (Knieper et al, 2011;Wurfel et al, 2010) and decrease the incidence of recurrent spontaneous abortions (Santjohanser et al, 2013;Scarpellini and Sbracia, 2009).…”

Section: Introductionmentioning

confidence: 99%

Two protocols to treat thin endometrium with granulocyte colony-stimulating factor during frozen embryo transfer cycles

Zhang

HAO

et al. 2015

Reproductive BioMedicine Online

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The efficacy of two granulocyte colony-stimulating factor (G-CSF) protocols for thin endometrium were investigated. Eighty-two patients were diagnosed with thin endometrium (<7 mm). Thirty patients with previously cancelled embryo transfers received intrauterine G-CSF in subsequent frozen embryo transfer (FET) cycles. Patients were divided into the G-CSF only and G-CSF with endometrial scratch subgroups. Compared with previous cycles, endometrial thickness increased from 5.7 ± 0.7 mm to 8.1 ± 2.1 mm after G-CSF treatment (P < 0.001). Endometrial thickness increases were not significantly different between the two subgroups. The G-CSF with endometrial scratch subgroup established nominally higher though non-significant clinical pregnancy and live birth rates than the G-CSF only subgroup (53.8 % versus 42.9% and 38.5% versus 28.6%, respectively). Fifty-two patients underwent FET despite edometrial thickness less than 7 mm, and were included as controls. Significantly higher embryo implantation and clinical pregnancy rates were observed in the G-CSF group compared with the control group (31.5% versus 13.9%; P < 0.01; 48.1% versus 25.0%; P = 0.038, respectively). Endometrial scracth did not impair G-CSF treatment for thin endometrium and favoured pregnancy and live birth rates. For patients with thin endometrium, embryo transfer cancellation and G-CSF treatment in subsequent FET cycles is beneficial.

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