G-CSF reduces IFN-γ and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function

Nawa, Yuichiro; Teshima, Takanori; Sunami, Kazutaka; Hiramatsu, Yasushi; Maeda, Yoshinobu; Yano, Tomonori; Shinagawa, Katsuji; Ishimaru, Fumihiko; Omoto, Eijiro; Harada, Mine

doi:10.1038/sj.bmt.1702402

Cited by 48 publications

(40 citation statements)

References 30 publications

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“…Experimental murine studies demonstrate that G-CSF polarizes donor T cells toward a type 2 cytokine response. 15 Recently, we have measured the concentration of several cytokines in the serum of patients after allogeneic hematopoietic stem cell transplantation, including soluble interleukin-2 receptor (sIL-2R), IL-6, IL-8 and tumor necrosis factor-a (TNF-a). Results showed that sIL-2R levels increased during aGVHD and that the increase of sIL-2R levels in serum preceded the clinical signs of aGVHD.…”

Section: Discussionmentioning

confidence: 99%

Cytokine expression during acute graft-versus-host disease after allogeneic peripheral stem cell transplantation

Xiao

et al. 2005

Bone Marrow Transplant

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Section: Discussionmentioning

confidence: 99%

Cytokine expression during acute graft-versus-host disease after allogeneic peripheral stem cell transplantation

Xiao

et al. 2005

Bone Marrow Transplant

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“…One non-G-CSF-treated patient died before engraftment because of invasive fungal infection. The median time to reach neutrophil engraftment (40.5 Â 10 9 /l) was 14 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) days in G-CSF-treated patients and 17 days in untreated ones (Po0.001). No significant effect was found on the day of platelet engraftment between the two groups, 18 (10-200) days vs 20 (10-89) days, respectively.…”

Section: Haematological Recovery and Transfusionsmentioning

confidence: 99%

“…[11][12][13][14][15][16] G-CSF also polarises T cells to produce type-2 cytokines, which may be associated with reduced severity of acute GVHD. [17][18][19][20] We carried out a retrospective trial to evaluate the effect of G-CSF on GVHD and other parameters in patients undergoing HSCT with HLA-identical sibling donors.…”

mentioning

confidence: 99%

G-CSF given after haematopoietic stem cell transplantation using HLA-identical sibling donors is associated to a higher incidence of acute GVHD II–IV

Remberger

Naseh

Aschan

et al. 2003

Bone Marrow Transplant

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Summary:The effect of granulocyte colony-stimulating factor (G-CSF), given after transplantation, was studied in 155 patients transplanted with haematopoietic stem cells (HSCT) from HLA-identical sibling donors at Huddinge University Hospital between 1993 and 2001. Only patients with haematological malignancies were included. Conditioning consisted of total-body irradiation in 118 and busulphan in 37 patients. They were all given methotrexate combined with cyclosporine as graft-versus-host disease (GVHD) prophylaxis. Of the 155 patients, 66 (43%) received G-CSF after HSCT. Those given G-CSF had a significantly shorter time to neutrophil engraftment (Po0.001). G-CSF treatment had no effect on erythrocyte transfusions, platelet engraftment and infections. However, patients treated with G-CSF had a significantly higher incidence of grades II-IV acute GVHD than those not given this treatment (34 vs 9%, Po0.001). The multivariate analysis showed that the effect of G-CSF was independent of other known risk factors for grades II-IV acute GVHD. Death from GVHD occurred in four and two cases (P ¼ 0.06) in the two groups, respectively. The cumulative incidences of transplant-related mortality, survival, chronic GVHD, relapse and relapse-free survival were similar in both groups. In conclusion, G-CSF given after HLA-identical sibling HSCT was associated with a higher risk of grades II-IV acute GVHD, but not transplant-related mortality.

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“…6,7 In vitro human studies have demonstrated that PBSC products have high levels of T cell inhibitory activity. [8][9][10][11][12][13] This effect has been variously attributed to the high levels of IL-10 produced by monocytes, 14 to modulation of monocyte function, 15 and more recently, to a mobilisation-associated increase in certain dendritic cell (DC) subsets. 16,17 DC constitute a system of antigen-presenting cells that play a critical role in regulating immune responses.…”

mentioning

confidence: 99%

Differential effects of G-CSF mobilisation on dendritic cell subsets in normal allogeneic donors and patients undergoing autologous transplantation

Hock

Haring

Ebbett

et al. 2002

Bone Marrow Transplant

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Summary:It has been suggested that the immunological properties of cytokine primed PBSC may reflect the presence of altered levels of cellular components. In this study the changes induced in blood dendritic cell (DC) subsets following G-CSF mobilisation are analysed. Analysis of normal donors (n = 64) demonstrated considerable individual variation in the absolute numbers (؋10 6 /l) of resting blood CD11c ؊ DC (1.2-26.2) and CD11c + DC (0.9-34.7) as well as in the CD11c ؊ /CD11c + DC ratio (0.29-4.13). G-CSF therapy increased CD11c ؊ DC numbers to above the normal range in all normal donors analysed (n = 6) and the CD11c ؊ /CD11c + ratio was also increased to Ͼ2.0 in all donors. Patients undergoing autologous PBSCT showed a heterogeneous response to mobilisation and although total DC and CD11c ؊ DC numbers were increased in the majority (8/14), they remained within the normal range post mobilisation. The CD11c ؊ /CD11c + ratio decreased in 5/15 patients and only three patients had ratios Ͼ2.0 post mobilisation. Post G-CSF the DC from all normal donors and 13/14 patients had an immature phenotype. These results demonstrate that G-CSF mobilisation induces relatively consistent changes in the number and ratio of DC subsets in normal donors, but considerable variation is seen in the response of patients undergoing mobilisation for autologous PBSCT.

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G-CSF reduces IFN-γ and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function

Cited by 48 publications

References 30 publications

Cytokine expression during acute graft-versus-host disease after allogeneic peripheral stem cell transplantation

Cytokine expression during acute graft-versus-host disease after allogeneic peripheral stem cell transplantation

G-CSF given after haematopoietic stem cell transplantation using HLA-identical sibling donors is associated to a higher incidence of acute GVHD II–IV

Differential effects of G-CSF mobilisation on dendritic cell subsets in normal allogeneic donors and patients undergoing autologous transplantation

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