G×E Interaction Influences Trajectories of Hand Grip Strength

Petersen, Inge; Pedersen, Nancy L.; Rantanen, Taina; Kremen, William S.; Johnson, Wendy; Panizzon, Matthew S.; Christiansen, Lene; Franz, Carol E.; Christensen, Kaare; Hamdi, Nayla R.; Krueger, Robert F.; Reynolds, Chandra A.

doi:10.1007/s10519-015-9736-4

Cited by 14 publications

(10 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, reports from the IGEMS consortium using a within-pair MZ twin design report small-to-moderate G × E effects across country and gender for cross-sectional measures of BMI, depressive symptoms, cognitive performance 52 as well as grip strength. 53 Furthermore, APOE may partly account for G × E effects for depressive symptoms and spatial reasoning whereby ɛ4 individuals may show less sensitivity to the environment. 52 …”

Section: Discussionmentioning

confidence: 99%

Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins

Karlsson

Escott‐Price

Gatz

et al. 2022

Brain Communications

Self Cite

View full text Add to dashboard Cite

Heritability of Alzheimer’s disease estimated from twin studies is greater than heritability derived from genome-based studies, for reasons that remain unclear. We apply both approaches to the same twin sample, considering both Alzheimer’s disease polygenic risk scores (PRSs) and heritability from twin models, to provide insight into the role of measured genetic variants, and to quantify uncaptured genetic risk. A population-based heritability and polygenic association study of Alzheimer’s disease was conducted between 1986 and 2016 and is the first study to incorporate PRSs into biometrical twin models of Alzheimer’s disease. The sample included 1586 twins drawn from the Swedish Twin Registry which were nested within 1137 twin pairs (449 complete pairs, 688 incomplete pairs) with clinically-based diagnoses and registry follow-up (Mage = 85.28, SD = 7.02; 44% male; 431 cases, 1155 controls). We report contributions of PRSs at P < 1 × 10−05, considering a full PRS, PRS without the APOE region (PRS.no.APOE), and PRS.no.APOE plus directly measured APOE alleles. Biometric twin models estimated the contribution of environmental influences and measured (PRS) and unmeasured genes to Alzheimer’s disease risk. The full PRS and PRS.no.APOE contributed 10.1% and 2.4% to Alzheimer’s disease risk, respectively. When APOE ε4 alleles were added to the model with the PRS.no.APOE, the total contribution was 11.4% to Alzheimer’s disease risk, where APOE ε4 explained 9.3% and PRS.no.APOE dropped from 2.4% to 2.1%. The total genetic contribution to Alzheimer’s disease risk, measured and unmeasured, was 71% while environmental influences unique to each twin accounted for 29% of the risk. The APOE region explains much of the measurable genetic contribution to Alzheimer’s disease, with smaller contributions from other measured polygenic influences. Importantly, substantial background genetic influences remain to be understood.

show abstract

Section: Discussionmentioning

confidence: 99%

Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins

Karlsson

Escott‐Price

Gatz

et al. 2022

Brain Communications

Self Cite

View full text Add to dashboard Cite

show abstract

“…Methods using MZ within-pair differences allow us to test for the presence of GE without having a specific measured early environment. With a MZ within-pair approach, we established evidence of gene × environment for BMI, depressive symptoms, a physical illness index, several cognitive domains (Reynolds et al, 2016) and longitudinal grip strength trajectories (Petersen et al, 2016). Results also suggested that the apolipoprotein E gene (APOE) may act as a 'variability gene' for symptoms of depression and spatial reasoning, but not for other cognitive measures or BMI, with greater intrapair differences for non-ε4 carriers.…”

Section: Approachesmentioning

confidence: 97%

IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies — An Update

et al. 2019

Self Cite

View full text Add to dashboard Cite

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene–environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14–103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.

show abstract

“…As a complex phenotype, hand grip strength is likely influenced by multiple genetic and environmental factors [ 11 ]. The heritability of hand grip strength is estimated to be 56% [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China

Liu

et al. 2021

J Orthop Surg Res

View full text Add to dashboard Cite

Background Hand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in Gongcheng, southern China. Methods APOE rs405509 polymorphisms in 1724 participants (695 men and 1029 women, aged 45–97 years old) were genotyped using the Sequenom MassARRAY platform. Statistical analysis was conducted using SPSS 21.0 and Plink 1.90. Results The APOE rs405509 G allele was associated with lower hand grip strength in all participants (β = −1.04, P value <0.001), and the correlation seemed to be even stronger among women. A significant gene-environment interaction was observed between APOE rs405509 and smoking, especially in men. The hand grip strength of male smokers carrying the GG genotype was significantly higher than that of nonsmokers (P value = 0.004). Conclusions APOE rs405509 polymorphisms might be genetic factors that affect hand grip strength in a rural population in Gongcheng, southern China. The APOE rs405509-smoking interaction has an impact on hand grip strength.

show abstract

G×E Interaction Influences Trajectories of Hand Grip Strength

Cited by 14 publications

References 51 publications

Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins

Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins

IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies — An Update

Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China

Contact Info

Product

Resources

About