G-CSF-Induced Mobilization of Bone Marrow Stem Cells and Cardiac Repair

Dawn, Buddhadeb; Sanganalmath, Santosh K.; Bolli, Roberto

doi:10.1007/978-3-0348-0218-5_24

Cited by 2 publications

(4 citation statements)

References 115 publications

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“…As different mobilizing agents may release bone marrow stem cells with different phenotypic characteristics and biological behaviors, G-CSF was also used in conjunction with other mobilizing agents, for example, stem cell factor (SCF), with the primary goal of enhancing stem cell mobilization [(49), for review see (21)]. Consistent with the known synergism with colony-stimulating factors, administration of G-CSF and SCF highly increased by 250-fold the number of circulating pluripotent hematopoietic stem cells (10).…”

Section: G-csf As Stand-alone and Adjunctive Therapy: Implications Fomentioning

confidence: 99%

“…Consistent with the known synergism with colony-stimulating factors, administration of G-CSF and SCF highly increased by 250-fold the number of circulating pluripotent hematopoietic stem cells (10). Indeed, some studies found that such combination therapy reduced mortality, infarct size, and improved left ventricular function, accompanied by increased homing of bone marrow cells to the infarcted myocardium and formation of new cardiomyocytes and ventricular structures (21). In chronic stroke studies, G-CSF + SCF induced more stable and long-lasting functional improvement compared with treatment with SCF or G-CSF alone, attributable to increased angiogenesis and neurogenesis through bone marrow-derived cells and the direct effects on stimulating neurons to form new neuronal networks (126).…”

Section: G-csf As Stand-alone and Adjunctive Therapy: Implications Fomentioning

confidence: 99%

“…Combining G-CSF with other agents has also been pursued, for example, hematopoietic growth factors (erythropoietin) (21), pharmacotherapies (e.g., simvastatin) (37), amniotic membrane wrappings (31), and others in experimental models of stroke, SCI, and AMI. A majority of these studies reported enhanced effects of combination therapy, or synergism, when compared with treatment with either drug alone.…”

Section: G-csf As Stand-alone and Adjunctive Therapy: Implications Fomentioning

confidence: 99%

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G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

et al. 2015

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Traumatic brain injury (TBI), a major contributor to deaths and permanent disability worldwide, has been recently described as a progressive cell death process rather than an acute event. TBI pathophysiology is complicated and can be distinguished by the initial primary injury and the subsequent secondary injury that ensues days after the trauma. Therapeutic opportunities for TBI remain very limited with patients subjected to surgery or rehabilitation therapy. The efficacy of stem cell-based interventions, as well as neuroprotective agents in other neurological disorders of which pathologies overlap with TBI, indicates their potential as alternative TBI treatments. Furthermore, their therapeutic limitations may be augmented when combination therapy is pursued instead of using a single agent. Indeed, we demonstrated remarkable combined efficacy of human umbilical cord blood (hUCB) cell therapy and granulocyte-colony-stimulating factor (G-CSF) treatment in TBI models, providing essential evidence for the translation of this approach to treat TBI. Further studies are warranted to determine the mechanisms underlying therapeutic benefits exerted by hUCB + G-CSF in order to enhance its safety and efficacy in the clinic.

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Section: G-csf As Stand-alone and Adjunctive Therapy: Implications Fomentioning

confidence: 99%

Section: G-csf As Stand-alone and Adjunctive Therapy: Implications Fomentioning

confidence: 99%

Section: G-csf As Stand-alone and Adjunctive Therapy: Implications Fomentioning

confidence: 99%

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G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

et al. 2015

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“…(7) To reach the efficient regeneration of damaged myocardium, therapeutic treatments have been developed by transplantation of a large number of stem cells into the bloodstream or infarcted heart or enhanced mobilization of stem cells from bone marrow by treatments with cytokines, such as G-CSF. (8;9) However, insufficient stem cell engraftment and survival during these treatments have limited the application of stem cell therapy for treating MI. (10;11) Therefore, a better understanding of the underlying mechanisms regulating stem cell function during cardiac repair may lead to develop novel approaches for stem cell therapies.…”

Section: Introductionmentioning

confidence: 99%

Plasminogen Regulates Cardiac Repair After Myocardial Infarction Through its Noncanonical Function in Stem Cell Homing to the Infarcted Heart

Gong

Zhao

Liu

et al. 2014

Journal of the American College of Cardiology

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Objective The purpose of this study was to investigate the role of Plasminogen (Plg) in stem cell-mediated cardiac repair and regeneration after myocardial infarction (MI) Background MI induces irreversible tissue damage, eventually leading to heart failure. Bone marrow (BM)-derived stem cells promote tissue repair and regeneration after MI. Thrombolytic treatment with Plg activators significantly improves the clinical outcome in MI by restoring cardiac perfusion. However, the role of Plg in stem cell-mediated cardiac repair remains unclear. Methods MI was induced in Plg deficient (Plg−/−) and wild-type (Plg+/+) mice by ligation of left anterior descending coronary artery (LAD). Stem cells were visualized by in vivo tracking of GFP-expressing BM cells after BM transplantation. Cardiac function, stem cell homing, signaling pathways downstream of Plg were examined. Results G-CSF, a stem cell mobilizer, significantly promoted BM-derived stem cells (GFP+c-kit+ cells) recruitment into infarcted heart and stem cell-meidated cardiac repair in Plg+/+ mice. However, Plg deficiency markedly inhibited stem cell homing and cardiac repair, suggesting that Plg is critical for stem cell-mediated cardiac repair. Moreover, Plg regulated CXCR4 expression in stem cells in vivo and in vitro through MMP-9. Lentiviral reconstitution of CXCR4 expression in BM cells rescued stem cell homing to the infarcted heart in Plg-deficient mice, indicating that a critical role of CXCR4 in Plg-mediated stem cell homing after MI. Conclusions These findings have identified a novel role of Plg in stem cell-mediated cardiac repair after MI. Thus, targeting Plg may offer a new therapeutic strategy for stem cell-mediated cardiac repair after MI.

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G-CSF-Induced Mobilization of Bone Marrow Stem Cells and Cardiac Repair

Cited by 2 publications

References 115 publications

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury

Plasminogen Regulates Cardiac Repair After Myocardial Infarction Through its Noncanonical Function in Stem Cell Homing to the Infarcted Heart

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