G protein-coupled receptor for diapause hormone, an inducer of Bombyx embryonic diapause

Homma, Takashi; Watanabe, Ken; Tsurumaru, Shuichiro; Kataoka, Hiroshi; Imai, Kunio; Kamba, Mari; Niimi, Teruyuki; Yamashita, Okitsugu; Yaginuma, Toshinobu

doi:10.1016/j.bbrc.2006.03.085

Cited by 127 publications

(72 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5). DH activates a G-coupled receptor, BmDHR, and induces a decrease of glycogen levels with a compensating enhancement of sorbitol and glycerol [98,99]. A physiological concentration of sorbitol (0.2 M) induces diapause in non-diapausing embryos [99].…”

Section: Embryonic Diapause and Diapause Hormone Signallingmentioning

confidence: 99%

The hormonal and circadian basis for insect photoperiodic timing

2011

View full text Add to dashboard Cite

Edited by Martha Merrow and Michael BrunnerKeywords: Insects Photoperiodism Diapause Endocrine axis Circadian clock Clock genes a b s t r a c t Daylength perception in temperate zones is a critical feature of insect life histories, and leads to developmental changes for resisting unfavourable seasons. The role of the neuroendocrine axis in the photoperiodic response of insects is discussed in relation to the key organs and molecules that are involved. We also discuss the controversial issue of the possible involvement of the circadian clock in photoperiodicity. Drosophila melanogaster has a shallow photoperiodic response that leads to reproductive arrest in adults, yet the unrivalled molecular genetic toolkit available for this model insect should allow the systematic molecular and neurobiological dissection of this complex phenotype.

show abstract

Section: Embryonic Diapause and Diapause Hormone Signallingmentioning

confidence: 99%

The hormonal and circadian basis for insect photoperiodic timing

2011

View full text Add to dashboard Cite

show abstract

“…If eggs are incubated at 20°C under continuous illumination or darkness, the resultant moths produce diapause or non-diapause eggs, respectively (Kogure 1933;Morita et al 2003). The diapause hormone (DH) is a 24-amino-acid (aa) peptide amide that is responsible for embryonic diapause and functions by acting on a Gprotein-coupled receptor in the developing ovaries during pupal-adult development in females (Yamashita 1996;Homma et al 2006). DH-PBAN is a neuropeptide gene that encodes a polypeptide precursor consisting in five FXPRL amide (FXPRLa) neuropeptides; DH, PBAN (pheromone-biosynthesis-activating neuropeptide) and α-, β-and γ-SGNPs (subesophageal ganglion neuropeptides) in various insects including B. mori ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Immunoreactive intensity of FXPRL amide neuropeptides in response to environmental conditions in the silkworm, Bombyx mori

et al. 2010

Self Cite

View full text Add to dashboard Cite

In the silkworm Bombyx mori, the diapause hormone-pheromone biosynthesis activating neuropeptide gene, DH-PBAN, is a neuropeptide gene that encodes a polypeptide precursor consisting in five Phe-X-Pro-Arg-Leu-NH(2) (FXPRL) amide (FXPRLa) neuropeptides; DH (diapause hormone), PBAN (pheromone-biosynthesis-activating neuropeptide) and α-, β- and γ-SGNPs (subesophageal ganglion neuropeptides). These neuropeptides are synthesized in DH-PBAN-producing neurosecretory cells contained within three neuromeres, four mandibular cells, six maxillary cells, two labial cells (SLb) and four lateral cells of the subesophageal ganglion. DH is solely responsible, among the FXPRLa peptide family, for embryonic diapause. Functional differentiation has been previously suggested to occur at each neuromere, with the SLb cells releasing DH through brain innervation in order to induce embryonic diapause. We have investigated the immunoreactive intensity of DH in the SLb when thermal (25°C or 15°C) and light (continuous illumination or darkness) conditions are altered and following brain surgery that induces diapause or non-diapause eggs in the progeny. We have also examined the immunoreactivity of the other FXPRLa peptides by using anti-β-SGNP and anti-PBAN antibodies. Pupal SLb somata immunoreactivities seem to be affected by both thermal and light conditions during embryogenesis. Thus, we have been able to identify a close correlation between the immunoreactive intensity of neuropeptides and environmental conditions relating to the determination of embryonic diapause in B. mori.

show abstract

“…DH acts on a G protein-coupled receptor in the developing ovaries of females during pupal-adult development (12,13), and is produced in DH-pheromone-biosynthesis-activating neuropeptide-producing neurosecretory cells (DHPCs) located within the subesophageal ganglion (SG) (14)(15)(16). DH levels in the SG and SG-brain complex are markedly lower in 25DD pupae than in 15DD pupae, although level of mRNA expression is higher in 25DD than in the 15DD pupae at the early to middle stages of pupal-adult development (11,17).…”

mentioning

confidence: 99%

Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm,Bombyx mori

Sato

Sokabe

Kashio

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

In the bivoltine strain of the silkworm, Bombyx mori, embryonic diapause is induced transgenerationally as a maternal effect. Progeny diapause is determined by the environmental temperature during embryonic development of the mother; however, its molecular mechanisms are largely unknown. Here, we show that the Bombyx TRPA1 ortholog (BmTrpA1) acts as a thermosensitive transient receptor potential (TRP) channel that is activated at temperatures above ∼21°C and affects the induction of diapause in progeny. In addition, we show that embryonic RNAi of BmTrpA1 affects diapause hormone release during pupal-adult development. This study identifying a thermosensitive TRP channel that acts as a molecular switch for a relatively long-term predictive adaptive response by inducing an alternative phenotype to seasonal polyphenism is unique.

show abstract

G protein-coupled receptor for diapause hormone, an inducer of Bombyx embryonic diapause

Cited by 127 publications

References 33 publications

The hormonal and circadian basis for insect photoperiodic timing

The hormonal and circadian basis for insect photoperiodic timing

Immunoreactive intensity of FXPRL amide neuropeptides in response to environmental conditions in the silkworm, Bombyx mori

Embryonic thermosensitive TRPA1 determines transgenerational diapause phenotype of the silkworm,Bombyx mori

Contact Info

Product

Resources

About